Search Results

Overview

Uniprot IDP14314
Protein NameGlucosidase 2 subunit beta
Gene NamePRKCSH
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
142 REGFRLKKILIEDWK
149 KILIEDWKKAREEKQ
158 AREEKQKKLIELQAG
166 LIELQAGKKSLEDQV
167 IELQAGKKSLEDQVE
196 EAKEQHQKLWEEQLA
376 AAQEARNKFEEAERS
436 PFKLVSQKPKLGGSP
464 HDKFSAMKYEQGTGC
487 TVRLLCGKETMVTST

Function

Regulatory subunit of glucosidase II that cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins (PubMed:10929008). Required for efficient PKD1/Polycystin-1 biogenesis and trafficking to the plasma membrane of the primary cilia (By similarity)

Protein Sequence

10 MLLPLLLLLP 20 MCWAVEVKRP 30 RGVSLTNHHF 40 YDESKPFTCL 50 DGSATIPFDQ 60 VNDDYCDCKD 70 GSDEPGTAAC 80 PNGSFHCTNT 90 GYKPLYIPSN 100 RVNDGVCDCC 110 DGTDEYNSGV 120 ICENTCKEKG 130 RKERESLQQM 140 AEVTREGFRL 150 KKILIEDWKK 160 AREEKQKKLI 170 ELQAGKKSLE 180 DQVEMLRTVK 190 EEAEKPEREA 200 KEQHQKLWEE 210 QLAAAKAQQE 220 QELAADAFKE 230 LDDDMDGTVS 240 VTELQTHPEL 250 DTDGDGALSE 260 AEAQALLSGD 270 TQTDATSFYD 280 RVWAAIRDKY 290 RSEALPTDLP 300 APSAPDLTEP 310 KEEQPPVPSS 320 PTEEEEEEEE 330 EEEEEAEEEE 340 EEEDSEEAPP 350 PLSPPQPASP 360 AEEDKMPPYD 370 EQTQAFIDAA 380 QEARNKFEEA 390 ERSLKDMEES 400 IRNLEQEISF 410 DFGPNGEFAY 420 LYSQCYELTT 430 NEYVYRLCPF 440 KLVSQKPKLG 450 GSPTSLGTWG 460 SWIGPDHDKF 470 SAMKYEQGTG 480 CWQGPNRSTT 490 VRLLCGKETM 500 VTSTTEPSRC 510 EYLMELMTPA 520 ACPEPPPEAP TEDDHDEL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005783 endoplasmic reticulum
Cellular Component GO:0005788 endoplasmic reticulum lumen
Cellular Component GO:0017177 glucosidase II complex
Cellular Component GO:0043231 intracellular membrane-bounded organelle
Molecular Function GO:0005509 calcium ion binding
Molecular Function GO:0051219 phosphoprotein binding
Molecular Function GO:0005080 protein kinase C binding
Molecular Function GO:0044325 transmembrane transporter binding
Biological Process GO:0035556 intracellular signal transduction
Biological Process GO:0001889 liver development
Biological Process GO:0006491 N-glycan processing

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.