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Overview

Uniprot IDP14316
Protein NameInterferon regulatory factor 2
Gene NameIRF2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
337 TRASVIKKTSDITQA

Function

DNA-binding transcription factor that specifically binds to the upstream regulatory region of type I interferon (IFN) and IFN-inducible genes and regulates their expression (PubMed:39013473, PubMed:7687740). Mainly acts as a transcription repressor, repressing expression (PubMed:39013473). Also acts as an activator for several genes including H4 and IL7 (PubMed:15226432, PubMed:9540062). Constitutively binds to the ISRE promoter to activate IL7 (PubMed:15226432). Involved in cell cycle regulation through binding the site II (HiNF-M) promoter region of H4 and activating transcription during cell growth (PubMed:9540062). Antagonizes IRF1 transcriptional activation (By similarity)

Protein Sequence

10 MPVERMRMRP 20 WLEEQINSNT 30 IPGLKWLNKE 40 KKIFQIPWMH 50 AARHGWDVEK 60 DAPLFRNWAI 70 HTGKHQPGVD 80 KPDPKTWKAN 90 FRCAMNSLPD 100 IEEVKDKSIK 110 KGNNAFRVYR 120 MLPLSERPSK 130 KGKKPKTEKE 140 DKVKHIKQEP 150 VESSLGLSNG 160 VSDLSPEYAV 170 LTSTIKNEVD 180 STVNIIVVGQ 190 SHLDSNIENQ 200 EIVTNPPDIC 210 QVVEVTTESD 220 EQPVSMSELY 230 PLQISPVSSY 240 AESETTDSVP 250 SDEESAEGRP 260 HWRKRNIEGK 270 QYLSNMGTRG 280 SYLLPGMASF 290 VTSNKPDLQV 300 TIKEESNPVP 310 YNSSWPPFQD 320 LPLSSSMTPA 330 SSSSRPDRET 340 RASVIKKTSD ITQARVKSC

Gene Ontology

Classification GO ID Description
Cellular Component GO:0030054 cell junction
Cellular Component GO:0000785 chromatin
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0003677 DNA binding
Molecular Function GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
Molecular Function GO:0003700 DNA-binding transcription factor activity
Molecular Function GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
Molecular Function GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
Molecular Function GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
Molecular Function GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
Molecular Function GO:0043565 sequence-specific DNA binding
Molecular Function GO:1990837 sequence-specific double-stranded DNA binding
Biological Process GO:0008283 cell population proliferation
Biological Process GO:0051607 defense response to virus
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0002376 immune system process
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0032480 negative regulation of type I interferon production
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0006355 regulation of DNA-templated transcription
Biological Process GO:0006357 regulation of transcription by RNA polymerase II
Biological Process GO:0034138 toll-like receptor 3 signaling pathway

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.