Search Results

Overview

Uniprot IDP14317
Protein NameHematopoietic lineage cell-specific protein
Gene NameHCLS1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
118 SSQTDAAKGFGGKYG
123 AAKGFGGKYGVERDR
133 VERDRADKSAVGFDY
141 SAVGFDYKGEVEKHT
165 GGRYGVEKDKWDKAA
170 VEKDKWDKAALGYDY
178 AALGYDYKGETEKHE
192 ESQRDYAKGFGGQYG
202 GGQYGIQKDRVDKSA
207 IQKDRVDKSAVGFNE
223 EAPTTAYKKTTPIEA
224 APTTAYKKTTPIEAA
241 GTRGLKAKFESMAEE
257 RKREEEEKAQQVARR
296 AVPAPLPKKISSEAW
297 VPAPLPKKISSEAWP
41 KEQRWGAKTIEGSGR
60 NIHQLRNKVSEEHDV
78 KEMESGPKASHGYGG
96 VERDRMDKSAVGHEY

Function

Substrate of the antigen receptor-coupled tyrosine kinase. Plays a role in antigen receptor signaling for both clonal expansion and deletion in lymphoid cells. May also be involved in the regulation of gene expression

Protein Sequence

10 MWKSVVGHDV 20 SVSVETQGDD 30 WDTDPDFVND 40 ISEKEQRWGA 50 KTIEGSGRTE 60 HINIHQLRNK 70 VSEEHDVLRK 80 KEMESGPKAS 90 HGYGGRFGVE 100 RDRMDKSAVG 110 HEYVAEVEKH 120 SSQTDAAKGF 130 GGKYGVERDR 140 ADKSAVGFDY 150 KGEVEKHTSQ 160 KDYSRGFGGR 170 YGVEKDKWDK 180 AALGYDYKGE 190 TEKHESQRDY 200 AKGFGGQYGI 210 QKDRVDKSAV 220 GFNEMEAPTT 230 AYKKTTPIEA 240 ASSGTRGLKA 250 KFESMAEEKR 260 KREEEEKAQQ 270 VARRQQERKA 280 VTKRSPEAPQ 290 PVIAMEEPAV 300 PAPLPKKISS 310 EAWPPVGTPP 320 SSESEPVRTS 330 REHPVPLLPI 340 RQTLPEDNEE 350 PPALPPRTLE 360 GLQVEEEPVY 370 EAEPEPEPEP 380 EPEPENDYED 390 VEEMDRHEQE 400 DEPEGDYEEV 410 LEPEDSSFSS 420 ALAGSSGCPA 430 GAGAGAVALG 440 ISAVAVYDYQ 450 GEGSDELSFD 460 PDDVITDIEM 470 VDEGWWRGRC 480 HGHFGLFPAN YVKLLE

Gene Ontology

Classification GO ID Description
Biological Process GO:0007165 signal transduction
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0030139 endocytic vesicle
Cellular Component GO:0005739 mitochondrion
Cellular Component GO:0005634 nucleus
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0005667 transcription regulator complex
Molecular Function GO:0051015 actin filament binding
Molecular Function GO:0019901 protein kinase binding
Molecular Function GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding
Molecular Function GO:0017124 SH3 domain binding
Molecular Function GO:0035591 signaling adaptor activity
Biological Process GO:0007015 actin filament organization
Biological Process GO:0071345 cellular response to cytokine stimulus
Biological Process GO:0030218 erythrocyte differentiation
Biological Process GO:0038158 granulocyte colony-stimulating factor signaling pathway
Biological Process GO:0035556 intracellular signal transduction
Biological Process GO:2000107 negative regulation of leukocyte apoptotic process
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0051169 nuclear transport
Biological Process GO:0008284 positive regulation of cell population proliferation
Biological Process GO:0030854 positive regulation of granulocyte differentiation
Biological Process GO:0045651 positive regulation of macrophage differentiation
Biological Process GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
Biological Process GO:0042307 positive regulation of protein import into nucleus
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0030833 regulation of actin filament polymerization
Biological Process GO:0006355 regulation of DNA-templated transcription
Biological Process GO:0009725 response to hormone

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.

[4] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[5] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.