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Overview

Uniprot IDP14324
Protein NameFarnesyl pyrophosphate synthase
Gene NameFDPS
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
112 GDAIARLKEVLEYNA
123 EYNAIGGKYNRGLTV
142 RELVEPRKQDADSLQ
295 EKEHANAKKILLEMG
332 GTDIQDNKCSWLVVQ
353 PEQYQILKENYGQKE
359 LKENYGQKEAEKVAR

Function

Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate

Protein Sequence

10 MPLSRWLRSV 20 GVFLLPAPYW 30 APRERWLGSL 40 RRPSLVHGYP 50 VLAWHSARCW 60 CQAWTEEPRA 70 LCSSLRMNGD 80 QNSDVYAQEK 90 QDFVQHFSQI 100 VRVLTEDEMG 110 HPEIGDAIAR 120 LKEVLEYNAI 130 GGKYNRGLTV 140 VVAFRELVEP 150 RKQDADSLQR 160 AWTVGWCVEL 170 LQAFFLVADD 180 IMDSSLTRRG 190 QICWYQKPGV 200 GLDAINDANL 210 LEACIYRLLK 220 LYCREQPYYL 230 NLIELFLQSS 240 YQTEIGQTLD 250 LLTAPQGNVD 260 LVRFTEKRYK 270 SIVKYKTAFY 280 SFYLPIAAAM 290 YMAGIDGEKE 300 HANAKKILLE 310 MGEFFQIQDD 320 YLDLFGDPSV 330 TGKIGTDIQD 340 NKCSWLVVQC 350 LQRATPEQYQ 360 ILKENYGQKE 370 AEKVARVKAL 380 YEELDLPAVF 390 LQYEEDSYSH 400 IMALIEQYAA 410 PLPPAVFLGL ARKIYKRRK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Biological Process GO:0036197 zymosterol biosynthetic process
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005759 mitochondrial matrix
Cellular Component GO:0005777 peroxisome
Molecular Function GO:0004337 (2E,6E)-farnesyl diphosphate synthase activity
Molecular Function GO:0004161 dimethylallyltranstransferase activity
Molecular Function GO:0046872 metal ion binding
Molecular Function GO:0003723 RNA binding
Biological Process GO:0006695 cholesterol biosynthetic process
Biological Process GO:0033489 cholesterol biosynthetic process via desmosterol
Biological Process GO:0033490 cholesterol biosynthetic process via lathosterol
Biological Process GO:0045337 farnesyl diphosphate biosynthetic process
Biological Process GO:0010142 farnesyl diphosphate biosynthetic process, mevalonate pathway
Biological Process GO:0033384 geranyl diphosphate biosynthetic process
Biological Process GO:0033386 geranylgeranyl diphosphate biosynthetic process

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[4] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[5] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.