Overview
| Uniprot ID | P14406 |
|---|
| Protein Name | Cytochrome c oxidase subunit 7A2, mitochondrial |
|---|
| Gene Name | COX7A2 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 33 |
NKVPEKQKLFQEDDE |
Function
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Protein Sequence
10
MLRNLLALRQ
20
IGQRTISTAS
30
RRHFKNKVPE
40
KQKLFQEDDE
50
IPLYLKGGVA
60
DALLYRATMI
70
LTVGGTAYAI
80
YELAVASFPK
KQE
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005743 |
mitochondrial inner membrane |
| Cellular Component |
GO:0031966 |
mitochondrial membrane |
| Cellular Component |
GO:0005739 |
mitochondrion |
| Cellular Component |
GO:0098803 |
respiratory chain complex |
| Cellular Component |
GO:0045277 |
respiratory chain complex IV |
| Molecular Function |
GO:0016491 |
oxidoreductase activity |
| Molecular Function |
GO:0030674 |
protein-macromolecule adaptor activity |
| Biological Process |
GO:0045333 |
cellular respiration |
| Biological Process |
GO:0006123 |
mitochondrial electron transport, cytochrome c to oxygen |
| Biological Process |
GO:0006119 |
oxidative phosphorylation |
Reference
[1] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.