Search Results
Overview
| Uniprot ID | P14408 |
|---|---|
| Protein Name | Fumarate hydratase, mitochondrial |
| Gene Name | Fh |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 169 | LGGELGSKKPVHPND |
| 170 | GGELGSKKPVHPNDH |
| 218 | LHDALSAKSKEFAQV |
| 220 | DALSAKSKEFAQVIK |
| 444 | ANTERINKLMNESLM |
| 58 | YDTFGELKVPTDKYY |
| 63 | ELKVPTDKYYGAQTV |
| 77 | VRSTMNFKIGGATER |
Function
Catalyzes the reversible stereospecific interconversion of fumarate to L-malate (By similarity). Experiments in other species have demonstrated that specific isoforms of this protein act in defined pathways and favor one direction over the other (Probable)
Protein Sequence
10
MNRAFCLLAR
20
SRRFPRVPSA
30
GAVLSGEAAT
40
LPRCAPNVVR
50
MASQNSFRIE
60
YDTFGELKVP
70
TDKYYGAQTV
80
RSTMNFKIGG
90
ATERMPIPVI
100
KAFGILKRAA
110
AEVNQEYGLD
120
PKIASAIMKA
130
ADEVAEGKLN
140
DHFPLVVWQT
150
GSGTQTNMNV
160
NEVISNRAIE
170
MLGGELGSKK
180
PVHPNDHVNK
190
SQSSNDTFPT
200
AMHIAAALEV
210
HQVLLPGLQK
220
LHDALSAKSK
230
EFAQVIKIGR
240
THTQDAVPLT
250
LGQEFSGYVQ
260
QVQYAMERIK
270
AAMPRIYELA
280
AGGTAVGTGL
290
NTRIGFAEKV
300
AAKVAALTGL
310
PFVTAPNKFE
320
ALAAHDALVE
330
LSGAMNTTAC
340
SLMKIANDIR
350
FLGSGPRSGL
360
GELILPENEP
370
GSSIMPGKVN
380
PTQCEAMTMV
390
AAQVMGNHVA
400
VTVGGSNGHF
410
ELNVFKPMMI
420
KNVLHSARLL
430
GDASVSFTEN
440
CVVGIQANTE
450
RINKLMNESL
460
MLVTALNPHI
470
GYDKAAKIAK
480
TAHKNGSTLK
490
ETAIELGYLT
500
AEQFDEWVKP
KDMLGPK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0035861 | site of double-strand break |
| Molecular Function | GO:0004333 | fumarate hydratase activity |
| Molecular Function | GO:0042393 | histone binding |
| Biological Process | GO:0006525 | arginine metabolic process |
| Biological Process | GO:0006974 | DNA damage response |
| Biological Process | GO:0006281 | DNA repair |
| Biological Process | GO:0006106 | fumarate metabolic process |
| Biological Process | GO:0006108 | malate metabolic process |
| Biological Process | GO:0120162 | positive regulation of cold-induced thermogenesis |
| Biological Process | GO:2001034 | positive regulation of double-strand break repair via nonhomologous end joining |
| Biological Process | GO:0006099 | tricarboxylic acid cycle |
| Biological Process | GO:0000050 | urea cycle |
Reference
[1] Yao Y, Bade R, Li G, Zhang A, Zhao H et al.. Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats.. Cell Mol Neurobiol 43(5):1989-2004. 2023 Jul. PMID: 36030297.
[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.