Search Results
Overview
| Uniprot ID | P14602 |
|---|---|
| Protein Name | Heat shock protein beta-1 |
| Gene Name | Hspb1 |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 118 | EELTVKTKEGVVEIT |
| 127 | GVVEITGKHEERQDE |
| 202 | IGGPEAGKSEQSGAK |
Function
Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding-competent state. Plays a role in stress resistance and actin organization (PubMed:17661394). Through its molecular chaperone activity may regulate numerous biological processes including the phosphorylation and the axonal transport of neurofilament proteins (By similarity)
Protein Sequence
10
MTERRVPFSL
20
LRSPSWEPFR
30
DWYPAHSRLF
40
DQAFGVPRLP
50
DEWSQWFSAA
60
GWPGYVRPLP
70
AATAEGPAAV
80
TLAAPAFSRA
90
LNRQLSSGVS
100
EIRQTADRWR
110
VSLDVNHFAP
120
EELTVKTKEG
130
VVEITGKHEE
140
RQDEHGYISR
150
CFTRKYTLPP
160
GVDPTLVSSS
170
LSPEGTLTVE
180
APLPKAVTQS
190
AEITIPVTFE
200
ARAQIGGPEA
GKSEQSGAK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0030424 | axon |
| Biological Process | GO:0043536 | positive regulation of blood vessel endothelial cell migration |
| Biological Process | GO:2001028 | positive regulation of endothelial cell chemotaxis |
| Biological Process | GO:0032731 | positive regulation of interleukin-1 beta production |
| Biological Process | GO:0010976 | positive regulation of neuron projection development |
| Biological Process | GO:0032760 | positive regulation of tumor necrosis factor production |
| Biological Process | GO:0006457 | protein folding |
| Biological Process | GO:0042026 | protein refolding |
| Biological Process | GO:0043122 | regulation of canonical NF-kappaB signal transduction |
| Biological Process | GO:0001932 | regulation of protein phosphorylation |
| Biological Process | GO:0009408 | response to heat |
| Biological Process | GO:0006986 | response to unfolded protein |
| Biological Process | GO:0009615 | response to virus |
| Biological Process | GO:0048010 | vascular endothelial growth factor receptor signaling pathway |
| Cellular Component | GO:1904115 | axon cytoplasm |
| Cellular Component | GO:0097512 | cardiac myofibril |
| Cellular Component | GO:0043292 | contractile muscle fiber |
| Cellular Component | GO:0001533 | cornified envelope |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0030425 | dendrite |
| Cellular Component | GO:0031674 | I band |
| Cellular Component | GO:0031430 | M band |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0043204 | perikaryon |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0098839 | postsynaptic density membrane |
| Cellular Component | GO:0000502 | proteasome complex |
| Cellular Component | GO:0005819 | spindle |
| Cellular Component | GO:0030018 | Z disc |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0044183 | protein folding chaperone |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Molecular Function | GO:0019901 | protein kinase binding |
| Molecular Function | GO:0005080 | protein kinase C binding |
| Molecular Function | GO:0008426 | protein kinase C inhibitor activity |
| Molecular Function | GO:0061629 | RNA polymerase II-specific DNA-binding transcription factor binding |
| Molecular Function | GO:0043130 | ubiquitin binding |
| Molecular Function | GO:0051082 | unfolded protein binding |
| Biological Process | GO:0099641 | anterograde axonal protein transport |
| Biological Process | GO:0035924 | cellular response to vascular endothelial growth factor stimulus |
| Biological Process | GO:0060729 | intestinal epithelial structure maintenance |
| Biological Process | GO:0035556 | intracellular signal transduction |
| Biological Process | GO:0043066 | negative regulation of apoptotic process |
| Biological Process | GO:2001234 | negative regulation of apoptotic signaling pathway |
| Biological Process | GO:1900408 | negative regulation of cellular response to oxidative stress |
| Biological Process | GO:1902176 | negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway |
| Biological Process | GO:0090038 | negative regulation of protein kinase C signaling |
| Biological Process | GO:0045590 | negative regulation of regulatory T cell differentiation |
| Biological Process | GO:0045766 | positive regulation of angiogenesis |
Reference
[1] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.