Search Results
Overview
| Uniprot ID | P14635 |
|---|---|
| Protein Name | G2/mitotic-specific cyclin-B1 |
| Gene Name | CCNB1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 10 | LRVTRNSKINAENKA |
| 16 | SKINAENKAKINMAG |
Function
Essential for the control of the cell cycle at the G2/M (mitosis) transition (PubMed:27030811, PubMed:17495531, PubMed:17495533). Binds and activates cyclin-dependent protein kinase CDK1/CDC2 (PubMed:41100585)
Protein Sequence
10
MALRVTRNSK
20
INAENKAKIN
30
MAGAKRVPTA
40
PAATSKPGLR
50
PRTALGDIGN
60
KVSEQLQAKM
70
PMKKEAKPSA
80
TGKVIDKKLP
90
KPLEKVPMLV
100
PVPVSEPVPE
110
PEPEPEPEPV
120
KEEKLSPEPI
130
LVDTASPSPM
140
ETSGCAPAEE
150
DLCQAFSDVI
160
LAVNDVDAED
170
GADPNLCSEY
180
VKDIYAYLRQ
190
LEEEQAVRPK
200
YLLGREVTGN
210
MRAILIDWLV
220
QVQMKFRLLQ
230
ETMYMTVSII
240
DRFMQNNCVP
250
KKMLQLVGVT
260
AMFIASKYEE
270
MYPPEIGDFA
280
FVTDNTYTKH
290
QIRQMEMKIL
300
RALNFGLGRP
310
LPLHFLRRAS
320
KIGEVDVEQH
330
TLAKYLMELT
340
MLDYDMVHFP
350
PSQIAAGAFC
360
LALKILDNGE
370
WTPTLQHYLS
380
YTEESLLPVM
390
QHLAKNVVMV
400
NQGLTKHMTV
410
KNKYATSKHA
420
KISTLPQLNS
430
ALVQDLAKAV
AKV
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Biological Process | GO:0000086 | G2/M transition of mitotic cell cycle |
| Cellular Component | GO:0005813 | centrosome |
| Cellular Component | GO:0097125 | cyclin B1-CDK1 complex |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0005815 | microtubule organizing center |
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0000940 | outer kinetochore |
| Cellular Component | GO:0000922 | spindle pole |
| Molecular Function | GO:0061575 | cyclin-dependent protein serine/threonine kinase activator activity |
| Molecular Function | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity |
| Molecular Function | GO:0005113 | patched binding |
| Molecular Function | GO:0019901 | protein kinase binding |
| Molecular Function | GO:0044389 | ubiquitin-like protein ligase binding |
| Biological Process | GO:0051301 | cell division |
| Biological Process | GO:0071398 | cellular response to fatty acid |
| Biological Process | GO:0071456 | cellular response to hypoxia |
| Biological Process | GO:0071283 | cellular response to iron(III) ion |
| Biological Process | GO:0048565 | digestive tract development |
| Biological Process | GO:0000082 | G1/S transition of mitotic cell cycle |
| Biological Process | GO:0007080 | mitotic metaphase chromosome alignment |
| Biological Process | GO:0007052 | mitotic spindle organization |
| Biological Process | GO:0010629 | negative regulation of gene expression |
| Biological Process | GO:0001556 | oocyte maturation |
| Biological Process | GO:0051987 | positive regulation of attachment of spindle microtubules to kinetochore |
| Biological Process | GO:0060045 | positive regulation of cardiac muscle cell proliferation |
| Biological Process | GO:0010971 | positive regulation of G2/M transition of mitotic cell cycle |
| Biological Process | GO:1905448 | positive regulation of mitochondrial ATP synthesis coupled electron transport |
| Biological Process | GO:0045931 | positive regulation of mitotic cell cycle |
| Biological Process | GO:0031442 | positive regulation of mRNA 3'-end processing |
| Biological Process | GO:0065003 | protein-containing complex assembly |
| Biological Process | GO:0060623 | regulation of chromosome condensation |
| Biological Process | GO:0090266 | regulation of mitotic cell cycle spindle assembly checkpoint |
| Biological Process | GO:0046680 | response to DDT |
| Biological Process | GO:0009612 | response to mechanical stimulus |
| Biological Process | GO:0009410 | response to xenobiotic stimulus |
| Biological Process | GO:0007283 | spermatogenesis |
| Biological Process | GO:0042246 | tissue regeneration |
| Biological Process | GO:0055015 | ventricular cardiac muscle cell development |
Reference
[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.