Search Results
Overview
| Uniprot ID | P14678 |
|---|---|
| Protein Name | Small nuclear ribonucleoprotein-associated proteins B and B' |
| Gene Name | SNRPB |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 8 | MTVGKSSKMLQHIDY |
| 88 | TVEGPPPKDTGIARV |
Function
Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (PubMed:11991638, PubMed:18984161, PubMed:19325628, PubMed:25555158, PubMed:26912367, PubMed:28076346, PubMed:28502770, PubMed:28781166, PubMed:32494006). Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes (PubMed:11991638, PubMed:28076346, PubMed:28502770, PubMed:28781166). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (PubMed:15146077). As part of the U7 snRNP it is involved in histone pre-mRNA 3'-end processing (PubMed:12975319)
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0071013 | catalytic step 2 spliceosome |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0071204 | histone pre-mRNA 3'end processing complex |
| Cellular Component | GO:0034709 | methylosome |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0030532 | small nuclear ribonucleoprotein complex |
| Cellular Component | GO:0034719 | SMN-Sm protein complex |
| Cellular Component | GO:0005681 | spliceosomal complex |
| Cellular Component | GO:0005697 | telomerase holoenzyme complex |
| Cellular Component | GO:0005685 | U1 snRNP |
| Cellular Component | GO:0005689 | U12-type spliceosomal complex |
| Cellular Component | GO:0005686 | U2 snRNP |
| Cellular Component | GO:0071007 | U2-type catalytic step 2 spliceosome |
| Cellular Component | GO:0071005 | U2-type precatalytic spliceosome |
| Cellular Component | GO:0071004 | U2-type prespliceosome |
| Cellular Component | GO:0005684 | U2-type spliceosomal complex |
| Cellular Component | GO:0005687 | U4 snRNP |
| Cellular Component | GO:0046540 | U4/U6 x U5 tri-snRNP complex |
| Cellular Component | GO:0005682 | U5 snRNP |
| Cellular Component | GO:0005683 | U7 snRNP |
| Molecular Function | GO:0071208 | histone pre-mRNA DCP binding |
| Molecular Function | GO:0003723 | RNA binding |
| Molecular Function | GO:0070990 | snRNP binding |
| Molecular Function | GO:0070034 | telomerase RNA binding |
| Molecular Function | GO:1990446 | U1 snRNP binding |
| Molecular Function | GO:1990447 | U2 snRNP binding |
| Biological Process | GO:0036261 | 7-methylguanosine cap hypermethylation |
| Biological Process | GO:0000398 | mRNA splicing, via spliceosome |
| Biological Process | GO:0048025 | negative regulation of mRNA splicing, via spliceosome |
| Biological Process | GO:0071045 | nuclear histone mRNA catabolic process |
| Biological Process | GO:0006479 | protein methylation |
| Biological Process | GO:0008380 | RNA splicing |
| Biological Process | GO:0000245 | spliceosomal complex assembly |
| Biological Process | GO:0000387 | spliceosomal snRNP assembly |
| Biological Process | GO:0000244 | spliceosomal tri-snRNP complex assembly |
| Biological Process | GO:0000388 | spliceosome conformational change to release U4 (or U4atac) and U1 (or U11) |
| Biological Process | GO:1903241 | U2-type prespliceosome assembly |
Reference
[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.
[2] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.