Search Results
Overview
| Uniprot ID | P14824 |
|---|---|
| Protein Name | Annexin A6 |
| Gene Name | Anxa6 |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 102 | YCDAKEIKDAISGVG |
| 3 | *****MAKIAQGAMY |
| 370 | FNPDADAKALRKAMK |
| 377 | KALRKAMKGIGTDEA |
| 613 | DKLYKSMKGAGTDEK |
| 99 | PLAYCDAKEIKDAIS |
Function
May associate with CD21. May regulate the release of Ca(2+) from intracellular stores
Protein Sequence
10
MAKIAQGAMY
20
RGSVHDFPEF
30
DANQDAEALY
40
TAMKGFGSDK
50
ESILELITSR
60
SNKQRQEICQ
70
NYKSLYGKDL
80
IEDLKYELTG
90
KFERLIVNLM
100
RPLAYCDAKE
110
IKDAISGVGT
120
DEKCLIEILA
130
SRTNEQMHQL
140
VAAYKDAYER
150
DLESDIIGDT
160
SGHFQKMLVV
170
LLQGTRENDD
180
VVSEDLVQQD
190
VQDLYEAGEL
200
KWGTDEAQFI
210
YILGNRSKQH
220
LRLVFDEYLK
230
TTGKPIEASI
240
RGELSGDFEK
250
LMLAVVKCIR
260
STPEYFAERL
270
FKAMKGLGTR
280
DNTLIRIMVS
290
RSELDMLDIR
300
EIFRTKYEKS
310
LYSMIKNDTS
320
GEYKKALLKL
330
CGGDDDAAGQ
340
FFPEAAQVAY
350
QMWELSAVSR
360
VELKGTVCAA
370
NDFNPDADAK
380
ALRKAMKGIG
390
TDEATIIDIV
400
THRSNAQRQQ
410
IRQTFKSHFG
420
RDLMADLKSE
430
ISGDLARLIL
440
GLMMPPAHYD
450
AKQLKKAMEG
460
AGTDEKTLIE
470
ILATRTNAEI
480
RAINEAYKED
490
YHKSLEDALS
500
SDTSGHFRRI
510
LISLATGNRE
520
EGGENRDQAQ
530
EDAQVAAEIL
540
EIADTPSGDK
550
TSLETRFMTV
560
LCTRSYPHLR
570
RVFQEFIKKT
580
NYDIEHVIKK
590
EMSGDVKDAF
600
VAIVQSVKNK
610
PLFFADKLYK
620
SMKGAGTDEK
630
TLTRVMVSRS
640
EIDLLNIRRE
650
FIEKYDKSLH
660
QAIEGDTSGD
670
FMKALLALCG
GED
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0016324 | apical plasma membrane |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0031012 | extracellular matrix |
| Cellular Component | GO:0014704 | intercalated disc |
| Cellular Component | GO:0031902 | late endosome membrane |
| Cellular Component | GO:0005765 | lysosomal membrane |
| Cellular Component | GO:0042470 | melanosome |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0032991 | protein-containing complex |
| Cellular Component | GO:0042383 | sarcolemma |
| Cellular Component | GO:0012506 | vesicle membrane |
| Molecular Function | GO:0005509 | calcium ion binding |
| Molecular Function | GO:0005544 | calcium-dependent phospholipid binding |
| Molecular Function | GO:0048306 | calcium-dependent protein binding |
| Molecular Function | GO:0015485 | cholesterol binding |
| Molecular Function | GO:0005525 | GTP binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0015276 | ligand-gated monoatomic ion channel activity |
| Molecular Function | GO:0008289 | lipid binding |
| Molecular Function | GO:0001786 | phosphatidylserine binding |
| Molecular Function | GO:0044877 | protein-containing complex binding |
| Biological Process | GO:0097190 | apoptotic signaling pathway |
| Biological Process | GO:0006816 | calcium ion transport |
| Biological Process | GO:0051560 | mitochondrial calcium ion homeostasis |
| Biological Process | GO:0034220 | monoatomic ion transmembrane transport |
| Biological Process | GO:0051283 | negative regulation of sequestering of calcium ion |
| Biological Process | GO:0006937 | regulation of muscle contraction |
Reference
[1] Chang J, Wu W, Qian P, Lu Z, He X et al.. Multi-omics study on the effect of moderate-intensity exercise on protein lactylation in mouse muscle tissue.. Front Cell Dev Biol 12:1472338. 2024. PMID: 39935788.
[2] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.