Search Results
Overview
| Uniprot ID | P14859 |
|---|---|
| Protein Name | POU domain, class 2, transcription factor 1 |
| Gene Name | POU2F1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 272 | PQSQSTPKRIDTPSL |
Function
Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR
Protein Sequence
10
MNNPSETSKP
20
SMESGDGNTG
30
TQTNGLDFQK
40
QPVPVGGAIS
50
TAQAQAFLGH
60
LHQVQLAGTS
70
LQAAAQSLNV
80
QSKSNEESGD
90
SQQPSQPSQQ
100
PSVQAAIPQT
110
QLMLAGGQIT
120
GLTLTPAQQQ
130
LLLQQAQAQA
140
QLLAAAVQQH
150
SASQQHSAAG
160
ATISASAATP
170
MTQIPLSQPI
180
QIAQDLQQLQ
190
QLQQQNLNLQ
200
QFVLVHPTTN
210
LQPAQFIISQ
220
TPQGQQGLLQ
230
AQNLLTQLPQ
240
QSQANLLQSQ
250
PSITLTSQPA
260
TPTRTIAATP
270
IQTLPQSQST
280
PKRIDTPSLE
290
EPSDLEELEQ
300
FAKTFKQRRI
310
KLGFTQGDVG
320
LAMGKLYGND
330
FSQTTISRFE
340
ALNLSFKNMC
350
KLKPLLEKWL
360
NDAENLSSDS
370
SLSSPSALNS
380
PGIEGLSRRR
390
KKRTSIETNI
400
RVALEKSFLE
410
NQKPTSEEIT
420
MIADQLNMEK
430
EVIRVWFCNR
440
RQKEKRINPP
450
SSGGTSSSPI
460
KAIFPSPTSL
470
VATTPSLVTS
480
SAATTLTVSP
490
VLPLTSAAVT
500
NLSVTGTSDT
510
TSNNTATVIS
520
TAPPASSAVT
530
SPSLSPSPSA
540
SASTSEASSA
550
SETSTTQTTS
560
TPLSSPLGTS
570
QVMVTASGLQ
580
TAAAAALQGA
590
AQLPANASLA
600
AMAAAAGLNP
610
SLMAPSQFAA
620
GGALLSLNPG
630
TLSGALSPAL
640
MSNSTLATIQ
650
ALASGGSLPI
660
TSLDATGNLV
670
FANAGGAPNI
680
VTAPLFLNPQ
690
NLSLLTSNPV
700
SLVSAAAASA
710
GNSAPVASLH
720
ATSTSAESIQ
730
NSLFTVASAS
740
GAASTTTTAS
KAQ
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0000785 | chromatin |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0090575 | RNA polymerase II transcription regulator complex |
| Molecular Function | GO:0003677 | DNA binding |
| Molecular Function | GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific |
| Molecular Function | GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| Molecular Function | GO:0000979 | RNA polymerase II core promoter sequence-specific DNA binding |
| Molecular Function | GO:0043565 | sequence-specific DNA binding |
| Biological Process | GO:0006351 | DNA-templated transcription |
| Biological Process | GO:0045892 | negative regulation of DNA-templated transcription |
| Biological Process | GO:1902895 | positive regulation of miRNA transcription |
| Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| Biological Process | GO:0006357 | regulation of transcription by RNA polymerase II |
Reference
PMID: N/A