Search Results
Overview
| Uniprot ID | P14868 |
|---|---|
| Protein Name | Aspartate--tRNA ligase, cytoplasmic |
| Gene Name | DARS1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 453 | GIDLEKIKAYIDSFR |
| 9 | PSASASRKSQEKPRE |
Function
Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA
Protein Sequence
10
MPSASASRKS
20
QEKPREIMDA
30
AEDYAKERYG
40
ISSMIQSQEK
50
PDRVLVRVRD
60
LTIQKADEVV
70
WVRARVHTSR
80
AKGKQCFLVL
90
RQQQFNVQAL
100
VAVGDHASKQ
110
MVKFAANINK
120
ESIVDVEGVV
130
RKVNQKIGSC
140
TQQDVELHVQ
150
KIYVISLAEP
160
RLPLQLDDAV
170
RPEAEGEEEG
180
RATVNQDTRL
190
DNRVIDLRTS
200
TSQAVFRLQS
210
GICHLFRETL
220
INKGFVEIQT
230
PKIISAASEG
240
GANVFTVSYF
250
KNNAYLAQSP
260
QLYKQMCICA
270
DFEKVFSIGP
280
VFRAEDSNTH
290
RHLTEFVGLD
300
IEMAFNYHYH
310
EVMEEIADTM
320
VQIFKGLQER
330
FQTEIQTVNK
340
QFPCEPFKFL
350
EPTLRLEYCE
360
ALAMLREAGV
370
EMGDEDDLST
380
PNEKLLGHLV
390
KEKYDTDFYI
400
LDKYPLAVRP
410
FYTMPDPRNP
420
KQSNSYDMFM
430
RGEEILSGAQ
440
RIHDPQLLTE
450
RALHHGIDLE
460
KIKAYIDSFR
470
FGAPPHAGGG
480
IGLERVTMLF
490
LGLHNVRQTS
500
MFPRDPKRLT
P
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0017101 | aminoacyl-tRNA synthetase multienzyme complex |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0045202 | synapse |
| Molecular Function | GO:0004046 | aminoacylase activity |
| Molecular Function | GO:0004815 | aspartate-tRNA ligase activity |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0003723 | RNA binding |
| Biological Process | GO:0006422 | aspartyl-tRNA aminoacylation |
| Biological Process | GO:0065003 | protein-containing complex assembly |
| Biological Process | GO:0006412 | translation |
| Biological Process | GO:0006418 | tRNA aminoacylation for protein translation |
Reference
[1] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.
[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.