Search Results

Overview

Uniprot IDP15144
Protein NameAminopeptidase N
Gene NameANPEP
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
125 DVIIIHSKKLNYTLS
205 YMEGNVRKVVATTQM
379 LSSSSSNKERVVTVI
641 YDEENWRKIQTQLQR
836 RAALACSKELWILNR
943 ALEQALEKTKANIKW

Function

Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis and promote cholesterol crystallization. May have a role in amino acid transport by acting as binding partner of amino acid transporter SLC6A19 and regulating its activity (By similarity)

Protein Sequence

10 MAKGFYISKS 20 LGILGILLGV 30 AAVCTIIALS 40 VVYSQEKNKN 50 ANSSPVASTT 60 PSASATTNPA 70 SATTLDQSKA 80 WNRYRLPNTL 90 KPDSYRVTLR 100 PYLTPNDRGL 110 YVFKGSSTVR 120 FTCKEATDVI 130 IIHSKKLNYT 140 LSQGHRVVLR 150 GVGGSQPPDI 160 DKTELVEPTE 170 YLVVHLKGSL 180 VKDSQYEMDS 190 EFEGELADDL 200 AGFYRSEYME 210 GNVRKVVATT 220 QMQAADARKS 230 FPCFDEPAMK 240 AEFNITLIHP 250 KDLTALSNML 260 PKGPSTPLPE 270 DPNWNVTEFH 280 TTPKMSTYLL 290 AFIVSEFDYV 300 EKQASNGVLI 310 RIWARPSAIA 320 AGHGDYALNV 330 TGPILNFFAG 340 HYDTPYPLPK 350 SDQIGLPDFN 360 AGAMENWGLV 370 TYRENSLLFD 380 PLSSSSSNKE 390 RVVTVIAHEL 400 AHQWFGNLVT 410 IEWWNDLWLN 420 EGFASYVEYL 430 GADYAEPTWN 440 LKDLMVLNDV 450 YRVMAVDALA 460 SSHPLSTPAS 470 EINTPAQISE 480 LFDAISYSKG 490 ASVLRMLSSF 500 LSEDVFKQGL 510 ASYLHTFAYQ 520 NTIYLNLWDH 530 LQEAVNNRSI 540 QLPTTVRDIM 550 NRWTLQMGFP 560 VITVDTSTGT 570 LSQEHFLLDP 580 DSNVTRPSEF 590 NYVWIVPITS 600 IRDGRQQQDY 610 WLIDVRAQND 620 LFSTSGNEWV 630 LLNLNVTGYY 640 RVNYDEENWR 650 KIQTQLQRDH 660 SAIPVINRAQ 670 IINDAFNLAS 680 AHKVPVTLAL 690 NNTLFLIEER 700 QYMPWEAALS 710 SLSYFKLMFD 720 RSEVYGPMKN 730 YLKKQVTPLF 740 IHFRNNTNNW 750 REIPENLMDQ 760 YSEVNAISTA 770 CSNGVPECEE 780 MVSGLFKQWM 790 ENPNNNPIHP 800 NLRSTVYCNA 810 IAQGGEEEWD 820 FAWEQFRNAT 830 LVNEADKLRA 840 ALACSKELWI 850 LNRYLSYTLN 860 PDLIRKQDAT 870 STIISITNNV 880 IGQGLVWDFV 890 QSNWKKLFND 900 YGGGSFSFSN 910 LIQAVTRRFS 920 TEYELQQLEQ 930 FKKDNEETGF 940 GSGTRALEQA 950 LEKTKANIKW 960 VKENKEVVLQ WFTENSK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005793 endoplasmic reticulum-Golgi intermediate compartment
Molecular Function GO:0001618 virus receptor activity
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0001525 angiogenesis
Biological Process GO:0002003 angiotensin maturation
Biological Process GO:0030154 cell differentiation
Biological Process GO:0043171 peptide catabolic process
Cellular Component GO:0009897 external side of plasma membrane
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0005615 extracellular space
Cellular Component GO:0005765 lysosomal membrane
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0030667 secretory granule membrane
Molecular Function GO:0016285 alanyl aminopeptidase activity
Molecular Function GO:0004177 aminopeptidase activity
Molecular Function GO:0070006 metalloaminopeptidase activity
Molecular Function GO:0008237 metallopeptidase activity
Molecular Function GO:0038023 signaling receptor activity

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.