Search Results
Overview
| Uniprot ID | P15153 |
|---|---|
| Protein Name | Ras-related C3 botulinum toxin substrate 2 |
| Gene Name | RAC2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 133 | IEKLKEKKLAPITYP |
| 166 | ALTQRGLKTVFDEAI |
Function
Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state (PubMed:30723080). In its active state, binds to a variety of effector proteins to regulate cellular responses, such as secretory processes, phagocytose of apoptotic cells and epithelial cell polarization. Regulatory subunit of the phagocyte NADPH oxidase complex that mediates the transfer of electrons from cytosolic NADPH to O2 to produce the superoxide anion (O2(-)) (PubMed:1660188). Activates PLCG2 (PubMed:19394299)
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0042995 | cell projection |
| Cellular Component | GO:0031410 | cytoplasmic vesicle |
| Cellular Component | GO:0005856 | cytoskeleton |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005789 | endoplasmic reticulum membrane |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0005925 | focal adhesion |
| Cellular Component | GO:0030027 | lamellipodium |
| Cellular Component | GO:0005741 | mitochondrial outer membrane |
| Cellular Component | GO:0043020 | NADPH oxidase complex |
| Cellular Component | GO:0005635 | nuclear envelope |
| Cellular Component | GO:0030670 | phagocytic vesicle membrane |
| Cellular Component | GO:0005886 | plasma membrane |
| Molecular Function | GO:0003925 | G protein activity |
| Molecular Function | GO:0005525 | GTP binding |
| Molecular Function | GO:0003924 | GTPase activity |
| Molecular Function | GO:0019901 | protein kinase binding |
| Molecular Function | GO:0019887 | protein kinase regulator activity |
| Biological Process | GO:0007015 | actin filament organization |
| Biological Process | GO:0045453 | bone resorption |
| Biological Process | GO:0006935 | chemotaxis |
| Biological Process | GO:0030865 | cortical cytoskeleton organization |
| Biological Process | GO:0007163 | establishment or maintenance of cell polarity |
| Biological Process | GO:0071593 | lymphocyte aggregation |
| Biological Process | GO:0010592 | positive regulation of lamellipodium assembly |
| Biological Process | GO:0090023 | positive regulation of neutrophil chemotaxis |
| Biological Process | GO:1903955 | positive regulation of protein targeting to mitochondrion |
| Biological Process | GO:0032956 | regulation of actin cytoskeleton organization |
| Biological Process | GO:0008360 | regulation of cell shape |
| Biological Process | GO:0010810 | regulation of cell-substrate adhesion |
| Biological Process | GO:0010310 | regulation of hydrogen peroxide metabolic process |
| Biological Process | GO:0060753 | regulation of mast cell chemotaxis |
| Biological Process | GO:0043304 | regulation of mast cell degranulation |
| Biological Process | GO:1902622 | regulation of neutrophil migration |
| Biological Process | GO:0060263 | regulation of respiratory burst |
| Biological Process | GO:0042129 | regulation of T cell proliferation |
| Biological Process | GO:0045730 | respiratory burst |
| Biological Process | GO:0007165 | signal transduction |
| Biological Process | GO:0007264 | small GTPase-mediated signal transduction |
| Biological Process | GO:0042554 | superoxide anion generation |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.
[3] Chao L, Xu Y, Yang Y, Ao X, Liang J. Identification of lactylation-related biomarkers for diagnosis, prognosis, and treatment responsiveness in triple-negative breast cancer.. World J Surg Oncol 24(1):77. 2026 Jan 22. PMID: 41566505.