Search Results

Overview

Uniprot IDP15205
Protein NameMicrotubule-associated protein 1B
Gene NameMap1b
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
1511 GSFKEDTKMSISEGT
1770 VQSLEGEKLSPKSDI
1774 EGEKLSPKSDISPLT
1851 LTTSSVEKDNGGKTP
1924 ETIEKTTKTPEDGGY
1969 VSGYTYEKTERSRRL
2043 ETMEKITKTPQASTY
2271 SPKPGALKESSDKVS
2276 ALKESSDKVSRVASP
2291 KKKESVEKAMKTTTT
2294 ESVEKAMKTTTTPEV
2302 TTTTPEVKATRGEEK
2323 AANASASKSVKTATA
2326 ASASKSVKTATAGPG
2371 NVDVEFFKRVRSSYY
327 INSMLQRKIAELEEE
506 LEGLEKLKHLDFLKQ
531 QVSTPPVKQVKLKQR
555 ATKPLSSKSVRKESK
562 KSVRKESKEEAPEAT
570 EEAPEATKASQVEKT
595 VKKDKPGKVESKPSV
610 TEKEVPSKEEQSPVK
617 KEEQSPVKAEVAEKA
623 VKAEVAEKAATESKP
643 KVVKKEIKTKPEEKK
739 KISKDIKKSTPLSDT
748 TPLSDTKKPAALKPK
753 TKKPAALKPKVAKKE
755 KPAALKPKVAKKEEP
772 KEPIAAGKLKDKGKV
98 SPEVPGQKILHHRSD
980 AEADVHIKEKRESVA

Function

Required for proper microtubule dynamics. Plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (By similarity). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing (By similarity). Facilitates tyrosination of alpha-tubulin in neuronal microtubules. Required for synaptic maturation (By similarity)

Protein Sequence

10 MATVVVEATE 20 PEPSGSIGNP 30 AATTSPSLSH 40 RFLDSKFYLL 50 VVVGETVTEE 60 HLRRAIGNIE 70 LGIRSWDTNL 80 IECNLDQELK 90 LFVSRHSARF 100 SPEVPGQKIL 110 HHRSDVLETV 120 VLINPSDEAV 130 STEVRLMITD 140 AARHKLLVLT 150 GQCFENTGEL 160 ILQSGSFSFQ 170 NFIEIFTDQE 180 IGELLSTTHP 190 ANKASLTLFC 200 PEEGDWKNSN 210 LDRHNLQDFI 220 NIKLNSASIL 230 PEMEGLSEFT 240 EYLSESVEVP 250 SPFDILEPPT 260 SGGFLKLSKP 270 CCYIFPGGRG 280 DSALFAVNGF 290 NMLINGGSER 300 KSCFWKLIRH 310 LDRVDSILLT 320 HIGDDNLPGI 330 NSMLQRKIAE 340 LEEERSQGST 350 SNSDWMKNLI 360 SPDLGVVFLN 370 VPENLKNPEP 380 NIKMKRSTEE 390 ACFTLQYLNK 400 LSMKPEPLFR 410 SVGNAIEPVI 420 LFQKMGVGKL 430 EMYVLNPVKS 440 SKEMQYFMQQ 450 WTGTNKDKAE 460 LILPNGQEVD 470 IPISYLTSVS 480 SLIVWHPANP 490 AEKIIRVLFP 500 GNSTQYNILE 510 GLEKLKHLDF 520 LKQPLATQKD 530 LTGQVSTPPV 540 KQVKLKQRAD 550 SRESLKPATK 560 PLSSKSVRKE 570 SKEEAPEATK 580 ASQVEKTPKV 590 ESKEKVIVKK 600 DKPGKVESKP 610 SVTEKEVPSK 620 EEQSPVKAEV 630 AEKAATESKP 640 KVTKDKVVKK 650 EIKTKPEEKK 660 EEKPKKEVAK 670 KEDKTPLKKD 680 EKPKKEEAKK 690 EIKKEIKKEE 700 KKELKKEVKK 710 ETPLKDAKKE 720 VKKDEKKEVK 730 KEEKEPKKEI 740 KKISKDIKKS 750 TPLSDTKKPA 760 ALKPKVAKKE 770 EPTKKEPIAA 780 GKLKDKGKVK 790 VIKKEGKTTE 800 AAATAVGTAA 810 VAAAAGVAAS 820 GPAKELEAER 830 SLMSSPEDLT 840 KDFEELKAEE 850 IDVAKDIKPQ 860 LELIEDEEKL 870 KETEPGEAYV 880 IQKETEVSKG 890 SAESPDEGIT 900 TTEGEGECEQ 910 TPEELEPVEK 920 QGVDDIEKFE 930 DEGAGFEESS 940 EAGDYEEKAE 950 TEEAEEPEED 960 GEDNVSGSAS 970 KHSPTEDEEI 980 AKAEADVHIK 990 EKRESVASGD 1000 DRAEEDMDEA 1010 LEKGEAEQSE 1020 EEGEEEEDKA 1030 EDAREEDHEP 1040 DKTEAEDYVM 1050 AVVDKAAEAG 1060 VTEDQYGFLG 1070 TPAKQPGVQS 1080 PSREPASSIH 1090 DETLPGGSES 1100 EATASDEENR 1110 EDQPEEFTAT 1120 SGYTQSTIEI 1130 SSEPTPMDEM 1140 STPRDVMSDE 1150 TNNEETESPS 1160 QEFVNITKYE 1170 SSLYSQEYSK 1180 PVVASFNGLS 1190 DGSKTDATDG 1200 RDYNASASTI 1210 SPPSSMEEDK 1220 FSKSALRDAY 1230 RPEETDVKTG 1240 AELDIKDVSD 1250 ERLSPAKSPS 1260 LSPSPPSPIE 1270 KTPLGERSVN 1280 FSLTPNEIKA 1290 SAEGEATAVV 1300 SPGVTQAVVE 1310 EHCASPEEKT 1320 LEVVSPSQSV 1330 TGSAGHTPYY 1340 QSPTDEKSSH 1350 LPTEVTEKPQ 1360 AVPVSFEFTE 1370 AKDENERSSI 1380 SPMDEPVPDS 1390 ESPIEKVLSP 1400 LRSPPLIGSE 1410 SAYEDFLSAD 1420 DKALGRRSES 1430 PFEGKNGKQG 1440 FSDKESPVSD 1450 LTSDLYQDKQ 1460 EEKSAGFIPI 1470 KEDFSPEKKA 1480 SDAEIMSSQS 1490 ALALDERKLG 1500 GDGSPTQVDV 1510 SQFGSFKEDT 1520 KMSISEGTVS 1530 DKSATPVDEG 1540 VAEDTYSHME 1550 GVASVSTASV 1560 ATSSFPEPTT 1570 DDVSPSLHAE 1580 VGSPHSTEVD 1590 DSLSVSVVQT 1600 PTTFQETEMS 1610 PSKEECPRPM 1620 SISPPDFSPK 1630 TAKSRTPVQD 1640 HRSEQSSMSI 1650 EFGQESPEHS 1660 LAMDFSRQSP 1670 DHPTVGAGML 1680 HITENGPTEV 1690 DYSPSDIQDS 1700 SLSHKIPPTE 1710 EPSYTQDNDL 1720 SELISVSQVE 1730 ASPSTSSAHT 1740 PSQIASPLQE 1750 DTLSDVVPPR 1760 DMSLYASLAS 1770 EKVQSLEGEK 1780 LSPKSDISPL 1790 TPRESSPTYS 1800 PGFSDSTSGA 1810 KESTAAYQTS 1820 SSPPIDAAAA 1830 EPYGFRSSML 1840 FDTMQHHLAL 1850 SRDLTTSSVE 1860 KDNGGKTPGD 1870 FNYAYQKPES 1880 TTESPDEEDY 1890 DYESHEKTIQ 1900 AHDVGGYYYE 1910 KTERTIKSPC 1920 DSGYSYETIE 1930 KTTKTPEDGG 1940 YSCEITEKTT 1950 RTPEEGGYSY 1960 EISEKTTRTP 1970 EVSGYTYEKT 1980 ERSRRLLDDI 1990 SNGYDDTEDG 2000 GHTLGDCSYS 2010 YETTEKITSF 2020 PESESYSYET 2030 TTKTTRSPDT 2040 SAYCYETMEK 2050 ITKTPQASTY 2060 SYETSDRCYT 2070 PERKSPSEAR 2080 QDVDLCLVSS 2090 CEFKHPKTEL 2100 SPSFINPNPL 2110 EWFAGEEPTE 2120 ESEKPLTQSG 2130 GAPPPSGGKQ 2140 QGRQCDETPP 2150 TSVSESAPSQ 2160 TDSDVPPETE 2170 ECPSITADAN 2180 IDSEDESETI 2190 PTDKTVTYKH 2200 MDPPPAPMQD 2210 RSPSPRHPDV 2220 SMVDPEALAI 2230 EQNLGKALKK 2240 DLKEKAKTKK 2250 PGTKTKSSSP 2260 VKKGDGKSKP 2270 SAASPKPGAL 2280 KESSDKVSRV 2290 ASPKKKESVE 2300 KAMKTTTTPE 2310 VKATRGEEKD 2320 KETKNAANAS 2330 ASKSVKTATA 2340 GPGTTKTAKS 2350 STVPPGLPVY 2360 LDLCYIPNHS 2370 NSKNVDVEFF 2380 KRVRSSYYVV 2390 SGNDPAAEEP 2400 SRAVLDALLE 2410 GKAQWGSNMQ 2420 VTLIPTHDSE 2430 VMREWYQETH 2440 EKQQDLNIMV 2450 LASSSTVVMQ 2460 DESFPACKIE L

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005875 microtubule associated complex
Cellular Component GO:0097440 apical dendrite
Cellular Component GO:0030424 axon
Cellular Component GO:0097441 basal dendrite
Cellular Component GO:0005829 cytosol
Cellular Component GO:0030425 dendrite
Cellular Component GO:0043197 dendritic spine
Cellular Component GO:0098978 glutamatergic synapse
Cellular Component GO:0030426 growth cone
Cellular Component GO:0097457 hippocampal mossy fiber
Cellular Component GO:0005874 microtubule
Cellular Component GO:0043025 neuronal cell body
Cellular Component GO:0043204 perikaryon
Cellular Component GO:0048471 perinuclear region of cytoplasm
Cellular Component GO:0001750 photoreceptor outer segment
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0098794 postsynapse
Cellular Component GO:0014069 postsynaptic density
Cellular Component GO:0036477 somatodendritic compartment
Cellular Component GO:0045202 synapse
Cellular Component GO:0043196 varicosity
Molecular Function GO:0003779 actin binding
Molecular Function GO:0008017 microtubule binding
Molecular Function GO:0005543 phospholipid binding
Molecular Function GO:0044877 protein-containing complex binding
Biological Process GO:0048675 axon extension
Biological Process GO:0007409 axonogenesis
Biological Process GO:0071363 cellular response to growth factor stimulus
Biological Process GO:0071375 cellular response to peptide hormone stimulus
Biological Process GO:0016358 dendrite development
Biological Process GO:0021700 developmental maturation
Biological Process GO:0061162 establishment of monopolar cell polarity
Biological Process GO:0051915 induction of synaptic plasticity by chemical substance
Biological Process GO:0001578 microtubule bundle formation
Biological Process GO:0000226 microtubule cytoskeleton organization
Biological Process GO:0047497 mitochondrion transport along microtubule
Biological Process GO:0032387 negative regulation of intracellular transport
Biological Process GO:0007026 negative regulation of microtubule depolymerization
Biological Process GO:0007399 nervous system development
Biological Process GO:0048666 neuron development
Biological Process GO:0031175 neuron projection development
Biological Process GO:0071895 odontoblast differentiation
Biological Process GO:0014012 peripheral nervous system axon regeneration
Biological Process GO:0045773 positive regulation of axon extension
Biological Process GO:0031116 positive regulation of microtubule polymerization
Biological Process GO:0045666 positive regulation of neuron differentiation
Biological Process GO:0031114 regulation of microtubule depolymerization
Biological Process GO:0150052 regulation of postsynapse assembly
Biological Process GO:0048678 response to axon injury
Biological Process GO:0009743 response to carbohydrate
Biological Process GO:0032355 response to estradiol
Biological Process GO:0017085 response to insecticide
Biological Process GO:0009612 response to mechanical stimulus
Biological Process GO:0031667 response to nutrient levels
Biological Process GO:0033189 response to vitamin A
Biological Process GO:0009410 response to xenobiotic stimulus
Biological Process GO:0007416 synapse assembly

Reference

[1] Yao Y, Bade R, Li G, Zhang A, Zhao H et al.. Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats.. Cell Mol Neurobiol 43(5):1989-2004. 2023 Jul. PMID: 36030297.

[2] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.

[3] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.