Search Results
Overview
| Uniprot ID | P15205 |
|---|---|
| Protein Name | Microtubule-associated protein 1B |
| Gene Name | Map1b |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 1511 | GSFKEDTKMSISEGT |
| 1770 | VQSLEGEKLSPKSDI |
| 1774 | EGEKLSPKSDISPLT |
| 1851 | LTTSSVEKDNGGKTP |
| 1924 | ETIEKTTKTPEDGGY |
| 1969 | VSGYTYEKTERSRRL |
| 2043 | ETMEKITKTPQASTY |
| 2271 | SPKPGALKESSDKVS |
| 2276 | ALKESSDKVSRVASP |
| 2291 | KKKESVEKAMKTTTT |
| 2294 | ESVEKAMKTTTTPEV |
| 2302 | TTTTPEVKATRGEEK |
| 2323 | AANASASKSVKTATA |
| 2326 | ASASKSVKTATAGPG |
| 2371 | NVDVEFFKRVRSSYY |
| 327 | INSMLQRKIAELEEE |
| 506 | LEGLEKLKHLDFLKQ |
| 531 | QVSTPPVKQVKLKQR |
| 555 | ATKPLSSKSVRKESK |
| 562 | KSVRKESKEEAPEAT |
| 570 | EEAPEATKASQVEKT |
| 595 | VKKDKPGKVESKPSV |
| 610 | TEKEVPSKEEQSPVK |
| 617 | KEEQSPVKAEVAEKA |
| 623 | VKAEVAEKAATESKP |
| 643 | KVVKKEIKTKPEEKK |
| 739 | KISKDIKKSTPLSDT |
| 748 | TPLSDTKKPAALKPK |
| 753 | TKKPAALKPKVAKKE |
| 755 | KPAALKPKVAKKEEP |
| 772 | KEPIAAGKLKDKGKV |
| 98 | SPEVPGQKILHHRSD |
| 980 | AEADVHIKEKRESVA |
Function
Required for proper microtubule dynamics. Plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (By similarity). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing (By similarity). Facilitates tyrosination of alpha-tubulin in neuronal microtubules. Required for synaptic maturation (By similarity)
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005875 | microtubule associated complex |
| Cellular Component | GO:0097440 | apical dendrite |
| Cellular Component | GO:0030424 | axon |
| Cellular Component | GO:0097441 | basal dendrite |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0030425 | dendrite |
| Cellular Component | GO:0043197 | dendritic spine |
| Cellular Component | GO:0098978 | glutamatergic synapse |
| Cellular Component | GO:0030426 | growth cone |
| Cellular Component | GO:0097457 | hippocampal mossy fiber |
| Cellular Component | GO:0005874 | microtubule |
| Cellular Component | GO:0043025 | neuronal cell body |
| Cellular Component | GO:0043204 | perikaryon |
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| Cellular Component | GO:0001750 | photoreceptor outer segment |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0098794 | postsynapse |
| Cellular Component | GO:0014069 | postsynaptic density |
| Cellular Component | GO:0036477 | somatodendritic compartment |
| Cellular Component | GO:0045202 | synapse |
| Cellular Component | GO:0043196 | varicosity |
| Molecular Function | GO:0003779 | actin binding |
| Molecular Function | GO:0008017 | microtubule binding |
| Molecular Function | GO:0005543 | phospholipid binding |
| Molecular Function | GO:0044877 | protein-containing complex binding |
| Biological Process | GO:0048675 | axon extension |
| Biological Process | GO:0007409 | axonogenesis |
| Biological Process | GO:0071363 | cellular response to growth factor stimulus |
| Biological Process | GO:0071375 | cellular response to peptide hormone stimulus |
| Biological Process | GO:0016358 | dendrite development |
| Biological Process | GO:0021700 | developmental maturation |
| Biological Process | GO:0061162 | establishment of monopolar cell polarity |
| Biological Process | GO:0051915 | induction of synaptic plasticity by chemical substance |
| Biological Process | GO:0001578 | microtubule bundle formation |
| Biological Process | GO:0000226 | microtubule cytoskeleton organization |
| Biological Process | GO:0047497 | mitochondrion transport along microtubule |
| Biological Process | GO:0032387 | negative regulation of intracellular transport |
| Biological Process | GO:0007026 | negative regulation of microtubule depolymerization |
| Biological Process | GO:0007399 | nervous system development |
| Biological Process | GO:0048666 | neuron development |
| Biological Process | GO:0031175 | neuron projection development |
| Biological Process | GO:0071895 | odontoblast differentiation |
| Biological Process | GO:0014012 | peripheral nervous system axon regeneration |
| Biological Process | GO:0045773 | positive regulation of axon extension |
| Biological Process | GO:0031116 | positive regulation of microtubule polymerization |
| Biological Process | GO:0045666 | positive regulation of neuron differentiation |
| Biological Process | GO:0031114 | regulation of microtubule depolymerization |
| Biological Process | GO:0150052 | regulation of postsynapse assembly |
| Biological Process | GO:0048678 | response to axon injury |
| Biological Process | GO:0009743 | response to carbohydrate |
| Biological Process | GO:0032355 | response to estradiol |
| Biological Process | GO:0017085 | response to insecticide |
| Biological Process | GO:0009612 | response to mechanical stimulus |
| Biological Process | GO:0031667 | response to nutrient levels |
| Biological Process | GO:0033189 | response to vitamin A |
| Biological Process | GO:0009410 | response to xenobiotic stimulus |
| Biological Process | GO:0007416 | synapse assembly |
Reference
[1] Yao Y, Bade R, Li G, Zhang A, Zhao H et al.. Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats.. Cell Mol Neurobiol 43(5):1989-2004. 2023 Jul. PMID: 36030297.
[2] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.
[3] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.