Search Results

Overview

Uniprot IDP15259
Protein NamePhosphoglycerate mutase 2
Gene NamePGAM2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
100 GGLTGLNKAETAAKH
106 NKAETAAKHGEEQVK
138 PYYNSISKERRYAGL
146 ERRYAGLKPGELPTC
251 EAVAAQGKAK*****
253 VAAQGKAK*******

Function

Catalyzes the interconversion of 3- and 2-phosphoglycerate with 2,3-bisphosphoglycerate as the primer of the reaction. Can also catalyze the interconversion of (2R)-2,3-bisphosphoglycerate and (2R)-3-phospho-glyceroyl phosphate, but with a reduced activity

Protein Sequence

10 MATHRLVMVR 20 HGESTWNQEN 30 RFCGWFDAEL 40 SEKGTEEAKR 50 GAKAIKDAKM 60 EFDICYTSVL 70 KRAIRTLWAI 80 LDGTDQMWLP 90 VVRTWRLNER 100 HYGGLTGLNK 110 AETAAKHGEE 120 QVKIWRRSFD 130 IPPPPMDEKH 140 PYYNSISKER 150 RYAGLKPGEL 160 PTCESLKDTI 170 ARALPFWNEE 180 IVPQIKAGKR 190 VLIAAHGNSL 200 RGIVKHLEGM 210 SDQAIMELNL 220 PTGIPIVYEL 230 NKELKPTKPM 240 QFLGDEETVR 250 KAMEAVAAQG KAK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:1990917 ooplasm
Molecular Function GO:0004082 bisphosphoglycerate mutase activity
Molecular Function GO:0016787 hydrolase activity
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0004619 phosphoglycerate mutase activity
Biological Process GO:0061621 canonical glycolysis
Biological Process GO:0006094 gluconeogenesis
Biological Process GO:0006096 glycolytic process
Biological Process GO:0046689 response to mercury ion
Biological Process GO:0007283 spermatogenesis
Biological Process GO:0006941 striated muscle contraction

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] Yan M, Tu H, Tang S, Gai Z, Shi Q et al.. Lactylated Proteomic Analysis Reveals Functional Implications of Lysine Lactylation In Asthenozoospermia.. Mol Cell Proteomics 24(12):101439. 2025 Dec. PMID: 41192556.