Search Results
Overview
| Uniprot ID | P15311 |
|---|---|
| Protein Name | Ezrin |
| Gene Name | EZR |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 139 | AKFGDYNKEVHKSGY |
| 143 | DYNKEVHKSGYLSSE |
| 162 | QRVMDQHKLTRDQWE |
| 263 | VIKPIDKKAPDFVFY |
| 3 | *****MPKPINVRVT |
| 344 | KEQMMREKEELMLRL |
| 357 | RLQDYEEKTKKAERE |
| 438 | LEEARRRKEDEVEEW |
| 450 | EEWQHRAKEAQDDLV |
| 64 | TWLKLDKKVSAQEVR |
| 72 | VSAQEVRKENPLQFK |
| 79 | KENPLQFKFRAKFYP |
| 83 | LQFKFRAKFYPEDVA |
Function
Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis
Protein Sequence
10
MPKPINVRVT
20
TMDAELEFAI
30
QPNTTGKQLF
40
DQVVKTIGLR
50
EVWYFGLHYV
60
DNKGFPTWLK
70
LDKKVSAQEV
80
RKENPLQFKF
90
RAKFYPEDVA
100
EELIQDITQK
110
LFFLQVKEGI
120
LSDEIYCPPE
130
TAVLLGSYAV
140
QAKFGDYNKE
150
VHKSGYLSSE
160
RLIPQRVMDQ
170
HKLTRDQWED
180
RIQVWHAEHR
190
GMLKDNAMLE
200
YLKIAQDLEM
210
YGINYFEIKN
220
KKGTDLWLGV
230
DALGLNIYEK
240
DDKLTPKIGF
250
PWSEIRNISF
260
NDKKFVIKPI
270
DKKAPDFVFY
280
APRLRINKRI
290
LQLCMGNHEL
300
YMRRRKPDTI
310
EVQQMKAQAR
320
EEKHQKQLER
330
QQLETEKKRR
340
ETVEREKEQM
350
MREKEELMLR
360
LQDYEEKTKK
370
AERELSEQIQ
380
RALQLEEERK
390
RAQEEAERLE
400
ADRMAALRAK
410
EELERQAVDQ
420
IKSQEQLAAE
430
LAEYTAKIAL
440
LEEARRRKED
450
EVEEWQHRAK
460
EAQDDLVKTK
470
EELHLVMTAP
480
PPPPPPVYEP
490
VSYHVQESLQ
500
DEGAEPTGYS
510
AELSSEGIRD
520
DRNEEKRITE
530
AEKNERVQRQ
540
LLTLSSELSQ
550
ARDENKRTHN
560
DIIHNENMRQ
570
GRDKYKTLRQ
580
IRQGNTKQRI
DEFEAL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Biological Process | GO:0008360 | regulation of cell shape |
| Cellular Component | GO:0015629 | actin cytoskeleton |
| Cellular Component | GO:0005884 | actin filament |
| Cellular Component | GO:0005912 | adherens junction |
| Cellular Component | GO:0045177 | apical part of cell |
| Cellular Component | GO:0016324 | apical plasma membrane |
| Cellular Component | GO:0016323 | basolateral plasma membrane |
| Cellular Component | GO:0005903 | brush border |
| Cellular Component | GO:0071944 | cell periphery |
| Cellular Component | GO:0042995 | cell projection |
| Cellular Component | GO:0036064 | ciliary basal body |
| Cellular Component | GO:0030863 | cortical cytoskeleton |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005768 | endosome |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:0030175 | filopodium |
| Cellular Component | GO:0005925 | focal adhesion |
| Cellular Component | GO:0001772 | immunological synapse |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0005902 | microvillus |
| Cellular Component | GO:0031528 | microvillus membrane |
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0044853 | plasma membrane raft |
| Cellular Component | GO:0032991 | protein-containing complex |
| Cellular Component | GO:0001726 | ruffle |
| Cellular Component | GO:0032587 | ruffle membrane |
| Cellular Component | GO:0001931 | uropod |
| Cellular Component | GO:0031982 | vesicle |
| Molecular Function | GO:0003779 | actin binding |
| Molecular Function | GO:0051015 | actin filament binding |
| Molecular Function | GO:0051117 | ATPase binding |
| Molecular Function | GO:0045296 | cadherin binding |
| Molecular Function | GO:0050839 | cell adhesion molecule binding |
| Molecular Function | GO:0097718 | disordered domain specific binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0008017 | microtubule binding |
| Molecular Function | GO:0019904 | protein domain specific binding |
| Molecular Function | GO:0051018 | protein kinase A binding |
| Molecular Function | GO:0034236 | protein kinase A catalytic subunit binding |
| Molecular Function | GO:0034237 | protein kinase A regulatory subunit binding |
| Molecular Function | GO:0003723 | RNA binding |
| Molecular Function | GO:0044548 | S100 protein binding |
| Biological Process | GO:0030036 | actin cytoskeleton organization |
| Biological Process | GO:0051017 | actin filament bundle assembly |
| Biological Process | GO:0030953 | astral microtubule organization |
| Biological Process | GO:0141156 | cAMP/PKA signal transduction |
| Biological Process | GO:0043622 | cortical microtubule organization |
| Biological Process | GO:0051660 | establishment of centrosome localization |
| Biological Process | GO:0061028 | establishment of endothelial barrier |
| Biological Process | GO:0046847 | filopodium assembly |
| Biological Process | GO:0001951 | intestinal D-glucose absorption |
| Biological Process | GO:0007159 | leukocyte cell-cell adhesion |
| Biological Process | GO:0022614 | membrane to membrane docking |
| Biological Process | GO:0030033 | microvillus assembly |
| Biological Process | GO:0070373 | negative regulation of ERK1 and ERK2 cascade |
| Biological Process | GO:1903753 | negative regulation of p38MAPK cascade |
| Biological Process | GO:0050860 | negative regulation of T cell receptor signaling pathway |
| Biological Process | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| Biological Process | GO:2000643 | positive regulation of early endosome to late endosome transport |
| Biological Process | GO:0010628 | positive regulation of gene expression |
| Biological Process | GO:1902207 | positive regulation of interleukin-2-mediated signaling pathway |
| Biological Process | GO:0040018 | positive regulation of multicellular organism growth |
| Biological Process | GO:0045732 | positive regulation of protein catabolic process |
| Biological Process | GO:1902966 | positive regulation of protein localization to early endosome |
| Biological Process | GO:1903078 | positive regulation of protein localization to plasma membrane |
| Biological Process | GO:0098974 | postsynaptic actin cytoskeleton organization |
| Biological Process | GO:0072697 | protein localization to cell cortex |
| Biological Process | GO:0072659 | protein localization to plasma membrane |
| Biological Process | GO:0031503 | protein-containing complex localization |
| Biological Process | GO:0032532 | regulation of microvillus length |
| Biological Process | GO:1902115 | regulation of organelle assembly |
| Biological Process | GO:0003376 | sphingosine-1-phosphate receptor signaling pathway |
| Biological Process | GO:1902896 | terminal web assembly |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.
[3] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.
[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.