Overview
| Uniprot ID | P15328 |
|---|
| Protein Name | Folate receptor alpha |
|---|
| Gene Name | FOLR1 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 41 |
LNVCMNAKHHKEKPG |
Function
Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells (PubMed:19074442, PubMed:23851396, PubMed:23934049, PubMed:2527252, PubMed:8033114, PubMed:8567728). Has high affinity for folate and folic acid analogs at neutral pH (PubMed:23851396, PubMed:23934049, PubMed:2527252, PubMed:8033114, PubMed:8567728). Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release (PubMed:8567728). Required for normal embryonic development and normal cell proliferation (By similarity)
Protein Sequence
10
MAQRMTTQLL
20
LLLVWVAVVG
30
EAQTRIAWAR
40
TELLNVCMNA
50
KHHKEKPGPE
60
DKLHEQCRPW
70
RKNACCSTNT
80
SQEAHKDVSY
90
LYRFNWNHCG
100
EMAPACKRHF
110
IQDTCLYECS
120
PNLGPWIQQV
130
DQSWRKERVL
140
NVPLCKEDCE
150
QWWEDCRTSY
160
TCKSNWHKGW
170
NWTSGFNKCA
180
VGAACQPFHF
190
YFPTPTVLCN
200
EIWTHSYKVS
210
NYSRGSGRCI
220
QMWFDPAQGN
230
PNEEVARFYA
240
AAMSGAGPWA
250
AWPFLLSLAL
MLLWLLS
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0016324 |
apical plasma membrane |
| Cellular Component |
GO:0016323 |
basolateral plasma membrane |
| Cellular Component |
GO:0031526 |
brush border membrane |
| Cellular Component |
GO:0009986 |
cell surface |
| Cellular Component |
GO:0030136 |
clathrin-coated vesicle |
| Cellular Component |
GO:0005789 |
endoplasmic reticulum membrane |
| Cellular Component |
GO:0033116 |
endoplasmic reticulum-Golgi intermediate compartment membrane |
| Cellular Component |
GO:0005768 |
endosome |
| Cellular Component |
GO:0012507 |
ER to Golgi transport vesicle membrane |
| Cellular Component |
GO:0009897 |
external side of plasma membrane |
| Cellular Component |
GO:0070062 |
extracellular exosome |
| Cellular Component |
GO:0000139 |
Golgi membrane |
| Cellular Component |
GO:0016020 |
membrane |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Cellular Component |
GO:0030133 |
transport vesicle |
| Molecular Function |
GO:0005542 |
folic acid binding |
| Molecular Function |
GO:0061714 |
folic acid receptor activity |
| Molecular Function |
GO:0038023 |
signaling receptor activity |
| Biological Process |
GO:0061713 |
anterior neural tube closure |
| Biological Process |
GO:0031103 |
axon regeneration |
| Biological Process |
GO:0003253 |
cardiac neural crest cell migration involved in outflow tract morphogenesis |
| Biological Process |
GO:0007155 |
cell adhesion |
| Biological Process |
GO:0071231 |
cellular response to folic acid |
| Biological Process |
GO:0015884 |
folic acid transport |
| Biological Process |
GO:0007342 |
fusion of sperm to egg plasma membrane involved in single fertilization |
| Biological Process |
GO:0001947 |
heart looping |
| Biological Process |
GO:0003147 |
neural crest cell migration involved in heart formation |
| Biological Process |
GO:0061626 |
pharyngeal arch artery morphogenesis |
| Biological Process |
GO:0006898 |
receptor-mediated endocytosis |
| Biological Process |
GO:0060828 |
regulation of canonical Wnt signaling pathway |
| Biological Process |
GO:0017015 |
regulation of transforming growth factor beta receptor signaling pathway |
| Biological Process |
GO:0035036 |
sperm-egg recognition |
| Biological Process |
GO:0046654 |
tetrahydrofolate biosynthetic process |
Reference
[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.