Search Results
Overview
| Uniprot ID | P15337 |
|---|---|
| Protein Name | Cyclic AMP-responsive element-binding protein 1 |
| Gene Name | Creb1 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 122 | SRRPSYRKILNDLSS |
Function
Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters (By similarity). Transcription activation is enhanced by the TORC coactivators which act independently of Ser-119 phosphorylation (By similarity). Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells (By similarity). Regulates the expression of apoptotic and inflammatory response factors in cardiomyocytes in response to ERFE-mediated activation of AKT signaling (PubMed:30566056)
Protein Sequence
10
MTMDSGADNQ
20
QSGDAAVTEA
30
ESQQMTVQAQ
40
PQIATLAQVS
50
MPAAHATSSA
60
PTVTLVQLPN
70
GQTVQVHGVI
80
QAAQPSVIQS
90
PQVQTVQIST
100
IAESEDSQES
110
VDSVTDSQKR
120
REILSRRPSY
130
RKILNDLSSD
140
APGVPRIEEE
150
KSEEETSAPA
160
ITTVTVPTPI
170
YQTSSGQYIA
180
ITQGGAIQLA
190
NNGTDGVQGL
200
QTLTMTNAAA
210
TQPGTTILQY
220
AQTTDGQQIL
230
VPSNQVVVQA
240
ASGDVQTYQI
250
RTAPTSTIAP
260
GVVMASSPAL
270
PTQPAEEAAR
280
KREVRLMKNR
290
EAARECRRKK
300
KEYVKCLENR
310
VAVLENQNKT
320
LIEELKALKD
LYCHKSD
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Biological Process | GO:2000224 | regulation of testosterone biosynthetic process |
| Biological Process | GO:0006357 | regulation of transcription by RNA polymerase II |
| Biological Process | GO:0014823 | response to activity |
| Biological Process | GO:0042220 | response to cocaine |
| Biological Process | GO:1903494 | response to dehydroepiandrosterone |
| Biological Process | GO:0036017 | response to erythropoietin |
| Biological Process | GO:0045471 | response to ethanol |
| Biological Process | GO:0033762 | response to glucagon |
| Biological Process | GO:1990910 | response to hypobaric hypoxia |
| Biological Process | GO:0001666 | response to hypoxia |
| Biological Process | GO:1902065 | response to L-glutamate |
| Biological Process | GO:0043278 | response to morphine |
| Biological Process | GO:0035094 | response to nicotine |
| Biological Process | GO:0014074 | response to purine-containing compound |
| Biological Process | GO:0009410 | response to xenobiotic stimulus |
| Biological Process | GO:0033363 | secretory granule organization |
| Biological Process | GO:0006366 | transcription by RNA polymerase II |
| Biological Process | GO:0007179 | transforming growth factor beta receptor signaling pathway |
| Biological Process | GO:0060509 | type I pneumocyte differentiation |
| Biological Process | GO:0008542 | visual learning |
| Cellular Component | GO:1990589 | ATF4-CREB1 transcription factor complex |
| Cellular Component | GO:0030424 | axon |
| Cellular Component | GO:0000785 | chromatin |
| Cellular Component | GO:0000791 | euchromatin |
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0090575 | RNA polymerase II transcription regulator complex |
| Cellular Component | GO:0005667 | transcription regulator complex |
| Molecular Function | GO:1990763 | arrestin family protein binding |
| Molecular Function | GO:0035497 | cAMP response element binding |
| Molecular Function | GO:0003677 | DNA binding |
| Molecular Function | GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific |
| Molecular Function | GO:0003700 | DNA-binding transcription factor activity |
| Molecular Function | GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific |
| Molecular Function | GO:0003690 | double-stranded DNA binding |
| Molecular Function | GO:0019899 | enzyme binding |
| Molecular Function | GO:0035035 | histone acetyltransferase binding |
| Molecular Function | GO:0030544 | Hsp70 protein binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| Molecular Function | GO:0000977 | RNA polymerase II transcription regulatory region sequence-specific DNA binding |
| Molecular Function | GO:0061629 | RNA polymerase II-specific DNA-binding transcription factor binding |
| Molecular Function | GO:0043565 | sequence-specific DNA binding |
| Molecular Function | GO:1990837 | sequence-specific double-stranded DNA binding |
| Molecular Function | GO:0000976 | transcription cis-regulatory region binding |
| Molecular Function | GO:0001223 | transcription coactivator binding |
| Biological Process | GO:0007409 | axonogenesis |
| Biological Process | GO:0141156 | cAMP/PKA signal transduction |
| Biological Process | GO:0030154 | cell differentiation |
| Biological Process | GO:0071398 | cellular response to fatty acid |
| Biological Process | GO:1904322 | cellular response to forskolin |
| Biological Process | GO:0071363 | cellular response to growth factor stimulus |
| Biological Process | GO:0035729 | cellular response to hepatocyte growth factor stimulus |
| Biological Process | GO:1990314 | cellular response to insulin-like growth factor stimulus |
| Biological Process | GO:1990830 | cellular response to leukemia inhibitory factor |
| Biological Process | GO:1990090 | cellular response to nerve growth factor stimulus |
| Biological Process | GO:0036120 | cellular response to platelet-derived growth factor stimulus |
| Biological Process | GO:0071300 | cellular response to retinoic acid |
| Biological Process | GO:0071560 | cellular response to transforming growth factor beta stimulus |
| Biological Process | GO:0071294 | cellular response to zinc ion |
| Biological Process | GO:0034670 | chemotaxis to arachidonate |
| Biological Process | GO:0007623 | circadian rhythm |
| Biological Process | GO:0007595 | lactation |
| Biological Process | GO:0060428 | lung epithelium development |
| Biological Process | GO:0060430 | lung saccule development |
| Biological Process | GO:0030879 | mammary gland development |
| Biological Process | GO:0007613 | memory |
| Biological Process | GO:0042789 | mRNA transcription by RNA polymerase II |
| Biological Process | GO:0043066 | negative regulation of apoptotic process |
| Biological Process | GO:0010629 | negative regulation of gene expression |
| Biological Process | GO:0010944 | negative regulation of transcription by competitive promoter binding |
| Biological Process | GO:0021983 | pituitary gland development |
| Biological Process | GO:0043065 | positive regulation of apoptotic process |
| Biological Process | GO:0055025 | positive regulation of cardiac muscle tissue development |
| Biological Process | GO:0045893 | positive regulation of DNA-templated transcription |
| Biological Process | GO:0045600 | positive regulation of fat cell differentiation |
| Biological Process | GO:0046887 | positive regulation of hormone secretion |
| Biological Process | GO:0046889 | positive regulation of lipid biosynthetic process |
| Biological Process | GO:1900273 | positive regulation of long-term synaptic potentiation |
| Biological Process | GO:1904181 | positive regulation of membrane depolarization |
| Biological Process | GO:0040018 | positive regulation of multicellular organism growth |
| Biological Process | GO:0045672 | positive regulation of osteoclast differentiation |
| Biological Process | GO:0045899 | positive regulation of RNA polymerase II transcription preinitiation complex assembly |
| Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| Biological Process | GO:0032916 | positive regulation of transforming growth factor beta3 production |
| Biological Process | GO:0006468 | protein phosphorylation |
| Biological Process | GO:0050821 | protein stabilization |
| Biological Process | GO:0042981 | regulation of apoptotic process |
| Biological Process | GO:0008361 | regulation of cell size |
| Biological Process | GO:0006355 | regulation of DNA-templated transcription |
| Biological Process | GO:0048145 | regulation of fibroblast proliferation |
| Biological Process | GO:0060251 | regulation of glial cell proliferation |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.