Search Results
Overview
| Uniprot ID | P15408 |
|---|---|
| Protein Name | Fos-related antigen 2 |
| Gene Name | FOSL2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 240 | SSSAGLDKAQRSVIK |
Function
Controls osteoclast survival and size (By similarity). As a dimer with JUN, activates LIF transcription (By similarity). Activates CEBPB transcription in PGE2-activated osteoblasts (By similarity)
Protein Sequence
10
MYQDYPGNFD
20
TSSRGSSGSP
30
AHAESYSSGG
40
GGQQKFRVDM
50
PGSGSAFIPT
60
INAITTSQDL
70
QWMVQPTVIT
80
SMSNPYPRSH
90
PYSPLPGLAS
100
VPGHMALPRP
110
GVIKTIGTTV
120
GRRRRDEQLS
130
PEEEEKRRIR
140
RERNKLAAAK
150
CRNRRRELTE
160
KLQAETEELE
170
EEKSGLQKEI
180
AELQKEKEKL
190
EFMLVAHGPV
200
CKISPEERRS
210
PPAPGLQPMR
220
SGGGSVGAVV
230
VKQEPLEEDS
240
PSSSSAGLDK
250
AQRSVIKPIS
260
IAGGFYGEEP
270
LHTPIVVTST
280
PAVTPGTSNL
290
VFTYPSVLEQ
300
ESPASPSESC
310
SKAHRRSSSS
320
GDQSSDSLNS
PTLLAL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0000785 | chromatin |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0035976 | transcription factor AP-1 complex |
| Molecular Function | GO:0003682 | chromatin binding |
| Molecular Function | GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific |
| Molecular Function | GO:0003700 | DNA-binding transcription factor activity |
| Molecular Function | GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific |
| Molecular Function | GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| Molecular Function | GO:0000977 | RNA polymerase II transcription regulatory region sequence-specific DNA binding |
| Biological Process | GO:0008219 | cell death |
| Biological Process | GO:0006351 | DNA-templated transcription |
| Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| Biological Process | GO:0006357 | regulation of transcription by RNA polymerase II |
| Biological Process | GO:0032905 | transforming growth factor beta1 production |
Reference
[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.