Search Results
Overview
| Uniprot ID | P15498 |
|---|---|
| Protein Name | Proto-oncogene vav |
| Gene Name | VAV1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 782 | RPAVGSTKYFGTAKA |
Function
Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation
Protein Sequence
10
MELWRQCTHW
20
LIQCRVLPPS
30
HRVTWDGAQV
40
CELAQALRDG
50
VLLCQLLNNL
60
LPHAINLREV
70
NLRPQMSQFL
80
CLKNIRTFLS
90
TCCEKFGLKR
100
SELFEAFDLF
110
DVQDFGKVIY
120
TLSALSWTPI
130
AQNRGIMPFP
140
TEEESVGDED
150
IYSGLSDQID
160
DTVEEDEDLY
170
DCVENEEAEG
180
DEIYEDLMRS
190
EPVSMPPKMT
200
EYDKRCCCLR
210
EIQQTEEKYT
220
DTLGSIQQHF
230
LKPLQRFLKP
240
QDIEIIFINI
250
EDLLRVHTHF
260
LKEMKEALGT
270
PGAANLYQVF
280
IKYKERFLVY
290
GRYCSQVESA
300
SKHLDRVAAA
310
REDVQMKLEE
320
CSQRANNGRF
330
TLRDLLMVPM
340
QRVLKYHLLL
350
QELVKHTQEA
360
MEKENLRLAL
370
DAMRDLAQCV
380
NEVKRDNETL
390
RQITNFQLSI
400
ENLDQSLAHY
410
GRPKIDGELK
420
ITSVERRSKM
430
DRYAFLLDKA
440
LLICKRRGDS
450
YDLKDFVNLH
460
SFQVRDDSSG
470
DRDNKKWSHM
480
FLLIEDQGAQ
490
GYELFFKTRE
500
LKKKWMEQFE
510
MAISNIYPEN
520
ATANGHDFQM
530
FSFEETTSCK
540
ACQMLLRGTF
550
YQGYRCHRCR
560
ASAHKECLGR
570
VPPCGRHGQD
580
FPGTMKKDKL
590
HRRAQDKKRN
600
ELGLPKMEVF
610
QEYYGLPPPP
620
GAIGPFLRLN
630
PGDIVELTKA
640
EAEQNWWEGR
650
NTSTNEIGWF
660
PCNRVKPYVH
670
GPPQDLSVHL
680
WYAGPMERAG
690
AESILANRSD
700
GTFLVRQRVK
710
DAAEFAISIK
720
YNVEVKHIKI
730
MTAEGLYRIT
740
EKKAFRGLTE
750
LVEFYQQNSL
760
KDCFKSLDTT
770
LQFPFKEPEK
780
RTISRPAVGS
790
TKYFGTAKAR
800
YDFCARDRSE
810
LSLKEGDIIK
820
ILNKKGQQGW
830
WRGEIYGRVG
840
WFPANYVEED
YSEYC
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005911 | cell-cell junction |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005886 | plasma membrane |
| Molecular Function | GO:0005085 | guanyl-nucleotide exchange factor activity |
| Molecular Function | GO:0140031 | phosphorylation-dependent protein binding |
| Molecular Function | GO:0001784 | phosphotyrosine residue binding |
| Molecular Function | GO:0008270 | zinc ion binding |
| Biological Process | GO:0042100 | B cell proliferation |
| Biological Process | GO:0016477 | cell migration |
| Biological Process | GO:0071466 | cellular response to xenobiotic stimulus |
| Biological Process | GO:0038095 | Fc-epsilon receptor signaling pathway |
| Biological Process | GO:0038096 | Fc-gamma receptor signaling pathway involved in phagocytosis |
| Biological Process | GO:0002768 | immune response-regulating cell surface receptor signaling pathway |
| Biological Process | GO:0030101 | natural killer cell activation |
| Biological Process | GO:0042267 | natural killer cell mediated cytotoxicity |
| Biological Process | GO:0030168 | platelet activation |
| Biological Process | GO:0051897 | positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction |
| Biological Process | GO:0008361 | regulation of cell size |
| Biological Process | GO:0051056 | regulation of small GTPase mediated signal transduction |
| Biological Process | GO:0007264 | small GTPase-mediated signal transduction |
| Biological Process | GO:0031295 | T cell costimulation |
| Biological Process | GO:0048010 | vascular endothelial growth factor receptor signaling pathway |
Reference
[1] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.