Search Results

Overview

Uniprot IDP15502
Protein NameElastin
Gene NameELN
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
566 SAAKVAAKAQLRAAA

Function

Major structural protein of tissues such as aorta and nuchal ligament, which must expand rapidly and recover completely. Molecular determinant of the late arterial morphogenesis, stabilizing arterial structure by regulating proliferation and organization of vascular smooth muscle (By similarity)

Protein Sequence

10 MAGLTAAAPR 20 PGVLLLLLSI 30 LHPSRPGGVP 40 GAIPGGVPGG 50 VFYPGAGLGA 60 LGGGALGPGG 70 KPLKPVPGGL 80 AGAGLGAGLG 90 AFPAVTFPGA 100 LVPGGVADAA 110 AAYKAAKAGA 120 GLGGVPGVGG 130 LGVSAGAVVP 140 QPGAGVKPGK 150 VPGVGLPGVY 160 PGGVLPGARF 170 PGVGVLPGVP 180 TGAGVKPKAP 190 GVGGAFAGIP 200 GVGPFGGPQP 210 GVPLGYPIKA 220 PKLPGGYGLP 230 YTTGKLPYGY 240 GPGGVAGAAG 250 KAGYPTGTGV 260 GPQAAAAAAA 270 KAAAKFGAGA 280 AGVLPGVGGA 290 GVPGVPGAIP 300 GIGGIAGVGT 310 PAAAAAAAAA 320 AKAAKYGAAA 330 GLVPGGPGFG 340 PGVVGVPGAG 350 VPGVGVPGAG 360 IPVVPGAGIP 370 GAAVPGVVSP 380 EAAAKAAAKA 390 AKYGARPGVG 400 VGGIPTYGVG 410 AGGFPGFGVG 420 VGGIPGVAGV 430 PGVGGVPGVG 440 GVPGVGISPE 450 AQAAAAAKAA 460 KYGAAGAGVL 470 GGLVPGAPGA 480 VPGVPGTGGV 490 PGVGTPAAAA 500 AKAAAKAAQF 510 GLVPGVGVAP 520 GVGVAPGVGV 530 APGVGLAPGV 540 GVAPGVGVAP 550 GVGVAPGIGP 560 GGVAAAAKSA 570 AKVAAKAQLR 580 AAAGLGAGIP 590 GLGVGVGVPG 600 LGVGAGVPGL 610 GVGAGVPGFG 620 AGADEGVRRS 630 LSPELREGDP 640 SSSQHLPSTP 650 SSPRVPGALA 660 AAKAAKYGAA 670 VPGVLGGLGA 680 LGGVGIPGGV 690 VGAGPAAAAA 700 AAKAAAKAAQ 710 FGLVGAAGLG 720 GLGVGGLGVP 730 GVGGLGGIPP 740 AAAAKAAKYG 750 AAGLGGVLGG 760 AGQFPLGGVA 770 ARPGFGLSPI 780 FPGGACLGKA CGRKRK

Gene Ontology

Classification GO ID Description
Biological Process GO:0009887 animal organ morphogenesis
Cellular Component GO:0071953 elastic fiber
Cellular Component GO:0031012 extracellular matrix
Cellular Component GO:0005576 extracellular region
Molecular Function GO:0050840 extracellular matrix binding
Molecular Function GO:0030023 extracellular matrix constituent conferring elasticity
Molecular Function GO:0005201 extracellular matrix structural constituent
Biological Process GO:0003180 aortic valve morphogenesis
Biological Process GO:0008015 blood circulation
Biological Process GO:0085029 extracellular matrix assembly
Biological Process GO:0003151 outflow tract morphogenesis
Biological Process GO:0048660 regulation of smooth muscle cell proliferation
Biological Process GO:0007585 respiratory gaseous exchange by respiratory system

Reference

[1] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.