Overview
| Uniprot ID | P15529 |
|---|
| Protein Name | Membrane cofactor protein |
|---|
| Gene Name | CD46 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 167 |
VLCTPPPKIKNGKHT |
Function
Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity
Protein Sequence
10
MEPPGRRECP
20
FPSWRFPGLL
30
LAAMVLLLYS
40
FSDACEEPPT
50
FEAMELIGKP
60
KPYYEIGERV
70
DYKCKKGYFY
80
IPPLATHTIC
90
DRNHTWLPVS
100
DDACYRETCP
110
YIRDPLNGQA
120
VPANGTYEFG
130
YQMHFICNEG
140
YYLIGEEILY
150
CELKGSVAIW
160
SGKPPICEKV
170
LCTPPPKIKN
180
GKHTFSEVEV
190
FEYLDAVTYS
200
CDPAPGPDPF
210
SLIGESTIYC
220
GDNSVWSRAA
230
PECKVVKCRF
240
PVVENGKQIS
250
GFGKKFYYKA
260
TVMFECDKGF
270
YLDGSDTIVC
280
DSNSTWDPPV
290
PKCLKVLPPS
300
STKPPALSHS
310
VSTSSTTKSP
320
ASSASGPRPT
330
YKPPVSNYPG
340
YPKPEEGILD
350
SLDVWVIAVI
360
VIAIVVGVAV
370
ICVVPYRYLQ
380
RRKKKGTYLT
390
DETHREVKFT
SL
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0009986 |
cell surface |
| Cellular Component |
GO:0070062 |
extracellular exosome |
| Cellular Component |
GO:0005615 |
extracellular space |
| Cellular Component |
GO:0005925 |
focal adhesion |
| Cellular Component |
GO:0002079 |
inner acrosomal membrane |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Molecular Function |
GO:0045296 |
cadherin binding |
| Molecular Function |
GO:0038023 |
signaling receptor activity |
| Molecular Function |
GO:0001618 |
virus receptor activity |
| Biological Process |
GO:0002250 |
adaptive immune response |
| Biological Process |
GO:0006958 |
complement activation, classical pathway |
| Biological Process |
GO:0045087 |
innate immune response |
| Biological Process |
GO:0045959 |
negative regulation of complement activation, classical pathway |
| Biological Process |
GO:0010629 |
negative regulation of gene expression |
| Biological Process |
GO:0010628 |
positive regulation of gene expression |
| Biological Process |
GO:0032733 |
positive regulation of interleukin-10 production |
| Biological Process |
GO:0043382 |
positive regulation of memory T cell differentiation |
| Biological Process |
GO:0045591 |
positive regulation of regulatory T cell differentiation |
| Biological Process |
GO:0042102 |
positive regulation of T cell proliferation |
| Biological Process |
GO:0071636 |
positive regulation of transforming growth factor beta production |
| Biological Process |
GO:0008593 |
regulation of Notch signaling pathway |
| Biological Process |
GO:0035581 |
sequestering of extracellular ligand from receptor |
| Biological Process |
GO:0007338 |
single fertilization |
| Biological Process |
GO:0002456 |
T cell mediated immunity |
Reference
[1] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.