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Overview

Uniprot IDP15822
Protein NameZinc finger protein 40
Gene NameHIVEP1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1175 TGKSGSLKVIGISQE
1271 QRSETLSKLPTEKLP
46 KGTSESLKGVKRKKI
625 TNENSHQKGDMNPLE
750 TLEERISKLISDNEA
938 EAMSVRSKALAQGPH
949 QGPHIEKKKSHQGRG

Function

This protein specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV-1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, and interferon-beta genes. It may act in T-cell activation. Involved in activating HIV-1 gene expression. Isoform 2 and isoform 3 also bind to the IPCS (IRF1 and p53 common sequence) DNA sequence in the promoter region of interferon regulatory factor 1 and p53 genes and are involved in transcription regulation of these genes. Isoform 2 does not activate HIV-1 gene expression. Isoform 2 and isoform 3 may be involved in apoptosis

Protein Sequence

10 MPRTKQIHPR 20 NLRDKIEEAQ 30 KELNGAEVSK 40 KEILQAGVKG 50 TSESLKGVKR 60 KKIVAENHLK 70 KIPKSPLRNP 80 LQAKHKQNTE 90 ESSFAVLHSA 100 SESHKKQNYI 110 PVKNGKQFTK 120 QNGETPGIIA 130 EASKSEESVS 140 PKKPLFLQQP 150 SELRRWRSEG 160 ADPAKFSDLD 170 EQCDSSSLSS 180 KTRTDNSECI 190 SSHCGTTSPS 200 YTNTAFDVLL 210 KAMEPELSTL 220 SQKGSPCAIK 230 TEKLRPNKTA 240 RSPPKLKNSS 250 MDAPNQTSQE 260 LVAESQSSCT 270 SYTVHMSAAQ 280 KNEQGAMQSA 290 SHLYHQHEHF 300 VPKSNQHNQQ 310 LPGCSGFTGS 320 LTNLQNQENA 330 KLEQVYNIAV 340 TSSVGLTSPS 350 SRSQVTPQNQ 360 QMDSASPLSI 370 SPANSTQSPP 380 MPIYNSTHVA 390 SVVNQSVEQM 400 CNLLLKDQKP 410 KKQGKYICEY 420 CNRACAKPSV 430 LLKHIRSHTG 440 ERPYPCVTCG 450 FSFKTKSNLY 460 KHKKSHAHTI 470 KLGLVLQPDA 480 GGLFLSHESP 490 KALSIHSDVE 500 DSGESEEEGA 510 TDERQHDLGA 520 MELQPVHIIK 530 RMSNAETLLK 540 SSFTPSSPEN 550 VIGDFLLQDR 560 SAESQAVTEL 570 PKVVVHHVTV 580 SPLRTDSPKA 590 MDPKPELSSA 600 QKQKDLQVTN 610 VQPLSANMSQ 620 GGVSRLETNE 630 NSHQKGDMNP 640 LEGKQDSHVG 650 TVHAQLQRQQ 660 ATDYSQEQQG 670 KLLSPRSLGS 680 TDSGYFSRSE 690 SADQTVSPPT 700 PFARRLPSTE 710 QDSGRSNGPS 720 AALVTTSTPS 730 ALPTGEKALL 740 LPGQMRPPLA 750 TKTLEERISK 760 LISDNEALVD 770 DKQLDSVKPR 780 RTSLSRRGSI 790 DSPKSYIFKD 800 SFQFDLKPVG 810 RRTSSSSDIP 820 KSPFTPTEKS 830 KQVFLLSVPS 840 LDCLPITRSN 850 SMPTTGYSAV 860 PANIIPPPHP 870 LRGSQSFDDK 880 IGAFYDDVFV 890 SGPNAPVPQS 900 GHPRTLVRQA 910 AIEDSSANES 920 HVLGTGQSLD 930 ESHQGCHAAG 940 EAMSVRSKAL 950 AQGPHIEKKK 960 SHQGRGTMFE 970 CETCRNRYRK 980 LENFENHKKF 990 YCSELHGPKT 1000 KVAMREPEHS 1010 PVPGGLQPQI 1020 LHYRVAGSSG 1030 IWEQTPQIRK 1040 RRKMKSVGDD 1050 EELQQNESGT 1060 SPKSSEGLQF 1070 QNALGCNPSL 1080 PKHNVTIRSD 1090 QQHKNIQLQN 1100 SHIHLVARGP 1110 EQTMDPKLST 1120 IMEQQISSAA 1130 QDKIELQRHG 1140 TGISVIQHTN 1150 SLSRPNSFDK 1160 PEPFERASPV 1170 SFQELNRTGK 1180 SGSLKVIGIS 1190 QEESHPSRDG 1200 SHPHQLALSD 1210 ALRGELQESS 1220 RKSPSERHVL 1230 GQPSRLVRQH 1240 NIQVPEILVT 1250 EEPDRDLEAQ 1260 CHDQEKSEKF 1270 SWPQRSETLS 1280 KLPTEKLPPK 1290 KKRLRLAEIE 1300 HSSTESSFDS 1310 TLSRSLSRES 1320 SLSHTSSFSA 1330 SLDIEDVSKT 1340 EASPKIDFLN 1350 KAEFLMIPAG 1360 LNTLNVPGCH 1370 REMRRTASEQ 1380 INCTQTSMEV 1390 SDLRSKSFDC 1400 GSITPPQTTP 1410 LTELQPPSSP 1420 SRVGVTGHVP 1430 LLERRRGPLV 1440 RQISLNIAPD 1450 SHLSPVHPTS 1460 FQNTALPSVN 1470 AVPYQGPQLT 1480 STSLAEFSAN 1490 TLHSQTQVKD 1500 LQAETSNSSS 1510 TNVFPVQQLC 1520 DINLLNQIHA 1530 PPSHQSTQLS 1540 LQVSTQGSKP 1550 DKNSVLSGSS 1560 KSEDCFAPKY 1570 QLHCQVFTSG 1580 PSCSSNPVHS 1590 LPNQVISDPV 1600 GTDHCVTSAT 1610 LPTKLIDSMS 1620 NSHPLLPPEL 1630 RPLGSQVQKV 1640 PSSFMLPIRL 1650 QSSVPAYCFA 1660 TLTSLPQILV 1670 TQDLPNQPIC 1680 QTNHSVVPIS 1690 EEQNSVPTLQ 1700 KGHQNALPNP 1710 EKEFLCENVF 1720 SEMSQNSSLS 1730 ESLPITQKIS 1740 VGRLSPQQES 1750 SASSKRMLSP 1760 ANSLDIAMEK 1770 HQKRAKDENG 1780 AVCATDVRPL 1790 EALSSRVNEA 1800 SKQKKPILVR 1810 QVCTTEPLDG 1820 VMLEKDVFSQ 1830 PEISNEAVNL 1840 TNVLPADNSS 1850 TGCSKFVVIE 1860 PISELQEFEN 1870 IKSSTSLTLT 1880 VRSSPAPSEN 1890 THISPLKCTD 1900 NNQERKSPGV 1910 KNQGDKVNIQ 1920 EQSQQPVTSL 1930 SLFNIKDTQQ 1940 LAFPSLKTTT 1950 NFTWCYLLRQ 1960 KSLHLPQKDQ 1970 KTSAYTDWTV 1980 SASNPNPLGL 1990 PTKVALALLN 2000 SKQNTGKSLY 2010 CQAITTHSKS 2020 DLLVYSSKWK 2030 SSLSKRALGN 2040 QKSTVVEFSN 2050 KDASEINSEQ 2060 DKENSLIKSE 2070 PRRIKIFDGG 2080 YKSNEEYVYV 2090 RGRGRGKYIC 2100 EECGIRCKKP 2110 SMLKKHIRTH 2120 TDVRPYHCTY 2130 CNFSFKTKGN 2140 LTKHMKSKAH 2150 SKKCVDLGVS 2160 VGLIDEQDTE 2170 ESDEKQRFSY 2180 ERSGYDLEES 2190 DGPDEDDNEN 2200 EDDDEDSQAE 2210 SVLSATPSVT 2220 ASPQHLPSRS 2230 SLQDPVSTDE 2240 DVRITDCFSG 2250 VHTDPMDVLP 2260 RALLTRMTVL 2270 STAQSDYNRK 2280 TLSPGKARQR 2290 AARDENDTIP 2300 SVDTSRSPCH 2310 QMSVDYPESE 2320 EILRSSMAGK 2330 AVAITQSPSS 2340 VRLPPAAAEH 2350 SPQTAAGMPS 2360 VASPHPDPQE 2370 QKQQITLQPT 2380 PGLPSPHTHL 2390 FSHLPLHSQQ 2400 QSRTPYNMVP 2410 VGGIHVVPAG 2420 LTYSTFVPLQ 2430 AGPVQLTIPA 2440 VSVVHRTLGT 2450 HRNTVTEVSG 2460 TTNPAGVAEL 2470 SSVVPCIPIG 2480 QIRVPGLQNL 2490 STPGLQSLPS 2500 LSMETVNIVG 2510 LANTNMAPQV 2520 HPPGLALNAV 2530 GLQVLTANPS 2540 SQSSPAPQAH 2550 IPGLQILNIA 2560 LPTLIPSVSQ 2570 VAVDAQGAPE 2580 MPASQSKACE 2590 TQPKQTSVAS 2600 ANQVSRTESP 2610 QGLPTVQREN 2620 AKKVLNPPAP 2630 AGDHARLDGL 2640 SKMDTEKAAS 2650 ANHVKPKPEL 2660 TSIQGQPAST 2670 SQPLLKAHSE 2680 VFTKPSGQQT 2690 LSPDRQVPRP 2700 TALPRRQPTV 2710 HFSDVSSDDD EDRLVIAT

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0016604 nuclear body
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
Molecular Function GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
Molecular Function GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
Molecular Function GO:1990837 sequence-specific double-stranded DNA binding
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0030509 BMP signaling pathway
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0006357 regulation of transcription by RNA polymerase II

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.