Overview
| Uniprot ID | P15864 |
|---|
| Protein Name | Histone H1.2 |
|---|
| Gene Name | H1-2 |
|---|
| Organism | Mus musculus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 64 |
VSLAALKKALAAAGY |
Function
Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber (PubMed:12808097, PubMed:16377562). Histone H1-2 is required for the condensation of nucleosome chains into higher-order structured fibers (PubMed:12808097, PubMed:16377562). Histone H1-2 also acts as a histone reader: specifically recognizes and binds histone H3 trimethylated at 'lys-27' (H3K27me3) (By similarity). Histones H1 also promote formation of the H3K27me3 mark by the PRC2/EED-EZH2 complex, possibly by facilitating restoration of H3K27me3 post-replication (By similarity). Together with histone H1-3, histone H1-2 acts as a regulator of splicing, most specifically exon skipping and intron retention events: histone H1-2 has a high affinity for exons and regulates splicing by affecting RNA polymerase II (RNAPII) elongation (By similarity). Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity)
Protein Sequence
10
MSEAAPAAPA
20
AAPPAEKAPA
30
KKKAAKKPAG
40
VRRKASGPPV
50
SELITKAVAA
60
SKERSGVSLA
70
ALKKALAAAG
80
YDVEKNNSRI
90
KLGLKSLVSK
100
GILVQTKGTG
110
ASGSFKLNKK
120
AASGEAKPQA
130
KKAGAAKAKK
140
PAGAAKKPKK
150
ATGAATPKKA
160
AKKTPKKAKK
170
PAAAAVTKKV
180
AKSPKKAKVT
190
KPKKVKSASK
200
AVKPKAAKPK
210
VAKAKKVAAK
KK
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0000791 |
euchromatin |
| Cellular Component |
GO:0000792 |
heterochromatin |
| Cellular Component |
GO:0005730 |
nucleolus |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0000786 |
nucleosome |
| Cellular Component |
GO:0005634 |
nucleus |
| Molecular Function |
GO:0003690 |
double-stranded DNA binding |
| Molecular Function |
GO:0061628 |
histone H3K27me3 reader activity |
| Molecular Function |
GO:0031492 |
nucleosomal DNA binding |
| Molecular Function |
GO:0030527 |
structural constituent of chromatin |
| Biological Process |
GO:0030261 |
chromosome condensation |
| Biological Process |
GO:0140718 |
facultative heterochromatin formation |
| Biological Process |
GO:0045910 |
negative regulation of DNA recombination |
| Biological Process |
GO:0006334 |
nucleosome assembly |
| Biological Process |
GO:0048024 |
regulation of mRNA splicing, via spliceosome |
Reference
[1] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.