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Overview

Uniprot IDP15865
Protein NameHistone H1.4
Gene NameH1-4
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
106 TGASGSFKLNKKAAS
34 AAGGAKRKASGPPVS
64 VSLAALKKALAAAGY
75 AAGYDVEKNNSRIKL
90 GLKSLVSKGTLVQTK
97 KGTLVQTKGTGASGS

Function

Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers and promote formation of the H3K27me3 mark by the PRC2/EED-EZH2 complex. Ability to associate with nucleosomes and compact chromatin depends on linker DNA length and trajectory. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation

Protein Sequence

10 MSETAPAAPA 20 APAPAEKTPI 30 KKKARKAAGG 40 AKRKASGPPV 50 SELITKAVAA 60 SKERSGVSLA 70 ALKKALAAAG 80 YDVEKNNSRI 90 KLGLKSLVSK 100 GTLVQTKGTG 110 ASGSFKLNKK 120 AASGEAKPKA 130 KKAGAAKAKK 140 PAGAAKKPKK 150 ATGTATPKKS 160 TKKTPKKAKK 170 PAAAAGAKKA 180 KSPKKAKATK 190 AKKAPKSPAK 200 ARAVKPKAAK 210 PKTSKPKAAK PKKTAAKKK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0000785 chromatin
Cellular Component GO:0000791 euchromatin
Cellular Component GO:0000792 heterochromatin
Cellular Component GO:0016607 nuclear speck
Cellular Component GO:0000786 nucleosome
Cellular Component GO:0005634 nucleus
Molecular Function GO:0043531 ADP binding
Molecular Function GO:0016208 AMP binding
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0005509 calcium ion binding
Molecular Function GO:0031490 chromatin DNA binding
Molecular Function GO:0032564 dATP binding
Molecular Function GO:0003677 DNA binding
Molecular Function GO:0003690 double-stranded DNA binding
Molecular Function GO:0005525 GTP binding
Molecular Function GO:0042826 histone deacetylase binding
Molecular Function GO:0031492 nucleosomal DNA binding
Molecular Function GO:0000166 nucleotide binding
Molecular Function GO:0030527 structural constituent of chromatin
Biological Process GO:0030261 chromosome condensation
Biological Process GO:0045910 negative regulation of DNA recombination
Biological Process GO:0006334 nucleosome assembly

Reference

[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.

[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.