Search Results

Overview

Uniprot ID	P15907
Protein Name	Beta-galactoside alpha-2,6-sialyltransferase 1
Gene Name	ST6GAL1
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
177	PKESIRTKAGPWGRC
241	SQLVTTEKRFLKDSL
349	EFLPSKRKTDVCYYY

Function

Transfers sialic acid from CMP-sialic acid to galactose-containing acceptor substrates. In B lymphocytes, generates neuraminidase-sensitive lymphocyte cell-surface differentiation antigens, such as CDw75, HB-6 and CD76 (PubMed:1730763). Sialylates complex-type N-glycans attached on the fragment crystallizable (Fc) of IgGs confering anti-inflammatory effector functions. Preferentially monosialylates the alpha(1->3) mannose antenna of Fc glycoforms with subsequent disialylation occurring at a much slower rate

Protein Sequence

10 MIHTNLKKKF 20 SCCVLVFLLF 30 AVICVWKEKK 40 KGSYYDSFKL 50 QTKEFQVLKS 60 LGKLAMGSDS 70 QSVSSSSTQD 80 PHRGRQTLGS 90 LRGLAKAKPE 100 ASFQVWNKDS 110 SSKNLIPRLQ 120 KIWKNYLSMN 130 KYKVSYKGPG 140 PGIKFSAEAL 150 RCHLRDHVNV 160 SMVEVTDFPF 170 NTSEWEGYLP 180 KESIRTKAGP 190 WGRCAVVSSA 200 GSLKSSQLGR 210 EIDDHDAVLR 220 FNGAPTANFQ 230 QDVGTKTTIR 240 LMNSQLVTTE 250 KRFLKDSLYN 260 EGILIVWDPS 270 VYHSDIPKWY 280 QNPDYNFFNN 290 YKTYRKLHPN 300 QPFYILKPQM 310 PWELWDILQE 320 ISPEEIQPNP 330 PSSGMLGIII 340 MMTLCDQVDI 350 YEFLPSKRKT 360 DVCYYYQKFF 370 DSACTMGAYH 380 PLLYEKNLVK 390 HLNQGTDEDI 400 YLLGKATLPG FRTIHC

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005576	extracellular region
Cellular Component	GO:0005794	Golgi apparatus
Cellular Component	GO:0032580	Golgi cisterna membrane
Cellular Component	GO:0000139	Golgi membrane
Molecular Function	GO:0003835	beta-galactoside alpha-2,6-sialyltransferase activity
Molecular Function	GO:0042803	protein homodimerization activity
Molecular Function	GO:0008373	sialyltransferase activity
Biological Process	GO:0006054	N-acetylneuraminate metabolic process
Biological Process	GO:0006487	protein N-linked glycosylation
Biological Process	GO:0016266	protein O-linked glycosylation via N-acetyl-galactosamine
Biological Process	GO:0097503	sialylation
Biological Process	GO:0019082	viral protein processing

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.