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Overview

Uniprot IDP15923
Protein NameTranscription factor E2-alpha
Gene NameTCF3
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
171 GSLDTQPKKVRKVPP
172 SLDTQPKKVRKVPPG
175 TQPKKVRKVPPGLPS
614 RERNLNPKAACLKRR

Function

Transcriptional regulator involved in the initiation of neuronal differentiation and mesenchymal to epithelial transition (By similarity). Heterodimers between TCF3 and tissue-specific basic helix-loop-helix (bHLH) proteins play major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation (By similarity). Together with TCF15, required for the mesenchymal to epithelial transition (By similarity). Dimers bind DNA on E-box motifs: 5'-CANNTG-3' (By similarity). Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer (PubMed:2493990). Binds to IEB1 and IEB2, which are short DNA sequences in the insulin gene transcription control region (By similarity)

Protein Sequence

10 MNQPQRMAPV 20 GTDKELSDLL 30 DFSMMFPLPV 40 TNGKGRPASL 50 AGAQFGGSGL 60 EDRPSSGSWG 70 SGDQSSSSFD 80 PSRTFSEGTH 90 FTESHSSLSS 100 STFLGPGLGG 110 KSGERGAYAS 120 FGRDAGVGGL 130 TQAGFLSGEL 140 ALNSPGPLSP 150 SGMKGTSQYY 160 PSYSGSSRRR 170 AADGSLDTQP 180 KKVRKVPPGL 190 PSSVYPPSSG 200 EDYGRDATAY 210 PSAKTPSSTY 220 PAPFYVADGS 230 LHPSAELWSP 240 PGQAGFGPML 250 GGGSSPLPLP 260 PGSGPVGSSG 270 SSSTFGGLHQ 280 HERMGYQLHG 290 AEVNGGLPSA 300 SSFSSAPGAT 310 YGGVSSHTPP 320 VSGADSLLGS 330 RGTTAGSSGD 340 ALGKALASIY 350 SPDHSSNNFS 360 SSPSTPVGSP 370 QGLAGTSQWP 380 RAGAPGALSP 390 SYDGGLHGLQ 400 SKIEDHLDEA 410 IHVLRSHAVG 420 TAGDMHTLLP 430 GHGALASGFT 440 GPMSLGGRHA 450 GLVGGSHPED 460 GLAGSTSLMH 470 NHAALPSQPG 480 TLPDLSRPPD 490 SYSGLGRAGA 500 TAAASEIKRE 510 EKEDEENTSA 520 ADHSEEEKKE 530 LKAPRARTSP 540 DEDEDDLLPP 550 EQKAEREKER 560 RVANNARERL 570 RVRDINEAFK 580 ELGRMCQLHL 590 NSEKPQTKLL 600 ILHQAVSVIL 610 NLEQQVRERN 620 LNPKAACLKR 630 REEEKVSGVV 640 GDPQMVLSAP 650 HPGLSEAHNP AGHM

Gene Ontology

Classification GO ID Description
Cellular Component GO:0000785 chromatin
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0000791 euchromatin
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0032991 protein-containing complex
Cellular Component GO:0090575 RNA polymerase II transcription regulator complex
Cellular Component GO:0005667 transcription regulator complex
Molecular Function GO:0043425 bHLH transcription factor binding
Molecular Function GO:0000987 cis-regulatory region sequence-specific DNA binding
Molecular Function GO:0003677 DNA binding
Molecular Function GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
Molecular Function GO:0003700 DNA-binding transcription factor activity
Molecular Function GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
Molecular Function GO:0140297 DNA-binding transcription factor binding
Molecular Function GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
Molecular Function GO:0070888 E-box binding
Molecular Function GO:0031435 mitogen-activated protein kinase kinase kinase binding
Molecular Function GO:0046982 protein heterodimerization activity
Molecular Function GO:0042803 protein homodimerization activity
Molecular Function GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
Molecular Function GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding
Molecular Function GO:0070644 vitamin D response element binding
Biological Process GO:0030183 B cell differentiation
Biological Process GO:0002326 B cell lineage commitment
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0033152 immunoglobulin V(D)J recombination
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0007399 nervous system development
Biological Process GO:0030890 positive regulation of B cell proliferation
Biological Process GO:0045787 positive regulation of cell cycle
Biological Process GO:0045893 positive regulation of DNA-templated transcription
Biological Process GO:0045666 positive regulation of neuron differentiation
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0006355 regulation of DNA-templated transcription
Biological Process GO:2000045 regulation of G1/S transition of mitotic cell cycle
Biological Process GO:0006357 regulation of transcription by RNA polymerase II

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.