Search Results

Overview

Uniprot IDP15924
Protein NameDesmoplakin
Gene NameDSP
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1033 DLKLKNTKIEVLEEE
1144 NDYDQLQKARQCEKE
1150 QKARQCEKENLGWQK
167 RVRRASSKGGGGYTC
1802 SNRIQESKNQCTQVV
2026 AGASASPKEKYSLVE
2179 FVDPVTKKKVSYVQL
2180 VDPVTKKKVSYVQLK
2458 KQVQTSQKNTLRKRR
2592 SRHESVSKISTISSV
322 RMSQLEVKEKELNKL
478 QDQKIVHKGDECILK
959 ELCANSIKDYELQLA

Function

A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:25733715). Critical for cell-cell adhesion in early stage blastocysts and progression through proamniotic cavity formation (By similarity). Not required for preimplantation morphogenic process in blastocysts (By similarity). Required for keratin filament anchoring at the desmosome junction and subsequent organization of the keratin intermediate filament network within the cytoplasm (By similarity). Required for anchoring of desmosomes to the microtubule architecture, via its interaction with NIN (By similarity). Promotes microtubule-mediated GJA1/CX43 trafficking to cell membranes via its interaction with MAPRE1/EB1, thereby facilitating gap junction intracellular communication (PubMed:25225338). Plays a key role in adhesion and organization of the dermal epithelial barrier (PubMed:26604139). Critical for the maintenance of the neural tube structure following formation and organization of the neuroepithelium (By similarity). Facilitates outgrowth and repair of motor neuron fibers in regenerating axons following injury, probably by promoting recruitment of a complex containing DSP, CDH2, VIM and JUP to the outgrowth tips (By similarity). Critical for the normal formation of heart and myocardial tissue during early embryogenesis (By similarity). Also required for development of vascular capillary structures and intact endothelial cell barriers (By similarity). Regulates profibrotic gene expression in cardiomyocytes via activation of the MAPK14/p38 MAPK signaling cascade and increase in TGFB1 protein abundance (By similarity). Maintains cardiac rhythmicity by ensuring correct cell-cell adhesion within the sinoatrial node, via stabilization of protein components of both desmosome and Gap junctions (By similarity). Involved in maintaining the protein stability and recruitment of GJA1 to functional gap junctions, via inhibition of KRAS-mediated MAPK1/MAPK3 phosphorylation of GJA1 (By similarity). Negative regulator of cell cycle progression and differentiation in keratinocytes, potentially via inhibition of MAPK and phosphoinositide-3-kinase (PI3K) signaling pathways (PubMed:17475244). Mediates the interaction between the desmosome and COP9 signalosome complex (CSN) protein complex (PubMed:28891468). As a result of this interaction, promotes keratinocyte differentiation via deneddylation of EGFR resulting in a reduction in EGFR protein stabilization and translocation away from the cell membrane (PubMed:28891468). Required for the maintenance of protein abundance of desmosome junction components DSG1, DSG2, DSC2, DSC3, PKP1, PKP2 and PKP3 (PubMed:17475244, PubMed:26073755). Required for the survival and maintenance of germ cells in the gonads during embryonic development (By similarity). Binds to telomere DNA (via C-terminus) and acts to prevent telomere damage and maintain telomere length via its interaction with TRF2 (PubMed:31595153)

Protein Sequence

10 MSCNGGSHPR 20 INTLGRMIRA 30 ESGPDLRYEV 40 TSGGGGTSRM 50 YYSRRGVITD 60 QNSDGYCQTG 70 TMSRHQNQNT 80 IQELLQNCSD 90 CLMRAELIVQ 100 PELKYGDGIQ 110 LTRSRELDEC 120 FAQANDQMEI 130 LDSLIREMRQ 140 MGQPCDAYQK 150 RLLQLQEQMR 160 ALYKAISVPR 170 VRRASSKGGG 180 GYTCQSGSGW 190 DEFTKHVTSE 200 CLGWMRQQRA 210 EMDMVAWGVD 220 LASVEQHINS 230 HRGIHNSIGD 240 YRWQLDKIKA 250 DLREKSAIYQ 260 LEEEYENLLK 270 ASFERMDHLR 280 QLQNIIQATS 290 REIMWINDCE 300 EEELLYDWSD 310 KNTNIAQKQE 320 AFSIRMSQLE 330 VKEKELNKLK 340 QESDQLVLNQ 350 HPASDKIEAY 360 MDTLQTQWSW 370 ILQITKCIDV 380 HLKENAAYFQ 390 FFEEAQSTEA 400 YLKGLQDSIR 410 KKYPCDKNMP 420 LQHLLEQIKE 430 LEKEREKILE 440 YKRQVQNLVN 450 KSKKIVQLKP 460 RNPDYRSNKP 470 IILRALCDYK 480 QDQKIVHKGD 490 ECILKDNNER 500 SKWYVTGPGG 510 VDMLVPSVGL 520 IIPPPNPLAV 530 DLSCKIEQYY 540 EAILALWNQL 550 YINMKSLVSW 560 HYCMIDIEKI 570 RAMTIAKLKT 580 MRQEDYMKTI 590 ADLELHYQEF 600 IRNSQGSEMF 610 GDDDKRKIQS 620 QFTDAQKHYQ 630 TLVIQLPGYP 640 QHQTVTTTEI 650 THHGTCQDVN 660 HNKVIETNRE 670 NDKQETWMLM 680 ELQKIRRQIE 690 HCEGRMTLKN 700 LPLADQGSSH 710 HITVKINELK 720 SVQNDSQAIA 730 EVLNQLKDML 740 ANFRGSEKYC 750 YLQNEVFGLF 760 QKLENINGVT 770 DGYLNSLCTV 780 RALLQAILQT 790 EDMLKVYEAR 800 LTEEETVCLD 810 LDKVEAYRCG 820 LKKIKNDLNL 830 KKSLLATMKT 840 ELQKAQQIHS 850 QTSQQYPLYD 860 LDLGKFGEKV 870 TQLTDRWQRI 880 DKQIDFRLWD 890 LEKQIKQLRN 900 YRDNYQAFCK 910 WLYDAKRRQD 920 SLESMKFGDS 930 NTVMRFLNEQ 940 KNLHSEISGK 950 RDKSEEVQKI 960 AELCANSIKD 970 YELQLASYTS 980 GLETLLNIPI 990 KRTMIQSPSG 1000 VILQEAADVH 1010 ARYIELLTRS 1020 GDYYRFLSEM 1030 LKSLEDLKLK 1040 NTKIEVLEEE 1050 LRLARDANSE 1060 NCNKNKFLDQ 1070 NLQKYQAECS 1080 QFKAKLASLE 1090 ELKRQAELDG 1100 KSAKQNLDKC 1110 YGQIKELNEK 1120 ITRLTYEIED 1130 EKRRRKSVED 1140 RFDQQKNDYD 1150 QLQKARQCEK 1160 ENLGWQKLES 1170 EKAIKEKEYE 1180 IERLRVLLQE 1190 EGTRKREYEN 1200 ELAKVRNHYN 1210 EEMSNLRNKY 1220 ETEINITKTT 1230 IKEISMQKED 1240 DSKNLRNQLD 1250 RLSRENRDLK 1260 DEIVRLNDSI 1270 LQATEQRRRA 1280 EENALQQKAC 1290 GSEIMQKKQH 1300 LEIELKQVMQ 1310 QRSEDNARHK 1320 QSLEEAAKTI 1330 QDKNKEIERL 1340 KAEFQEEAKR 1350 RWEYENELSK 1360 VRNNYDEEII 1370 SLKNQFETEI 1380 NITKTTIHQL 1390 TMQKEEDTSG 1400 YRAQIDNLTR 1410 ENRSLSEEIK 1420 RLKNTLTQTT 1430 ENLRRVEEDI 1440 QQQKATGSEV 1450 SQRKQQLEVE 1460 LRQVTQMRTE 1470 ESVRYKQSLD 1480 DAAKTIQDKN 1490 KEIERLKQLI 1500 DKETNDRKCL 1510 EDENARLQRV 1520 QYDLQKANSS 1530 ATETINKLKV 1540 QEQELTRLRI 1550 DYERVSQERT 1560 VKDQDITRFQ 1570 NSLKELQLQK 1580 QKVEEELNRL 1590 KRTASEDSCK 1600 RKKLEEELEG 1610 MRRSLKEQAI 1620 KITNLTQQLE 1630 QASIVKKRSE 1640 DDLRQQRDVL 1650 DGHLREKQRT 1660 QEELRRLSSE 1670 VEALRRQLLQ 1680 EQESVKQAHL 1690 RNEHFQKAIE 1700 DKSRSLNESK 1710 IEIERLQSLT 1720 ENLTKEHLML 1730 EEELRNLRLE 1740 YDDLRRGRSE 1750 ADSDKNATIL 1760 ELRSQLQISN 1770 NRTLELQGLI 1780 NDLQRERENL 1790 RQEIEKFQKQ 1800 ALEASNRIQE 1810 SKNQCTQVVQ 1820 ERESLLVKIK 1830 VLEQDKARLQ 1840 RLEDELNRAK 1850 STLEAETRVK 1860 QRLECEKQQI 1870 QNDLNQWKTQ 1880 YSRKEEAIRK 1890 IESEREKSER 1900 EKNSLRSEIE 1910 RLQAEIKRIE 1920 ERCRRKLEDS 1930 TRETQSQLET 1940 ERSRYQREID 1950 KLRQRPYGSH 1960 RETQTECEWT 1970 VDTSKLVFDG 1980 LRKKVTAMQL 1990 YECQLIDKTT 2000 LDKLLKGKKS 2010 VEEVASEIQP 2020 FLRGAGSIAG 2030 ASASPKEKYS 2040 LVEAKRKKLI 2050 SPESTVMLLE 2060 AQAATGGIID 2070 PHRNEKLTVD 2080 SAIARDLIDF 2090 DDRQQIYAAE 2100 KAITGFDDPF 2110 SGKTVSVSEA 2120 IKKNLIDRET 2130 GMRLLEAQIA 2140 SGGVVDPVNS 2150 VFLPKDVALA 2160 RGLIDRDLYR 2170 SLNDPRDSQK 2180 NFVDPVTKKK 2190 VSYVQLKERC 2200 RIEPHTGLLL 2210 LSVQKRSMSF 2220 QGIRQPVTVT 2230 ELVDSGILRP 2240 STVNELESGQ 2250 ISYDEVGERI 2260 KDFLQGSSCI 2270 AGIYNETTKQ 2280 KLGIYEAMKI 2290 GLVRPGTALE 2300 LLEAQAATGF 2310 IVDPVSNLRL 2320 PVEEAYKRGL 2330 VGIEFKEKLL 2340 SAERAVTGYN 2350 DPETGNIISL 2360 FQAMNKELIE 2370 KGHGIRLLEA 2380 QIATGGIIDP 2390 KESHRLPVDI 2400 AYKRGYFNEE 2410 LSEILSDPSD 2420 DTKGFFDPNT 2430 EENLTYLQLK 2440 ERCIKDEETG 2450 LCLLPLKEKK 2460 KQVQTSQKNT 2470 LRKRRVVIVD 2480 PETNKEMSVQ 2490 EAYKKGLIDY 2500 ETFKELCEQE 2510 CEWEEITITG 2520 SDGSTRVVLV 2530 DRKTGSQYDI 2540 QDAIDKGLVD 2550 RKFFDQYRSG 2560 SLSLTQFADM 2570 ISLKNGVGTS 2580 SSMGSGVSDD 2590 VFSSSRHESV 2600 SKISTISSVR 2610 NLTIRSSSFS 2620 DTLEESSPIA 2630 AIFDTENLEK 2640 ISITEGIERG 2650 IVDSITGQRL 2660 LEAQACTGGI 2670 IHPTTGQKLS 2680 LQDAVSQGVI 2690 DQDMATRLKP 2700 AQKAFIGFEG 2710 VKGKKKMSAA 2720 EAVKEKWLPY 2730 EAGQRFLEFQ 2740 YLTGGLVDPE 2750 VHGRISTEEA 2760 IRKGFIDGRA 2770 AQRLQDTSSY 2780 AKILTCPKTK 2790 LKISYKDAIN 2800 RSMVEDITGL 2810 RLLEAASVSS 2820 KGLPSPYNMS 2830 SAPGSRSGSR 2840 SGSRSGSRSG 2850 SRSGSRRGSF 2860 DATGNSSYSY 2870 SYSFSSSSIG H

Gene Ontology

Classification GO ID Description
Cellular Component GO:0030057 desmosome
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005912 adherens junction
Cellular Component GO:0030424 axon
Cellular Component GO:0016323 basolateral plasma membrane
Cellular Component GO:0030054 cell junction
Cellular Component GO:0001533 cornified envelope
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0005916 fascia adherens
Cellular Component GO:0101003 ficolin-1-rich granule membrane
Cellular Component GO:0014704 intercalated disc
Cellular Component GO:0005882 intermediate filament
Cellular Component GO:0005634 nucleus
Cellular Component GO:0005886 plasma membrane
Molecular Function GO:0086083 cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication
Molecular Function GO:0003677 DNA binding
Molecular Function GO:0005080 protein kinase C binding
Molecular Function GO:0003723 RNA binding
Molecular Function GO:0097110 scaffold protein binding
Molecular Function GO:0005200 structural constituent of cytoskeleton
Molecular Function GO:0005198 structural molecule activity
Biological Process GO:0086073 bundle of His cell-Purkinje myocyte adhesion involved in cell communication
Biological Process GO:0098609 cell-cell adhesion
Biological Process GO:0002934 desmosome organization
Biological Process GO:0008544 epidermis development
Biological Process GO:0090136 epithelial cell-cell adhesion
Biological Process GO:0045104 intermediate filament cytoskeleton organization
Biological Process GO:0045109 intermediate filament organization
Biological Process GO:0030216 keratinocyte differentiation
Biological Process GO:0018149 peptide cross-linking
Biological Process GO:0150105 protein localization to cell-cell junction
Biological Process GO:0086091 regulation of heart rate by cardiac conduction
Biological Process GO:0098911 regulation of ventricular cardiac muscle cell action potential
Biological Process GO:0043588 skin development
Biological Process GO:0003223 ventricular compact myocardium morphogenesis
Biological Process GO:0042060 wound healing

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.

[4] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.

[5] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[6] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[7] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.