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Overview

Uniprot IDP16070
Protein NameCD44 antigen
Gene NameCD44
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
158 DGTRYVQKGEYRTNP
681 RRCGQKKKLVINSGN

Function

Cell-surface receptor that plays a role in cell-cell interactions, cell adhesion and migration, helping them to sense and respond to changes in the tissue microenvironment (PubMed:16541107, PubMed:19703720, PubMed:22726066). Participates thereby in a wide variety of cellular functions including the activation, recirculation and homing of T-lymphocytes, hematopoiesis, inflammation and response to bacterial infection (PubMed:7528188). Engages, through its ectodomain, extracellular matrix components such as hyaluronan/HA, collagen, growth factors, cytokines or proteases and serves as a platform for signal transduction by assembling, via its cytoplasmic domain, protein complexes containing receptor kinases and membrane proteases (PubMed:18757307, PubMed:23589287). Such effectors include PKN2, the RhoGTPases RAC1 and RHOA, Rho-kinases and phospholipase C that coordinate signaling pathways promoting calcium mobilization and actin-mediated cytoskeleton reorganization essential for cell migration and adhesion (PubMed:15123640). Upon interaction with LGALS9 ligand, activates downstream signaling components including LCK, ERK and MAPK to promotes NK cell activation (PubMed:37006235)

Protein Sequence

10 MDKFWWHAAW 20 GLCLVPLSLA 30 QIDLNITCRF 40 AGVFHVEKNG 50 RYSISRTEAA 60 DLCKAFNSTL 70 PTMAQMEKAL 80 SIGFETCRYG 90 FIEGHVVIPR 100 IHPNSICAAN 110 NTGVYILTSN 120 TSQYDTYCFN 130 ASAPPEEDCT 140 SVTDLPNAFD 150 GPITITIVNR 160 DGTRYVQKGE 170 YRTNPEDIYP 180 SNPTDDDVSS 190 GSSSERSSTS 200 GGYIFYTFST 210 VHPIPDEDSP 220 WITDSTDRIP 230 ATTLMSTSAT 240 ATETATKRQE 250 TWDWFSWLFL 260 PSESKNHLHT 270 TTQMAGTSSN 280 TISAGWEPNE 290 ENEDERDRHL 300 SFSGSGIDDD 310 EDFISSTIST 320 TPRAFDHTKQ 330 NQDWTQWNPS 340 HSNPEVLLQT 350 TTRMTDVDRN 360 GTTAYEGNWN 370 PEAHPPLIHH 380 EHHEEEETPH 390 STSTIQATPS 400 STTEETATQK 410 EQWFGNRWHE 420 GYRQTPKEDS 430 HSTTGTAAAS 440 AHTSHPMQGR 450 TTPSPEDSSW 460 TDFFNPISHP 470 MGRGHQAGRR 480 MDMDSSHSIT 490 LQPTANPNTG 500 LVEDLDRTGP 510 LSMTTQQSNS 520 QSFSTSHEGL 530 EEDKDHPTTS 540 TLTSSNRNDV 550 TGGRRDPNHS 560 EGSTTLLEGY 570 TSHYPHTKES 580 RTFIPVTSAK 590 TGSFGVTAVT 600 VGDSNSNVNR 610 SLSGDQDTFH 620 PSGGSHTTHG 630 SESDGHSHGS 640 QEGGANTTSG 650 PIRTPQIPEW 660 LIILASLLAL 670 ALILAVCIAV 680 NSRRRCGQKK 690 KLVINSGNGA 700 VEDRKPSGLN 710 GEASKSQEMV 720 HLVNKESSET 730 PDQFMTADET 740 RNLQNVDMKI GV

Gene Ontology

Classification GO ID Description
Cellular Component GO:0016324 apical plasma membrane
Cellular Component GO:0016323 basolateral plasma membrane
Cellular Component GO:0042995 cell projection
Cellular Component GO:0009986 cell surface
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0005925 focal adhesion
Cellular Component GO:0031258 lamellipodium membrane
Cellular Component GO:0035692 macrophage migration inhibitory factor receptor complex
Cellular Component GO:0045121 membrane raft
Cellular Component GO:0005902 microvillus
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0030667 secretory granule membrane
Molecular Function GO:0038024 cargo receptor activity
Molecular Function GO:0005518 collagen binding
Molecular Function GO:0005540 hyaluronic acid binding
Molecular Function GO:0038023 signaling receptor activity
Molecular Function GO:0004888 transmembrane signaling receptor activity
Biological Process GO:1901264 carbohydrate derivative transport
Biological Process GO:0051216 cartilage development
Biological Process GO:0007155 cell adhesion
Biological Process GO:0016477 cell migration
Biological Process GO:0098609 cell-cell adhesion
Biological Process GO:0007160 cell-matrix adhesion
Biological Process GO:0044344 cellular response to fibroblast growth factor stimulus
Biological Process GO:0019221 cytokine-mediated signaling pathway
Biological Process GO:0006897 endocytosis
Biological Process GO:0030214 hyaluronan catabolic process
Biological Process GO:0006954 inflammatory response
Biological Process GO:0070487 monocyte aggregation
Biological Process GO:0043066 negative regulation of apoptotic process
Biological Process GO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator
Biological Process GO:1902166 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
Biological Process GO:0051132 NK T cell activation
Biological Process GO:0070374 positive regulation of ERK1 and ERK2 cascade
Biological Process GO:0034116 positive regulation of heterotypic cell-cell adhesion
Biological Process GO:1900625 positive regulation of monocyte aggregation
Biological Process GO:2000392 regulation of lamellipodium morphogenesis
Biological Process GO:0042110 T cell activation
Biological Process GO:0044319 wound healing, spreading of cells

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.