Search Results
Overview
| Uniprot ID | P16083 |
|---|---|
| Protein Name | Ribosyldihydronicotinamide dehydrogenase [quinone] |
| Gene Name | NQO2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 5 | ***MAGKKVLIVYAH |
Function
The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis
Protein Sequence
10
MAGKKVLIVY
20
AHQEPKSFNG
30
SLKNVAVDEL
40
SRQGCTVTVS
50
DLYAMNLEPR
60
ATDKDITGTL
70
SNPEVFNYGV
80
ETHEAYKQRS
90
LASDITDEQK
100
KVREADLVIF
110
QFPLYWFSVP
120
AILKGWMDRV
130
LCQGFAFDIP
140
GFYDSGLLQG
150
KLALLSVTTG
160
GTAEMYTKTG
170
VNGDSRYFLW
180
PLQHGTLHFC
190
GFKVLAPQIS
200
FAPEIASEEE
210
RKGMVAAWSQ
220
RLQTIWKEEP
230
IPCTAHWHFG
Q
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0070062 | extracellular exosome |
| Molecular Function | GO:0031404 | chloride ion binding |
| Molecular Function | GO:0001512 | dihydronicotinamide riboside quinone reductase activity |
| Molecular Function | GO:0009055 | electron transfer activity |
| Molecular Function | GO:0071949 | FAD binding |
| Molecular Function | GO:1904408 | melatonin binding |
| Molecular Function | GO:0003955 | NAD(P)H dehydrogenase (quinone) activity |
| Molecular Function | GO:0016491 | oxidoreductase activity |
| Molecular Function | GO:0016661 | oxidoreductase activity, acting on other nitrogenous compounds as donors |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Molecular Function | GO:1905594 | resveratrol binding |
| Molecular Function | GO:0008270 | zinc ion binding |
| Biological Process | GO:1901662 | quinone catabolic process |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.