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Overview

Uniprot IDP16112
Protein NameAggrecan core protein
Gene NameACAN
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
82 WSRVSKEKEVVLLVA

Function

This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region

Protein Sequence

10 MTTLLWVFVT 20 LRVITAAVTV 30 ETSDHDNSLS 40 VSIPQPSPLR 50 VLLGTSLTIP 60 CYFIDPMHPV 70 TTAPSTAPLA 80 PRIKWSRVSK 90 EKEVVLLVAT 100 EGRVRVNSAY 110 QDKVSLPNYP 120 AIPSDATLEV 130 QSLRSNDSGV 140 YRCEVMHGIE 150 DSEATLEVVV 160 KGIVFHYRAI 170 STRYTLDFDR 180 AQRACLQNSA 190 IIATPEQLQA 200 AYEDGFHQCD 210 AGWLADQTVR 220 YPIHTPREGC 230 YGDKDEFPGV 240 RTYGIRDTNE 250 TYDVYCFAEE 260 MEGEVFYATS 270 PEKFTFQEAA 280 NECRRLGARL 290 ATTGQLYLAW 300 QAGMDMCSAG 310 WLADRSVRYP 320 ISKARPNCGG 330 NLLGVRTVYV 340 HANQTGYPDP 350 SSRYDAICYT 360 GEDFVDIPEN 370 FFGVGGEEDI 380 TVQTVTWPDM 390 ELPLPRNITE 400 GEARGSVILT 410 VKPIFEVSPS 420 PLEPEEPFTF 430 APEIGATAFA 440 EVENETGEAT 450 RPWGFPTPGL 460 GPATAFTSED 470 LVVQVTAVPG 480 QPHLPGGVVF 490 HYRPGPTRYS 500 LTFEEAQQAC 510 LRTGAVIASP 520 EQLQAAYEAG 530 YEQCDAGWLR 540 DQTVRYPIVS 550 PRTPCVGDKD 560 SSPGVRTYGV 570 RPSTETYDVY 580 CFVDRLEGEV 590 FFATRLEQFT 600 FQEALEFCES 610 HNATLATTGQ 620 LYAAWSRGLD 630 KCYAGWLADG 640 SLRYPIVTPR 650 PACGGDKPGV 660 RTVYLYPNQT 670 GLPDPLSRHH 680 AFCFRGISAV 690 PSPGEEEGGT 700 PTSPSGVEEW 710 IVTQVVPGVA 720 AVPVEEETTA 730 VPSGETTAIL 740 EFTTEPENQT 750 EWEPAYTPVG 760 TSPLPGILPT 770 WPPTGAATEE 780 STEGPSATEV 790 PSASEEPSPS 800 EVPFPSEEPS 810 PSEEPFPSVR 820 PFPSVELFPS 830 EEPFPSKEPS 840 PSEEPSASEE 850 PYTPSPPVPS 860 WTELPSSGEE 870 SGAPDVSGDF 880 TGSGDVSGHL 890 DFSGQLSGDR 900 ASGLPSGDLD 910 SSGLTSTVGS 920 GLPVESGLPS 930 GDEERIEWPS 940 TPTVGELPSG 950 AEILEGSASG 960 VGDLSGLPSG 970 EVLETSASGV 980 GDLSGLPSGE 990 VLETTAPGVE 1000 DISGLPSGEV 1010 LETTAPGVED 1020 ISGLPSGEVL 1030 ETTAPGVEDI 1040 SGLPSGEVLE 1050 TTAPGVEDIS 1060 GLPSGEVLET 1070 TAPGVEDISG 1080 LPSGEVLETT 1090 APGVEDISGL 1100 PSGEVLETAA 1110 PGVEDISGLP 1120 SGEVLETAAP 1130 GVEDISGLPS 1140 GEVLETAAPG 1150 VEDISGLPSG 1160 EVLETAAPGV 1170 EDISGLPSGE 1180 VLETAAPGVE 1190 DISGLPSGEV 1200 LETAAPGVED 1210 ISGLPSGEVL 1220 ETAAPGVEDI 1230 SGLPSGEVLE 1240 TAAPGVEDIS 1250 GLPSGEVLET 1260 AAPGVEDISG 1270 LPSGEVLETA 1280 APGVEDISGL 1290 PSGEVLETAA 1300 PGVEDISGLP 1310 SGEVLETAAP 1320 GVEDISGLPS 1330 GEVLETAAPG 1340 VEDISGLPSG 1350 EVLETAAPGV 1360 EDISGLPSGE 1370 VLETAAPGVE 1380 DISGLPSGEV 1390 LETAAPGVED 1400 ISGLPSGEVL 1410 ETTAPGVEEI 1420 SGLPSGEVLE 1430 TTAPGVDEIS 1440 GLPSGEVLET 1450 TAPGVEEISG 1460 LPSGEVLETS 1470 TSAVGDLSGL 1480 PSGGEVLEIS 1490 VSGVEDISGL 1500 PSGEVVETSA 1510 SGIEDVSELP 1520 SGEGLETSAS 1530 GVEDLSRLPS 1540 GEEVLEISAS 1550 GFGDLSGLPS 1560 GGEGLETSAS 1570 EVGTDLSGLP 1580 SGREGLETSA 1590 SGAEDLSGLP 1600 SGKEDLVGSA 1610 SGDLDLGKLP 1620 SGTLGSGQAP 1630 ETSGLPSGFS 1640 GEYSGVDLGS 1650 GPPSGLPDFS 1660 GLPSGFPTVS 1670 LVDSTLVEVV 1680 TASTASELEG 1690 RGTIGISGAG 1700 EISGLPSSEL 1710 DISGRASGLP 1720 SGTELSGQAS 1730 GSPDVSGEIP 1740 GLFGVSGQPS 1750 GFPDTSGETS 1760 GVTELSGLSS 1770 GQPGISGEAS 1780 GVLYGTSQPF 1790 GITDLSGETS 1800 GVPDLSGQPS 1810 GLPGFSGATS 1820 GVPDLVSGTT 1830 SGSGESSGIT 1840 FVDTSLVEVA 1850 PTTFKEEEGL 1860 GSVELSGLPS 1870 GEADLSGKSG 1880 MVDVSGQFSG 1890 TVDSSGFTSQ 1900 TPEFSGLPSG 1910 IAEVSGESSR 1920 AEIGSSLPSG 1930 AYYGSGTPSS 1940 FPTVSLVDRT 1950 LVESVTQAPT 1960 AQEAGEGPSG 1970 ILELSGAHSG 1980 APDMSGEHSG 1990 FLDLSGLQSG 2000 LIEPSGEPPG 2010 TPYFSGDFAS 2020 TTNVSGESSV 2030 AMGTSGEASG 2040 LPEVTLITSE 2050 FVEGVTEPTI 2060 SQELGQRPPV 2070 THTPQLFESS 2080 GKVSTAGDIS 2090 GATPVLPGSG 2100 VEVSSVPESS 2110 SETSAYPEAG 2120 FGASAAPEAS 2130 REDSGSPDLS 2140 ETTSAFHEAN 2150 LERSSGLGVS 2160 GSTLTFQEGE 2170 ASAAPEVSGE 2180 STTTSDVGTE 2190 APGLPSATPT 2200 ASGDRTEISG 2210 DLSGHTSQLG 2220 VVISTSIPES 2230 EWTQQTQRPA 2240 ETHLEIESSS 2250 LLYSGEETHT 2260 VETATSPTDA 2270 SIPASPEWKR 2280 ESESTAAAPA 2290 RSCAEEPCGA 2300 GTCKETEGHV 2310 ICLCPPGYTG 2320 EHCNIDQEVC 2330 EEGWNKYQGH 2340 CYRHFPDRET 2350 WVDAERRCRE 2360 QQSHLSSIVT 2370 PEEQEFVNNN 2380 AQDYQWIGLN 2390 DRTIEGDFRW 2400 SDGHPMQFEN 2410 WRPNQPDNFF 2420 AAGEDCVVMI 2430 WHEKGEWNDV 2440 PCNYHLPFTC 2450 KKGTVACGEP 2460 PVVEHARTFG 2470 QKKDRYEINS 2480 LVRYQCTEGF 2490 VQRHMPTIRC 2500 QPSGHWEEPQ 2510 ITCTDPTTYK 2520 RRLQKRSSRH 2530 PRRSRPSTAH

Gene Ontology

Classification GO ID Description
Cellular Component GO:0031012 extracellular matrix
Cellular Component GO:0005576 extracellular region
Cellular Component GO:0005615 extracellular space
Cellular Component GO:0140150 gel phase of interstitial matrix
Cellular Component GO:0005796 Golgi lumen
Cellular Component GO:0043202 lysosomal lumen
Cellular Component GO:0072534 perineuronal net
Cellular Component GO:0045202 synapse
Molecular Function GO:0030246 carbohydrate binding
Molecular Function GO:0005201 extracellular matrix structural constituent
Molecular Function GO:0005540 hyaluronic acid binding
Molecular Function GO:0046872 metal ion binding
Biological Process GO:0007155 cell adhesion
Biological Process GO:0007417 central nervous system development
Biological Process GO:0006508 proteolysis
Biological Process GO:0001501 skeletal system development

Reference

[1] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.