Search Results
Overview
| Uniprot ID | P16118 |
|---|---|
| Protein Name | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 |
| Gene Name | PFKFB1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 175 | AENIRQVKLGSPDYI |
Function
Synthesis and degradation of fructose 2,6-bisphosphate
Protein Sequence
10
MSPEMGELTQ
20
TRLQKIWIPH
30
SSGSSRLQRR
40
RGSSIPQFTN
50
SPTMVIMVGL
60
PARGKTYIST
70
KLTRYLNWIG
80
TPTKVFNLGQ
90
YRREAVSYKN
100
YEFFLPDNME
110
ALQIRKQCAL
120
AALKDVHNYL
130
SHEEGHVAVF
140
DATNTTRERR
150
SLILQFAKEH
160
GYKVFFIESI
170
CNDPGIIAEN
180
IRQVKLGSPD
190
YIDCDREKVL
200
EDFLKRIECY
210
EVNYQPLDEE
220
LDSHLSYIKI
230
FDVGTRYMVN
240
RVQDHIQSRT
250
VYYLMNIHVT
260
PRSIYLCRHG
270
ESELNIRGRI
280
GGDSGLSVRG
290
KQYAYALANF
300
IQSQGISSLK
310
VWTSHMKRTI
320
QTAEALGVPY
330
EQWKALNEID
340
AGVCEEMTYE
350
EIQEHYPEEF
360
ALRDQDKYRY
370
RYPKGESYED
380
LVQRLEPVIM
390
ELERQENVLV
400
ICHQAVMRCL
410
LAYFLDKSSD
420
ELPYLKCPLH
430
TVLKLTPVAY
440
GCKVESIYLN
450
VEAVNTHREK
460
PENVDITREP
470
EEALDTVPAH
Y
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0043540 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex |
| Cellular Component | GO:0005829 | cytosol |
| Molecular Function | GO:0003873 | 6-phosphofructo-2-kinase activity |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0004331 | fructose-2,6-bisphosphate 2-phosphatase activity |
| Molecular Function | GO:0042802 | identical protein binding |
| Biological Process | GO:0006003 | fructose 2,6-bisphosphate metabolic process |
| Biological Process | GO:0006000 | fructose metabolic process |
| Biological Process | GO:0006094 | gluconeogenesis |
| Biological Process | GO:0006096 | glycolytic process |
| Biological Process | GO:1904539 | negative regulation of glycolytic process through fructose-6-phosphate |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.