Search Results

Overview

Uniprot ID	P16219
Protein Name	Short-chain specific acyl-CoA dehydrogenase, mitochondrial
Gene Name	ACADS
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
133	PILKFGSKEQKQAWV
335	TWRAAMLKDNKKPFI
72	LFPAAQVKKMGGLGL

Function

Short-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats (By similarity). The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA (By similarity). Among the different mitochondrial acyl-CoA dehydrogenases, short-chain specific acyl-CoA dehydrogenase acts specifically on acyl-CoAs with saturated 4 to 6 carbons long primary chains (PubMed:11134486, PubMed:21237683)

Protein Sequence

10 MAAALLARAS 20 GPARRALCPR 30 AWRQLHTIYQ 40 SVELPETHQM 50 LLQTCRDFAE 60 KELFPIAAQV 70 DKEHLFPAAQ 80 VKKMGGLGLL 90 AMDVPEELGG 100 AGLDYLAYAI 110 AMEEISRGCA 120 STGVIMSVNN 130 SLYLGPILKF 140 GSKEQKQAWV 150 TPFTSGDKIG 160 CFALSEPGNG 170 SDAGAASTTA 180 RAEGDSWVLN 190 GTKAWITNAW 200 EASAAVVFAS 210 TDRALQNKGI 220 SAFLVPMPTP 230 GLTLGKKEDK 240 LGIRGSSTAN 250 LIFEDCRIPK 260 DSILGEPGMG 270 FKIAMQTLDM 280 GRIGIASQAL 290 GIAQTALDCA 300 VNYAENRMAF 310 GAPLTKLQVI 320 QFKLADMALA 330 LESARLLTWR 340 AAMLKDNKKP 350 FIKEAAMAKL 360 AASEAATAIS 370 HQAIQILGGM 380 GYVTEMPAER 390 HYRDARITEI 400 YEGTSEIQRL 410 VIAGHLLRSY RS

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005759	mitochondrial matrix
Cellular Component	GO:0005739	mitochondrion
Cellular Component	GO:0005634	nucleus
Molecular Function	GO:0003995	acyl-CoA dehydrogenase activity
Molecular Function	GO:0050660	flavin adenine dinucleotide binding
Molecular Function	GO:0016937	short-chain fatty acyl-CoA dehydrogenase activity
Biological Process	GO:0046359	butyrate catabolic process
Biological Process	GO:0006635	fatty acid beta-oxidation
Biological Process	GO:0033539	fatty acid beta-oxidation using acyl-CoA dehydrogenase

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.