Search Results
Overview
| Uniprot ID | P16220 |
|---|---|
| Protein Name | Cyclic AMP-responsive element-binding protein 1 |
| Gene Name | CREB1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 122 | SRRPSYRKILNDLSS |
| 295 | RKKKEYVKCLENRVA |
Function
Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters (By similarity). Transcription activation is enhanced by the TORC coactivators which act independently of Ser-119 phosphorylation (PubMed:14536081). Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells (By similarity). Regulates the expression of apoptotic and inflammatory response factors in cardiomyocytes in response to ERFE-mediated activation of AKT signaling (By similarity)
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0000785 | chromatin |
| Cellular Component | GO:1990589 | ATF4-CREB1 transcription factor complex |
| Cellular Component | GO:0030424 | axon |
| Cellular Component | GO:0000791 | euchromatin |
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:1990763 | arrestin family protein binding |
| Molecular Function | GO:0035497 | cAMP response element binding |
| Molecular Function | GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific |
| Molecular Function | GO:0003700 | DNA-binding transcription factor activity |
| Molecular Function | GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific |
| Molecular Function | GO:0019899 | enzyme binding |
| Molecular Function | GO:0035035 | histone acetyltransferase binding |
| Molecular Function | GO:0030544 | Hsp70 protein binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| Molecular Function | GO:0061629 | RNA polymerase II-specific DNA-binding transcription factor binding |
| Molecular Function | GO:1990837 | sequence-specific double-stranded DNA binding |
| Molecular Function | GO:0001223 | transcription coactivator binding |
| Biological Process | GO:0141156 | cAMP/PKA signal transduction |
| Biological Process | GO:0030154 | cell differentiation |
| Biological Process | GO:0071398 | cellular response to fatty acid |
| Biological Process | GO:1904322 | cellular response to forskolin |
| Biological Process | GO:1990314 | cellular response to insulin-like growth factor stimulus |
| Biological Process | GO:1990090 | cellular response to nerve growth factor stimulus |
| Biological Process | GO:0036120 | cellular response to platelet-derived growth factor stimulus |
| Biological Process | GO:0071300 | cellular response to retinoic acid |
| Biological Process | GO:0034670 | chemotaxis to arachidonate |
| Biological Process | GO:0007623 | circadian rhythm |
| Biological Process | GO:0007613 | memory |
| Biological Process | GO:0042789 | mRNA transcription by RNA polymerase II |
| Biological Process | GO:0043066 | negative regulation of apoptotic process |
| Biological Process | GO:0010629 | negative regulation of gene expression |
| Biological Process | GO:0010944 | negative regulation of transcription by competitive promoter binding |
| Biological Process | GO:0043065 | positive regulation of apoptotic process |
| Biological Process | GO:0045893 | positive regulation of DNA-templated transcription |
| Biological Process | GO:0045600 | positive regulation of fat cell differentiation |
| Biological Process | GO:0046889 | positive regulation of lipid biosynthetic process |
| Biological Process | GO:1900273 | positive regulation of long-term synaptic potentiation |
| Biological Process | GO:1904181 | positive regulation of membrane depolarization |
| Biological Process | GO:0045899 | positive regulation of RNA polymerase II transcription preinitiation complex assembly |
| Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| Biological Process | GO:0032916 | positive regulation of transforming growth factor beta3 production |
| Biological Process | GO:0006468 | protein phosphorylation |
| Biological Process | GO:0050821 | protein stabilization |
| Biological Process | GO:0048145 | regulation of fibroblast proliferation |
| Biological Process | GO:0060251 | regulation of glial cell proliferation |
| Biological Process | GO:2000224 | regulation of testosterone biosynthetic process |
| Biological Process | GO:0006357 | regulation of transcription by RNA polymerase II |
| Biological Process | GO:0014823 | response to activity |
| Biological Process | GO:0042220 | response to cocaine |
| Biological Process | GO:1903494 | response to dehydroepiandrosterone |
| Biological Process | GO:0036017 | response to erythropoietin |
| Biological Process | GO:0045471 | response to ethanol |
| Biological Process | GO:0033762 | response to glucagon |
| Biological Process | GO:1990910 | response to hypobaric hypoxia |
| Biological Process | GO:1902065 | response to L-glutamate |
| Biological Process | GO:0043278 | response to morphine |
| Biological Process | GO:0035094 | response to nicotine |
| Biological Process | GO:0014074 | response to purine-containing compound |
| Biological Process | GO:0009410 | response to xenobiotic stimulus |
| Biological Process | GO:0007165 | signal transduction |
| Biological Process | GO:0007179 | transforming growth factor beta receptor signaling pathway |
| Biological Process | GO:0008542 | visual learning |
Reference
[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.
[2] Yang YH, Wang QC, Kong J, Yang JT, Liu JF. Global profiling of lysine lactylation in human lungs.. Proteomics 23(15):e2200437. 2023 Aug. PMID: 37170646.
[3] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.
[4] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.
[5] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.
[6] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.