Search Results

Overview

Uniprot IDP16276
Protein NameAconitate hydratase, mitochondrial
Gene NameACO2
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
228 PWELKCPKVIGVKLT
401 GRSAAVAKQALAHGL
517 ETDFLTGKDGKKFKL
549 DTYQHPPKDSSGQRV
591 ILIKVKGKCTTDHIS
605 SAAGPWLKFRGHLDN
651 PDTARYYKQHGIRWV
723 NKIHPVDKLTIQGLK
730 KLTIQGLKDFAPGKP
736 LKDFAPGKPLKCIIK

Function

Catalyzes the isomerization of citrate to isocitrate via cis-aconitate

Protein Sequence

10 MAPYSLLVTR 20 LQKALGVRQY 30 HVASVLCQRA 40 KVAMSHFEPH 50 EYIRYDLLEK 60 NIDIVRKRLN 70 RPLTLSEKIV 80 YGHLDDPANQ 90 EIERGKTYLR 100 LRPDRVAMQD 110 ATAQMAMLQF 120 ISSGLPKVAV 130 PSTIHCDHLI 140 EAQLGGEKDL 150 RRAKDINQEV 160 YNFLATAGAK 170 YGVGFWRPGS 180 GIIHQIILEN 190 YAYPGVLLIG 200 TDSHTPNGGG 210 LGGICIGVGG 220 ADAVDVMAGI 230 PWELKCPKVI 240 GVKLTGSLSG 250 WTSPKDVILK 260 VAGILTVKGG 270 TGAIVEYHGP 280 GVDSISCTGM 290 ATICNMGAEI 300 GATTSVFPYN 310 HRMKKYLSKT 320 GRADIANLAD 330 EFKDHLVPDP 340 GCHYDQVIEI 350 NLSELKPHIN 360 GPFTPDLAHP 370 VAEVGSVAEK 380 EGWPLDIRVG 390 LIGSCTNSSY 400 EDMGRSAAVA 410 KQALAHGLKC 420 KSQFTITPGS 430 EQIRATIERD 440 GYAQVLRDVG 450 GIVLANACGP 460 CIGQWDRKDI 470 KKGEKNTIVT 480 SYNRNFTGRN 490 DANPETHAFV 500 TSPEIVTALA 510 IAGTLKFNPE 520 TDFLTGKDGK 530 KFKLEAPDAD 540 ELPRAEFDPG 550 QDTYQHPPKD 560 SSGQRVDVSP 570 TSQRLQLLEP 580 FDKWDGKDLE 590 DLQILIKVKG 600 KCTTDHISAA 610 GPWLKFRGHL 620 DNISNNLLIG 630 AINIENRKAN 640 SVRNAVTQEF 650 GPVPDTARYY 660 KQHGIRWVVI 670 GDENYGEGSS 680 REHRALEPRH 690 LGGRAIITKS 700 FARIHETNLK 710 KQGLLPLTFA 720 DPADYNKIHP 730 VDKLTIQGLK 740 DFAPGKPLKC 750 IIKHPNGTQE 760 TILLNHTFNE 770 TQIEWFRAGS 780 ALNRMKELQQ K

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005739 mitochondrion
Molecular Function GO:0051539 4 iron, 4 sulfur cluster binding
Molecular Function GO:0003994 aconitate hydratase activity
Molecular Function GO:0046872 metal ion binding
Biological Process GO:0006099 tricarboxylic acid cycle

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.