Search Results
Overview
| Uniprot ID | P16278 |
|---|---|
| Protein Name | Beta-galactosidase |
| Gene Name | GLB1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 43 | YSRDSFLKDGQPFRY |
Function
Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans
Protein Sequence
10
MPGFLVRILP
20
LLLVLLLLGP
30
TRGLRNATQR
40
MFEIDYSRDS
50
FLKDGQPFRY
60
ISGSIHYSRV
70
PRFYWKDRLL
80
KMKMAGLNAI
90
QTYVPWNFHE
100
PWPGQYQFSE
110
DHDVEYFLRL
120
AHELGLLVIL
130
RPGPYICAEW
140
EMGGLPAWLL
150
EKESILLRSS
160
DPDYLAAVDK
170
WLGVLLPKMK
180
PLLYQNGGPV
190
ITVQVENEYG
200
SYFACDFDYL
210
RFLQKRFRHH
220
LGDDVVLFTT
230
DGAHKTFLKC
240
GALQGLYTTV
250
DFGTGSNITD
260
AFLSQRKCEP
270
KGPLINSEFY
280
TGWLDHWGQP
290
HSTIKTEAVA
300
SSLYDILARG
310
ASVNLYMFIG
320
GTNFAYWNGA
330
NSPYAAQPTS
340
YDYDAPLSEA
350
GDLTEKYFAL
360
RNIIQKFEKV
370
PEGPIPPSTP
380
KFAYGKVTLE
390
KLKTVGAALD
400
ILCPSGPIKS
410
LYPLTFIQVK
420
QHYGFVLYRT
430
TLPQDCSNPA
440
PLSSPLNGVH
450
DRAYVAVDGI
460
PQGVLERNNV
470
ITLNITGKAG
480
ATLDLLVENM
490
GRVNYGAYIN
500
DFKGLVSNLT
510
LSSNILTDWT
520
IFPLDTEDAV
530
RSHLGGWGHR
540
DSGHHDEAWA
550
HNSSNYTLPA
560
FYMGNFSIPS
570
GIPDLPQDTF
580
IQFPGWTKGQ
590
VWINGFNLGR
600
YWPARGPQLT
610
LFVPQHILMT
620
SAPNTITVLE
630
LEWAPCSSDD
640
PELCAVTFVD
650
RPVIGSSVTY
660
DHPSKPVEKR
670
LMPPPPQKNK
DSWLDHV
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0035578 | azurophil granule lumen |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0005576 | extracellular region |
| Cellular Component | GO:1904813 | ficolin-1-rich granule lumen |
| Cellular Component | GO:0043202 | lysosomal lumen |
| Cellular Component | GO:0005764 | lysosome |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| Cellular Component | GO:0005773 | vacuole |
| Molecular Function | GO:0004565 | beta-galactosidase activity |
| Molecular Function | GO:0016936 | galactoside binding |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Biological Process | GO:0005975 | carbohydrate metabolic process |
| Biological Process | GO:0019388 | galactose catabolic process |
| Biological Process | GO:0006689 | ganglioside catabolic process |
| Biological Process | GO:0006516 | glycoprotein catabolic process |
| Biological Process | GO:0042340 | keratan sulfate proteoglycan catabolic process |
| Biological Process | GO:0051413 | response to cortisone |
| Biological Process | GO:1904016 | response to Thyroglobulin triiodothyronine |
Reference
[1] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.