Overview
| Uniprot ID | P16298 |
|---|
| Protein Name | Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform |
|---|
| Gene Name | PPP3CB |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 56 |
IPRVDVLKNHLVKEG |
Function
Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals (PubMed:19154138, PubMed:25720963, PubMed:26794871, PubMed:32753672). Dephosphorylates TFEB in response to lysosomal Ca(2+) release, resulting in TFEB nuclear translocation and stimulation of lysosomal biogenesis (PubMed:25720963, PubMed:32753672). Dephosphorylates and activates transcription factor NFATC1 (PubMed:19154138). Dephosphorylates and inactivates transcription factor ELK1 (PubMed:19154138). Dephosphorylates DARPP32 (PubMed:19154138). Negatively regulates MAP3K14/NIK signaling via inhibition of nuclear translocation of the transcription factors RELA and RELB (By similarity). May play a role in skeletal muscle fiber type specification (By similarity)
Protein Sequence
10
MAAPEPARAA
20
PPPPPPPPPP
30
PGADRVVKAV
40
PFPPTHRLTS
50
EEVFDLDGIP
60
RVDVLKNHLV
70
KEGRVDEEIA
80
LRIINEGAAI
90
LRREKTMIEV
100
EAPITVCGDI
110
HGQFFDLMKL
120
FEVGGSPANT
130
RYLFLGDYVD
140
RGYFSIECVL
150
YLWVLKILYP
160
STLFLLRGNH
170
ECRHLTEYFT
180
FKQECKIKYS
190
ERVYEACMEA
200
FDSLPLAALL
210
NQQFLCVHGG
220
LSPEIHTLDD
230
IRRLDRFKEP
240
PAFGPMCDLL
250
WSDPSEDFGN
260
EKSQEHFSHN
270
TVRGCSYFYN
280
YPAVCEFLQN
290
NNLLSIIRAH
300
EAQDAGYRMY
310
RKSQTTGFPS
320
LITIFSAPNY
330
LDVYNNKAAV
340
LKYENNVMNI
350
RQFNCSPHPY
360
WLPNFMDVFT
370
WSLPFVGEKV
380
TEMLVNVLSI
390
CSDDELMTEG
400
EDQFDGSAAA
410
RKEIIRNKIR
420
AIGKMARVFS
430
VLREESESVL
440
TLKGLTPTGM
450
LPSGVLAGGR
460
QTLQSATVEA
470
IEAEKAIRGF
480
SPPHRICSFE
490
EAKGLDRINE
500
RMPPRKDAVQ
510
QDGFNSLNTA
520
HATENHGTGN
HTAQ
Gene Ontology
| Classification |
GO ID |
Description |
| Molecular Function |
GO:0033192 |
calmodulin-dependent protein phosphatase activity |
| Cellular Component |
GO:0005955 |
calcineurin complex |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0098978 |
glutamatergic synapse |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Cellular Component |
GO:0030315 |
T-tubule |
| Cellular Component |
GO:0030018 |
Z disc |
| Molecular Function |
GO:0005509 |
calcium ion binding |
| Molecular Function |
GO:0005516 |
calmodulin binding |
| Molecular Function |
GO:0019899 |
enzyme binding |
| Molecular Function |
GO:0046983 |
protein dimerization activity |
| Molecular Function |
GO:0030346 |
protein phosphatase 2B binding |
| Molecular Function |
GO:0004722 |
protein serine/threonine phosphatase activity |
| Biological Process |
GO:0048675 |
axon extension |
| Biological Process |
GO:0097720 |
calcineurin-mediated signaling |
| Biological Process |
GO:0033173 |
calcineurin-NFAT signaling cascade |
| Biological Process |
GO:0017156 |
calcium-ion regulated exocytosis |
| Biological Process |
GO:0016311 |
dephosphorylation |
| Biological Process |
GO:0007612 |
learning |
| Biological Process |
GO:0007613 |
memory |
| Biological Process |
GO:1905949 |
negative regulation of calcium ion import across plasma membrane |
| Biological Process |
GO:0023057 |
negative regulation of signaling |
| Biological Process |
GO:0070886 |
positive regulation of calcineurin-NFAT signaling cascade |
| Biological Process |
GO:1905665 |
positive regulation of calcium ion import across plasma membrane |
| Biological Process |
GO:0045893 |
positive regulation of DNA-templated transcription |
| Biological Process |
GO:0035774 |
positive regulation of insulin secretion involved in cellular response to glucose stimulus |
| Biological Process |
GO:1905673 |
positive regulation of lysosome organization |
| Biological Process |
GO:1900182 |
positive regulation of protein localization to nucleus |
| Biological Process |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
| Biological Process |
GO:0006470 |
protein dephosphorylation |
| Biological Process |
GO:0006468 |
protein phosphorylation |
| Biological Process |
GO:0050796 |
regulation of insulin secretion |
| Biological Process |
GO:0048167 |
regulation of synaptic plasticity |
| Biological Process |
GO:1900242 |
regulation of synaptic vesicle endocytosis |
| Biological Process |
GO:0007165 |
signal transduction |
| Biological Process |
GO:0048741 |
skeletal muscle fiber development |
| Biological Process |
GO:0042110 |
T cell activation |
| Biological Process |
GO:0042098 |
T cell proliferation |
Reference
[1] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.