Search Results

Overview

Uniprot ID	P16330
Protein Name	2',3'-cyclic-nucleotide 3'-phosphodiesterase
Gene Name	Cnp
Organism	Mus musculus

Kla Sites from experimental identification

Position	Flanking peptide
177	ADDLKKLKPGLEKDF

Function

Myelin-associated enzyme that catalyzes the phosphodiester hydrolysis of 2',3'-cyclic nucleotides to 2'-nucleotides (PubMed:22393399). In the mitochondria, regulates the functioning of the mitochondrial permeability transition pore (mPTP), and thus is involved in the mechanisms of cell death, both apoptosis and necrosis. Acts as an antiviral factor by suppressing the assembly of SARS-CoV-2 virions

Protein Sequence

10 MNTSFTRKSH 20 TFLPKLFFRK 30 MSSSGAKEKP 40 ELQFPFLQDE 50 DTVATLHECK 60 TLFILRGLPG 70 SGKSTLARLI 80 LEKYHDGTKM 90 VSADAYKIIP 100 GSRADFSEAY 110 KRLDEDLAGY 120 CRRDIRVLVL 130 DDTNHERERL 140 DQLFEMADQY 150 QYQVVLVEPK 160 TAWRLDCAQL 170 KEKNQWQLSA 180 DDLKKLKPGL 190 EKDFLPLYFG 200 WFLTKKSSET 210 LRKAGQVFLE 220 ELGNHKAFKK 230 ELRHFISGDE 240 PKEKLELVSY 250 FGKRPPGVLH 260 CTTKFCDYGK 270 AAGAEEYAQQ 280 EVVKRSYGKA 290 FKLSISALFV 300 TPKTAGAQVV 310 LTDQELQLWP 320 SDLDKPSASE 330 GLPPGSRAHV 340 TLGCAADVQP 350 VQTGLDLLDI 360 LQQVKGGSQG 370 EAVGELPRGK 380 LYSLGKGRWM 390 LSLTKKMEVK 400 AIFTGYYGKG 410 KPVPIHGSRK 420 GGAMQICTII

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0042995	cell projection
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005615	extracellular space
Cellular Component	GO:0042470	melanosome
Cellular Component	GO:0016020	membrane
Cellular Component	GO:0005874	microtubule
Cellular Component	GO:0005902	microvillus
Cellular Component	GO:0005743	mitochondrial inner membrane
Cellular Component	GO:0005741	mitochondrial outer membrane
Cellular Component	GO:0043209	myelin sheath
Cellular Component	GO:0035748	myelin sheath abaxonal region
Cellular Component	GO:0035749	myelin sheath adaxonal region
Cellular Component	GO:0048471	perinuclear region of cytoplasm
Cellular Component	GO:0031143	pseudopodium
Molecular Function	GO:0004113	2',3'-cyclic-nucleotide 3'-phosphodiesterase activity
Molecular Function	GO:0030551	cyclic nucleotide binding
Molecular Function	GO:0003723	RNA binding
Biological Process	GO:0008344	adult locomotory behavior
Biological Process	GO:0007409	axonogenesis
Biological Process	GO:0009214	cyclic nucleotide catabolic process
Biological Process	GO:0048709	oligodendrocyte differentiation
Biological Process	GO:0046902	regulation of mitochondrial membrane permeability
Biological Process	GO:0009636	response to toxic substance

Reference

[1] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.

[2] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.