Search Results
Overview
| Uniprot ID | P16332 |
|---|---|
| Protein Name | Methylmalonyl-CoA mutase, mitochondrial |
| Gene Name | Mmut |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 210 | EQGVPKEKLTGTIQN |
| 593 | RQEFGESKEITSAIK |
| 600 | KEITSAIKRVNKFME |
| 604 | SAIKRVNKFMEREGR |
Function
Catalyzes the reversible isomerization of methylmalonyl-CoA (MMCoA) (generated from branched-chain amino acid metabolism and degradation of dietary odd chain fatty acids and cholesterol) to succinyl-CoA (3-carboxypropionyl-CoA), a key intermediate of the tricarboxylic acid cycle
Protein Sequence
10
MLRAKNQLFL
20
LSPHYLKQLN
30
IPSASRWKRL
40
LHQQQPLHPE
50
WAVLAKKQLK
60
GKNPEDLIWH
70
TPEGISIKPL
80
YSRADTLDLP
90
EELPGVKPFT
100
RGPYPTMYTY
110
RPWTIRQYAG
120
FSTVEESNKF
130
YKDNIKAGQQ
140
GLSVAFDLAT
150
HRGYDSDNPR
160
VRGDVGMAGV
170
AIDTVEDTKI
180
LFDGIPLEKM
190
SVSMTMNGAV
200
IPVLATFIVT
210
GEEQGVPKEK
220
LTGTIQNDIL
230
KEFMVRNTYI
240
FPPEPSMKII
250
ADIFQYTAQH
260
MPKFNSISIS
270
GYHMQEAGAD
280
AILELAYTIA
290
DGLEYCRTGL
300
QAGLTIDEFA
310
PRLSFFWGIG
320
MNFYMEIAKM
330
RAGRRLWAHL
340
IEKMFQPKNS
350
KSLLLRAHCQ
360
TSGWSLTEQD
370
PYNNIVRTAI
380
EAMAAVFGGT
390
QSLHTNSFDE
400
ALGLPTVKSA
410
RIARNTQIII
420
QEESGIPKVA
430
DPWGGSYMME
440
SLTNDVYEAA
450
LKLIYEVEEM
460
GGMAKAVAEG
470
IPKLRIEECA
480
ARRQARIDSG
490
SEVIVGVNKY
500
QLEKEDSVEV
510
LAIDNTSVRK
520
KQIEKLKKIK
530
SSRDQALAEQ
540
CLSALTQCAA
550
SGDGNILALA
560
VDAARARCTV
570
GEITDALKKV
580
FGEHKANDRM
590
VSGAYRQEFG
600
ESKEITSAIK
610
RVNKFMEREG
620
RRPRLLVAKM
630
GQDGHDRGAK
640
VIATGFADLG
650
FDVDIGPLFQ
660
TPREVAQQAV
670
DADVHAVGVS
680
TLAAGHKTLV
690
PELIKELTAL
700
GRPDILVMCG
710
GVIPPQDYEF
720
LYEVGVSNVF
730
GPGTRIPRAA
740
VQVLDDIEKC
LAEKQQSV
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0031419 | cobalamin binding |
| Molecular Function | GO:0003924 | GTPase activity |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0004494 | methylmalonyl-CoA mutase activity |
| Molecular Function | GO:0072341 | modified amino acid binding |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Biological Process | GO:0050667 | homocysteine metabolic process |
| Biological Process | GO:0043547 | positive regulation of GTPase activity |
| Biological Process | GO:0009791 | post-embryonic development |
| Biological Process | GO:0019678 | propionate metabolic process, methylmalonyl pathway |
| Biological Process | GO:1901290 | succinyl-CoA biosynthetic process |
Reference
[1] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.
[2] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.