Search Results
Overview
| Uniprot ID | P16333 |
|---|---|
| Protein Name | SH2/SH3 adapter protein NCK1 |
| Gene Name | NCK1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 69 | ARKASIVKNLKDTLG |
| 72 | ASIVKNLKDTLGIGK |
| 79 | KDTLGIGKVKRKPSV |
| 81 | TLGIGKVKRKPSVPD |
Function
Adapter protein which associates with tyrosine-phosphorylated growth factor receptors, such as KDR and PDGFRB, or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in the DNA damage response, not in the detection of the damage by ATM/ATR, but for efficient activation of downstream effectors, such as that of CHEK2. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling. Modulates the activation of EIF2AK2/PKR by dsRNA. May play a role in cell adhesion and migration through interaction with ephrin receptors
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005911 | cell-cell junction |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0000164 | protein phosphatase type 1 complex |
| Cellular Component | GO:0005840 | ribosome |
| Cellular Component | GO:0012506 | vesicle membrane |
| Molecular Function | GO:0045296 | cadherin binding |
| Molecular Function | GO:0008093 | cytoskeletal anchor activity |
| Molecular Function | GO:0046875 | ephrin receptor binding |
| Molecular Function | GO:0071074 | eukaryotic initiation factor eIF2 binding |
| Molecular Function | GO:0140693 | molecular condensate scaffold activity |
| Molecular Function | GO:0019904 | protein domain specific binding |
| Molecular Function | GO:0004860 | protein kinase inhibitor activity |
| Molecular Function | GO:0140311 | protein sequestering activity |
| Molecular Function | GO:0030674 | protein-macromolecule adaptor activity |
| Molecular Function | GO:0030971 | receptor tyrosine kinase binding |
| Molecular Function | GO:0035591 | signaling adaptor activity |
| Molecular Function | GO:0005102 | signaling receptor binding |
| Molecular Function | GO:0030159 | signaling receptor complex adaptor activity |
| Biological Process | GO:0140374 | antiviral innate immune response |
| Biological Process | GO:0016477 | cell migration |
| Biological Process | GO:0048013 | ephrin receptor signaling pathway |
| Biological Process | GO:0046627 | negative regulation of insulin receptor signaling pathway |
| Biological Process | GO:1903898 | negative regulation of PERK-mediated unfolded protein response |
| Biological Process | GO:0050860 | negative regulation of T cell receptor signaling pathway |
| Biological Process | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| Biological Process | GO:0030838 | positive regulation of actin filament polymerization |
| Biological Process | GO:1903676 | positive regulation of cap-dependent translational initiation |
| Biological Process | GO:1903679 | positive regulation of cap-independent translational initiation |
| Biological Process | GO:1902237 | positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway |
| Biological Process | GO:0042102 | positive regulation of T cell proliferation |
| Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| Biological Process | GO:0036493 | positive regulation of translation in response to endoplasmic reticulum stress |
| Biological Process | GO:0036491 | regulation of translation initiation in response to endoplasmic reticulum stress |
| Biological Process | GO:0034976 | response to endoplasmic reticulum stress |
| Biological Process | GO:0007172 | signal complex assembly |
| Biological Process | GO:0042110 | T cell activation |
Reference
[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.
[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.