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Overview

Uniprot IDP16383
Protein NameIntron Large complex component GCFC2
Gene NameGCFC2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
236 QQMRKAVKIIEERDI
295 SHLREYEKYVQDVKS
304 VQDVKSSKSTIQNLE
79 ASSRRATKAAPRADE

Function

Involved in pre-mRNA splicing through regulating spliceosome C complex formation (PubMed:24304693). May play a role during late-stage splicing events and turnover of excised introns (PubMed:24304693)

Protein Sequence

10 MAHRPKRTFR 20 QRAADSSDSD 30 GAEESPAEPG 40 APRELPVPGS 50 AEEEPPSGGG 60 RAQVAGLPHR 70 VRGPRGRGRV 80 WASSRRATKA 90 APRADEGSES 100 RTLDVSTDEE 110 DKIHHSSESK 120 DDQGLSSDSS 130 SSLGEKELSS 140 TVKIPDAAFI 150 QAARRKRELA 160 RAQDDYISLD 170 VQHTSSISGM 180 KRESEDDPES 190 EPDDHEKRIP 200 FTLRPQTLRQ 210 RMAEESISRN 220 EETSEESQED 230 EKQDTWEQQQ 240 MRKAVKIIEE 250 RDIDLSCGNG 260 SSKVKKFDTS 270 ISFPPVNLEI 280 IKKQLNTRLT 290 LLQETHRSHL 300 REYEKYVQDV 310 KSSKSTIQNL 320 ESSSNQALNC 330 KFYKSMKIYV 340 ENLIDCLNEK 350 IINIQEIESS 360 MHALLLKQAM 370 TFMKRRQDEL 380 KHESTYLQQL 390 SRKDETSTSG 400 NFSVDEKTQW 410 ILEEIESRRT 420 KRRQARVLSG 430 NCNHQEGTSS 440 DDELPSAEMI 450 DFQKSQGDIL 460 QKQKKVFEEV 470 QDDFCNIQNI 480 LLKFQQWREK 490 FPDSYYEAFI 500 SLCIPKLLNP 510 LIRVQLIDWN 520 PLKLESTGLK 530 EMPWFKSVEE 540 FMDSSVEDSK 550 KESSSDKKVL 560 SAIINKTIIP 570 RLTDFVEFLW 580 DPLSTSQTTS 590 LITHCRVILE 600 EHSTCENEVS 610 KSRQDLLKSI 620 VSRMKKAVED 630 DVFIPLYPKS 640 AVENKTSPHS 650 KFQERQFWSG 660 LKLFRNILLW 670 NGLLTDDTLQ 680 ELGLGKLLNR 690 YLIIALLNAT 700 PGPDVVKKCN 710 QVAACLPEKW 720 FENSAMRTSI 730 PQLENFIQFL 740 LQSAHKLSRS 750 EFRDEVEEII 760 LILVKIKALN 770 QAESFIGEHH 780 LDHLKSLIKE D

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005730 nucleolus
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0071008 U2-type post-mRNA release spliceosomal complex
Molecular Function GO:0003677 DNA binding
Biological Process GO:0000398 mRNA splicing, via spliceosome
Biological Process GO:0000245 spliceosomal complex assembly

Reference

[1] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.