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Overview

Uniprot IDP16402
Protein NameHistone H1.3
Gene NameH1-3
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
107 TGASGSFKLNKKAAS
141 GAAKKPKKVAGAATP
149 VAGAATPKKSIKKTP
161 KTPKKVKKPATAAGT
35 GATAGKRKASGPPVS
47 PVSELITKAVAASKE
53 TKAVAASKERSGVSL
76 AAGYDVEKNNSRIKL
86 SRIKLGLKSLVSKGT
91 GLKSLVSKGTLVQTK
98 KGTLVQTKGTGASGS

Function

Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber (PubMed:37922872). Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers and promote formation of the H3K27me3 mark by the PRC2/EED-EZH2 complex (PubMed:40516528). Together with histone H1-3, histone H1-3 acts as a regulator of splicing, most specifically exon skipping and intron retention events: histone H1-3 has a high affinity for introns and regulates splicing by affecting RNA polymerase II (RNAPII) elongation (PubMed:37922872). Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity)

Protein Sequence

10 MSETAPLAPT 20 IPAPAEKTPV 30 KKKAKKAGAT 40 AGKRKASGPP 50 VSELITKAVA 60 ASKERSGVSL 70 AALKKALAAA 80 GYDVEKNNSR 90 IKLGLKSLVS 100 KGTLVQTKGT 110 GASGSFKLNK 120 KAASGEGKPK 130 AKKAGAAKPR 140 KPAGAAKKPK 150 KVAGAATPKK 160 SIKKTPKKVK 170 KPATAAGTKK 180 VAKSAKKVKT 190 PQPKKAAKSP 200 AKAKAPKPKA 210 AKPKSGKPKV 220 TKAKKAAPKK K

Gene Ontology

Classification GO ID Description
Cellular Component GO:0000785 chromatin
Cellular Component GO:0000791 euchromatin
Cellular Component GO:0000792 heterochromatin
Cellular Component GO:0000786 nucleosome
Cellular Component GO:0005634 nucleus
Molecular Function GO:0031490 chromatin DNA binding
Molecular Function GO:0003690 double-stranded DNA binding
Molecular Function GO:0031492 nucleosomal DNA binding
Molecular Function GO:0003723 RNA binding
Molecular Function GO:0030527 structural constituent of chromatin
Biological Process GO:0030261 chromosome condensation
Biological Process GO:0045910 negative regulation of DNA recombination
Biological Process GO:0006334 nucleosome assembly
Biological Process GO:0048024 regulation of mRNA splicing, via spliceosome

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.