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Overview

Uniprot IDP16413
Protein NameGlutathione S-transferase B
Gene NameGSTM1
OrganismCavia porcellus

Kla Sites from experimental identification

Position Flanking peptide
123 SPDFEQKKAEFLEGI
135 EGIPDKMKLFSQFLG
198 EKISSYMKSSRFLPK
205 KSSRFLPKPLFSKFA
49 RSQWLNEKFKLGLDF
82 ILRYIARKHNLCGVT

Function

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2). Participates in the formation of novel hepoxilin regioisomers

Protein Sequence

10 PMTLGYWNIR 20 GLTHPIRLIL 30 EYTNSGYEEK 40 RYNMGDAPDY 50 DRSQWLNEKF 60 KLGLDFPNLP 70 YLIDGTHKLT 80 QSNAILRYIA 90 RKHNLCGVTE 100 EETIRMDILE 110 NQVMDIRMQL 120 IMLCYSPDFE 130 QKKAEFLEGI 140 PDKMKLFSQF 150 LGKLPWFAGN 160 KLTYVDFLAY 170 DVLDQYRMLE 180 PKCLEAFPNL 190 KDFISRFEGL 200 EKISSYMKSS 210 RFLPKPLFSK FAFWNNK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Molecular Function GO:0004364 glutathione transferase activity
Biological Process GO:1901687 glutathione derivative biosynthetic process
Biological Process GO:0006749 glutathione metabolic process
Biological Process GO:0051122 hepoxilin biosynthetic process
Biological Process GO:0006693 prostaglandin metabolic process

Reference

[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.