Search Results
Overview
| Uniprot ID | P16422 |
|---|---|
| Protein Name | Epithelial cell adhesion molecule |
| Gene Name | EPCAM |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 106 | CDESGLFKAKQCNGT |
| 160 | REKPYDSKSLRTALQ |
| 229 | GESLFHSKKMDLTVN |
Function
May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E
Protein Sequence
10
MAPPQVLAFG
20
LLLAAATATF
30
AAAQEECVCE
40
NYKLAVNCFV
50
NNNRQCQCTS
60
VGAQNTVICS
70
KLAAKCLVMK
80
AEMNGSKLGR
90
RAKPEGALQN
100
NDGLYDPDCD
110
ESGLFKAKQC
120
NGTSMCWCVN
130
TAGVRRTDKD
140
TEITCSERVR
150
TYWIIIELKH
160
KAREKPYDSK
170
SLRTALQKEI
180
TTRYQLDPKF
190
ITSILYENNV
200
ITIDLVQNSS
210
QKTQNDVDIA
220
DVAYYFEKDV
230
KGESLFHSKK
240
MDLTVNGEQL
250
DLDPGQTLIY
260
YVDEKAPEFS
270
MQGLKAGVIA
280
VIVVVVIAVV
290
AGIVVLVISR
300
KKRMAKYEKA
310
EIKEMGEMHR
ELNA
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0016324 | apical plasma membrane |
| Cellular Component | GO:0016323 | basolateral plasma membrane |
| Cellular Component | GO:0005923 | bicellular tight junction |
| Cellular Component | GO:0009986 | cell surface |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0016328 | lateral plasma membrane |
| Cellular Component | GO:0005886 | plasma membrane |
| Molecular Function | GO:0098641 | cadherin binding involved in cell-cell adhesion |
| Molecular Function | GO:0044877 | protein-containing complex binding |
| Biological Process | GO:2000048 | negative regulation of cell-cell adhesion mediated by cadherin |
| Biological Process | GO:0008284 | positive regulation of cell population proliferation |
| Biological Process | GO:2000648 | positive regulation of stem cell proliferation |
| Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| Biological Process | GO:0023019 | signal transduction involved in regulation of gene expression |
| Biological Process | GO:0048863 | stem cell differentiation |
| Biological Process | GO:0001657 | ureteric bud development |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.