Search Results
Overview
| Uniprot ID | P16435 |
|---|---|
| Protein Name | NADPH--cytochrome P450 reductase |
| Gene Name | POR |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 186 | EHFNAMGKYVDKRLE |
| 267 | MGEMGRLKSYENQKP |
| 555 | AWLRQQGKEVGETLL |
| 602 | FSREQSHKVYVQHLL |
Function
This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5
Protein Sequence
10
MGDSHVDTSS
20
TVSEAVAEEV
30
SLFSMTDMIL
40
FSLIVGLLTY
50
WFLFRKKKEE
60
VPEFTKIQTL
70
TSSVRESSFV
80
EKMKKTGRNI
90
IVFYGSQTGT
100
AEEFANRLSK
110
DAHRYGMRGM
120
SADPEEYDLA
130
DLSSLPEIDN
140
ALVVFCMATY
150
GEGDPTDNAQ
160
DFYDWLQETD
170
VDLSGVKFAV
180
FGLGNKTYEH
190
FNAMGKYVDK
200
RLEQLGAQRI
210
FELGLGDDDG
220
NLEEDFITWR
230
EQFWPAVCEH
240
FGVEATGEES
250
SIRQYELVVH
260
TDIDAAKVYM
270
GEMGRLKSYE
280
NQKPPFDAKN
290
PFLAAVTTNR
300
KLNQGTERHL
310
MHLELDISDS
320
KIRYESGDHV
330
AVYPANDSAL
340
VNQLGKILGA
350
DLDVVMSLNN
360
LDEESNKKHP
370
FPCPTSYRTA
380
LTYYLDITNP
390
PRTNVLYELA
400
QYASEPSEQE
410
LLRKMASSSG
420
EGKELYLSWV
430
VEARRHILAI
440
LQDCPSLRPP
450
IDHLCELLPR
460
LQARYYSIAS
470
SSKVHPNSVH
480
ICAVVVEYET
490
KAGRINKGVA
500
TNWLRAKEPA
510
GENGGRALVP
520
MFVRKSQFRL
530
PFKATTPVIM
540
VGPGTGVAPF
550
IGFIQERAWL
560
RQQGKEVGET
570
LLYYGCRRSD
580
EDYLYREELA
590
QFHRDGALTQ
600
LNVAFSREQS
610
HKVYVQHLLK
620
QDREHLWKLI
630
EGGAHIYVCG
640
DARNMARDVQ
650
NTFYDIVAEL
660
GAMEHAQAVD
670
YIKKLMTKGR
YSLDVWS
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Biological Process | GO:0006809 | nitric oxide biosynthetic process |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005789 | endoplasmic reticulum membrane |
| Cellular Component | GO:0043231 | intracellular membrane-bounded organelle |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0005654 | nucleoplasm |
| Molecular Function | GO:0004128 | cytochrome-b5 reductase activity, acting on NAD(P)H |
| Molecular Function | GO:0009055 | electron transfer activity |
| Molecular Function | GO:0008047 | enzyme activator activity |
| Molecular Function | GO:0019899 | enzyme binding |
| Molecular Function | GO:0050660 | flavin adenine dinucleotide binding |
| Molecular Function | GO:0010181 | FMN binding |
| Molecular Function | GO:0016787 | hydrolase activity |
| Molecular Function | GO:0047726 | iron-cytochrome-c reductase activity |
| Molecular Function | GO:0050661 | NADP binding |
| Molecular Function | GO:0003958 | NADPH-hemoprotein reductase activity |
| Molecular Function | GO:0008941 | nitric oxide dioxygenase NAD(P)H activity |
| Biological Process | GO:0009437 | carnitine metabolic process |
| Biological Process | GO:0071372 | cellular response to follicle-stimulating hormone stimulus |
| Biological Process | GO:0071375 | cellular response to peptide hormone stimulus |
| Biological Process | GO:0070988 | demethylation |
| Biological Process | GO:0022900 | electron transport chain |
| Biological Process | GO:0019395 | fatty acid oxidation |
| Biological Process | GO:0043066 | negative regulation of apoptotic process |
| Biological Process | GO:0043602 | nitrate catabolic process |
| Biological Process | GO:0046210 | nitric oxide catabolic process |
| Biological Process | GO:0090346 | organofluorine metabolic process |
| Biological Process | GO:0140647 | P450-containing electron transport chain |
| Biological Process | GO:0032332 | positive regulation of chondrocyte differentiation |
| Biological Process | GO:0061913 | positive regulation of growth plate cartilage chondrocyte proliferation |
| Biological Process | GO:0045880 | positive regulation of smoothened signaling pathway |
| Biological Process | GO:0090031 | positive regulation of steroid hormone biosynthetic process |
| Biological Process | GO:0071548 | response to dexamethasone |
| Biological Process | GO:0009725 | response to hormone |
| Biological Process | GO:0007584 | response to nutrient |
| Biological Process | GO:0009410 | response to xenobiotic stimulus |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.