Search Results
Overview
| Uniprot ID | P16446 |
|---|---|
| Protein Name | Phosphatidylinositol transfer protein alpha isoform |
| Gene Name | Pitpna |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 5 | ***MVLLKEYRVILP |
Function
Catalyzes the transfer of phosphatidylinositol (PI) and phosphatidylcholine (PC) between membranes (PubMed:18636990, PubMed:7568025). Shows a preference for PI and PC containing shorter saturated or monosaturated acyl chains at the sn-1 and sn-2 positions (By similarity). Preference order for PC is C16:1 > C16:0 > C18:1 > C18:0 > C20:4 and for PI is C16:1 > C16:0 > C18:1 > C18:0 > C20:4 > C20:3 (By similarity)
Protein Sequence
10
MVLLKEYRVI
20
LPVSVDEYQV
30
GQLYSVAEAS
40
KNETGGGEGV
50
EVLVNEPYEK
60
DDGEKGQYTH
70
KIYHLQSKVP
80
TFVRMLAPEG
90
ALNIHEKAWN
100
AYPYCRTVIT
110
NEYMKEDFLI
120
KIETWHKPDL
130
GTQENVHKLE
140
PEAWKHVEAI
150
YIDIADRSQV
160
LSKDYKAEED
170
PAKFKSIKTG
180
RGPLGPNWKQ
190
ELVNQKDCPY
200
MCAYKLVTVK
210
FKWWGLQNKV
220
ENFIHKQEKR
230
LFTNFHRQLF
240
CWLDKWVDLT
250
MDDIRRMEEE
260
TKRQLDEMRQ
270
KDPVKGMTAD
D
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0000062 | fatty-acyl-CoA binding |
| Molecular Function | GO:0008289 | lipid binding |
| Molecular Function | GO:0031210 | phosphatidylcholine binding |
| Molecular Function | GO:0120019 | phosphatidylcholine transfer activity |
| Molecular Function | GO:0008525 | phosphatidylcholine transporter activity |
| Molecular Function | GO:0035091 | phosphatidylinositol binding |
| Molecular Function | GO:0008526 | phosphatidylinositol transfer activity |
| Molecular Function | GO:0005543 | phospholipid binding |
| Molecular Function | GO:0070540 | stearic acid binding |
| Biological Process | GO:0007409 | axonogenesis |
| Biological Process | GO:0015914 | phospholipid transport |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.