Search Results
Overview
| Uniprot ID | P16455 |
|---|---|
| Protein Name | Methylated-DNA--protein-cysteine methyltransferase |
| Gene Name | MGMT |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 178 | HEGHRLGKPGLGGSS |
Function
Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated
Protein Sequence
10
MDKDCEMKRT
20
TLDSPLGKLE
30
LSGCEQGLHE
40
IKLLGKGTSA
50
ADAVEVPAPA
60
AVLGGPEPLM
70
QCTAWLNAYF
80
HQPEAIEEFP
90
VPALHHPVFQ
100
QESFTRQVLW
110
KLLKVVKFGE
120
VISYQQLAAL
130
AGNPKAARAV
140
GGAMRGNPVP
150
ILIPCHRVVC
160
SSGAVGNYSG
170
GLAVKEWLLA
180
HEGHRLGKPG
190
LGGSSGLAGA
200
WLKGAGATSG
SPPAGRN
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0003677 | DNA binding |
| Molecular Function | GO:0009008 | DNA-methyltransferase activity |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0003908 | methylated-DNA-[protein]-cysteine S-methyltransferase activity |
| Molecular Function | GO:0008168 | methyltransferase activity |
| Biological Process | GO:0006281 | DNA repair |
| Biological Process | GO:0032259 | methylation |
| Biological Process | GO:0043066 | negative regulation of apoptotic process |
| Biological Process | GO:2000781 | positive regulation of double-strand break repair |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.