Search Results
Overview
| Uniprot ID | P16520 |
|---|---|
| Protein Name | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 |
| Gene Name | GNB3 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 89 | WDSYTTNKVHAIPLR |
Function
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction
Protein Sequence
10
MGEMEQLRQE
20
AEQLKKQIAD
30
ARKACADVTL
40
AELVSGLEVV
50
GRVQMRTRRT
60
LRGHLAKIYA
70
MHWATDSKLL
80
VSASQDGKLI
90
VWDSYTTNKV
100
HAIPLRSSWV
110
MTCAYAPSGN
120
FVACGGLDNM
130
CSIYNLKSRE
140
GNVKVSRELS
150
AHTGYLSCCR
160
FLDDNNIVTS
170
SGDTTCALWD
180
IETGQQKTVF
190
VGHTGDCMSL
200
AVSPDFNLFI
210
SGACDASAKL
220
WDVREGTCRQ
230
TFTGHESDIN
240
AICFFPNGEA
250
ICTGSDDASC
260
RLFDLRADQE
270
LICFSHESII
280
CGITSVAFSL
290
SGRLLFAGYD
300
DFNCNVWDSM
310
KSERVGILSG
320
HDNRVSCLGV
330
TADGMAVATG
340
SWDSFLKIWN
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0044297 | cell body |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0030425 | dendrite |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0005834 | heterotrimeric G-protein complex |
| Cellular Component | GO:0005886 | plasma membrane |
| Molecular Function | GO:0003924 | GTPase activity |
| Molecular Function | GO:0051020 | GTPase binding |
| Molecular Function | GO:0030159 | signaling receptor complex adaptor activity |
| Molecular Function | GO:0030507 | spectrin binding |
| Biological Process | GO:0006884 | cell volume homeostasis |
| Biological Process | GO:0007186 | G protein-coupled receptor signaling pathway |
| Biological Process | GO:0008217 | regulation of blood pressure |
| Biological Process | GO:0090181 | regulation of cholesterol metabolic process |
| Biological Process | GO:0045598 | regulation of fat cell differentiation |
| Biological Process | GO:0010468 | regulation of gene expression |
| Biological Process | GO:0010906 | regulation of glucose metabolic process |
| Biological Process | GO:0032350 | regulation of hormone metabolic process |
| Biological Process | GO:1903725 | regulation of phospholipid metabolic process |
| Biological Process | GO:0090207 | regulation of triglyceride metabolic process |
Reference
[1] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.