Search Results
Overview
| Uniprot ID | P16615 |
|---|---|
| Protein Name | Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 |
| Gene Name | ATP2A2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 169 | DIRLTSIKSTTLRVD |
| 492 | LEFSRDRKSMSVYCT |
| 502 | SVYCTPNKPSRTSMS |
| 541 | VPMTSGVKQKIMSVI |
| 712 | NDAPALKKAEIGIAM |
| 995 | RNYLEPGKECVQPAT |
Function
This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen (PubMed:12542527, PubMed:16402920). Involved in autophagy in response to starvation. Upon interaction with VMP1 and activation, controls ER-isolation membrane contacts for autophagosome formation (PubMed:28890335). Also modulates ER contacts with lipid droplets, mitochondria and endosomes (PubMed:28890335). In coordination with FLVCR2 mediates heme-stimulated switching from mitochondrial ATP synthesis to thermogenesis (By similarity)
Protein Sequence
10
MENAHTKTVE
20
EVLGHFGVNE
30
STGLSLEQVK
40
KLKERWGSNE
50
LPAEEGKTLL
60
ELVIEQFEDL
70
LVRILLLAAC
80
ISFVLAWFEE
90
GEETITAFVE
100
PFVILLILVA
110
NAIVGVWQER
120
NAENAIEALK
130
EYEPEMGKVY
140
RQDRKSVQRI
150
KAKDIVPGDI
160
VEIAVGDKVP
170
ADIRLTSIKS
180
TTLRVDQSIL
190
TGESVSVIKH
200
TDPVPDPRAV
210
NQDKKNMLFS
220
GTNIAAGKAM
230
GVVVATGVNT
240
EIGKIRDEMV
250
ATEQERTPLQ
260
QKLDEFGEQL
270
SKVISLICIA
280
VWIINIGHFN
290
DPVHGGSWIR
300
GAIYYFKIAV
310
ALAVAAIPEG
320
LPAVITTCLA
330
LGTRRMAKKN
340
AIVRSLPSVE
350
TLGCTSVICS
360
DKTGTLTTNQ
370
MSVCRMFILD
380
RVEGDTCSLN
390
EFTITGSTYA
400
PIGEVHKDDK
410
PVNCHQYDGL
420
VELATICALC
430
NDSALDYNEA
440
KGVYEKVGEA
450
TETALTCLVE
460
KMNVFDTELK
470
GLSKIERANA
480
CNSVIKQLMK
490
KEFTLEFSRD
500
RKSMSVYCTP
510
NKPSRTSMSK
520
MFVKGAPEGV
530
IDRCTHIRVG
540
STKVPMTSGV
550
KQKIMSVIRE
560
WGSGSDTLRC
570
LALATHDNPL
580
RREEMHLEDS
590
ANFIKYETNL
600
TFVGCVGMLD
610
PPRIEVASSV
620
KLCRQAGIRV
630
IMITGDNKGT
640
AVAICRRIGI
650
FGQDEDVTSK
660
AFTGREFDEL
670
NPSAQRDACL
680
NARCFARVEP
690
SHKSKIVEFL
700
QSFDEITAMT
710
GDGVNDAPAL
720
KKAEIGIAMG
730
SGTAVAKTAS
740
EMVLADDNFS
750
TIVAAVEEGR
760
AIYNNMKQFI
770
RYLISSNVGE
780
VVCIFLTAAL
790
GFPEALIPVQ
800
LLWVNLVTDG
810
LPATALGFNP
820
PDLDIMNKPP
830
RNPKEPLISG
840
WLFFRYLAIG
850
CYVGAATVGA
860
AAWWFIAADG
870
GPRVSFYQLS
880
HFLQCKEDNP
890
DFEGVDCAIF
900
ESPYPMTMAL
910
SVLVTIEMCN
920
ALNSLSENQS
930
LLRMPPWENI
940
WLVGSICLSM
950
SLHFLILYVE
960
PLPLIFQITP
970
LNVTQWLMVL
980
KISLPVILMD
990
ETLKFVARNY
1000
LEPGKECVQP
1010
ATKSCSFSAC
1020
TDGISWPFVL
1030
LIMPLVIWVY
1040
STDTNFSDMF
WS
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0016529 | sarcoplasmic reticulum |
| Cellular Component | GO:0033017 | sarcoplasmic reticulum membrane |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0016887 | ATP hydrolysis activity |
| Molecular Function | GO:0005246 | calcium channel regulator activity |
| Molecular Function | GO:0005509 | calcium ion binding |
| Molecular Function | GO:0019899 | enzyme binding |
| Molecular Function | GO:0106222 | lncRNA binding |
| Molecular Function | GO:0005388 | P-type calcium transporter activity |
| Molecular Function | GO:0086039 | P-type calcium transporter activity involved in regulation of cardiac muscle cell membrane potential |
| Molecular Function | GO:0044548 | S100 protein binding |
| Molecular Function | GO:0044325 | transmembrane transporter binding |
| Biological Process | GO:0000045 | autophagosome assembly |
| Biological Process | GO:0016240 | autophagosome membrane docking |
| Biological Process | GO:1990036 | calcium ion import into sarcoplasmic reticulum |
| Biological Process | GO:0070588 | calcium ion transmembrane transport |
| Biological Process | GO:1903515 | calcium ion transport from cytosol to endoplasmic reticulum |
| Biological Process | GO:0007155 | cell adhesion |
| Biological Process | GO:0032469 | endoplasmic reticulum calcium ion homeostasis |
| Biological Process | GO:0008544 | epidermis development |
| Biological Process | GO:0006874 | intracellular calcium ion homeostasis |
| Biological Process | GO:1990456 | mitochondrion-endoplasmic reticulum membrane tethering |
| Biological Process | GO:0034220 | monoatomic ion transmembrane transport |
| Biological Process | GO:0003012 | muscle system process |
| Biological Process | GO:0140056 | organelle localization by membrane tethering |
| Biological Process | GO:0032470 | positive regulation of endoplasmic reticulum calcium ion concentration |
| Biological Process | GO:0010460 | positive regulation of heart rate |
| Biological Process | GO:1903779 | regulation of cardiac conduction |
| Biological Process | GO:0098909 | regulation of cardiac muscle cell action potential involved in regulation of contraction |
| Biological Process | GO:0086036 | regulation of cardiac muscle cell membrane potential |
| Biological Process | GO:0010882 | regulation of cardiac muscle contraction by calcium ion signaling |
| Biological Process | GO:0055119 | relaxation of cardiac muscle |
| Biological Process | GO:0034976 | response to endoplasmic reticulum stress |
| Biological Process | GO:0070296 | sarcoplasmic reticulum calcium ion transport |
| Cellular Component | GO:0090534 | calcium ion-transporting ATPase complex |
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Cellular Component | GO:0005789 | endoplasmic reticulum membrane |
| Cellular Component | GO:0014801 | longitudinal sarcoplasmic reticulum |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0031095 | platelet dense tubular network membrane |
| Cellular Component | GO:0097470 | ribbon synapse |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.